Triesence

Macular Edema, Stomatitis, Denture, Ophthalmia, Sympathetic + 113 more

Treatment

16 FDA approvals

20 Active Studies for Triesence

Treatment for

Macular Edema

What is Triesence

Triamcinolone

The Generic name of this drug

Treatment Summary

Triamcinolone is a type of steroid used to reduce inflammation and treat a wide range of conditions, including allergic rhinitis and multiple sclerosis. It is available in several forms, such as triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate. Triamcinolone was approved by the FDA in 1957 and in 2021, a suspension of triamcinolone acetonide was also approved for suprachoroidal injection to treat macular edema associated with uveitis.

Aristocort

is the brand name

image of different drug pills on a surface

Triesence Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aristocort

Triamcinolone

1961

532

Approved as Treatment by the FDA

Triamcinolone, also called Aristocort, is approved by the FDA for 16 uses which include Lichen Planus and Ganglia .

Lichen Planus

Helps manage Lichen Planus (LP)

Ganglia

Helps manage cystic tumour of the ganglia

Granuloma Annulare

Helps manage granuloma annulare lesions

Psoriasis

Helps manage Psoriatic plaque

Neurodermatitis

Helps manage Lichen simplex chronicus

Lupus Erythematosus, Discoid

Helps manage Discoid Lupus Erythematosus (DLE)

cystic tumour of the ganglia

Helps manage cystic tumour of the ganglia

granuloma annulare lesions

Helps manage granuloma annulare lesions

Lichen Planus (LP)

Helps manage Lichen Planus (LP)

Psoriatic plaque

Helps manage Psoriatic plaque

Discoid Lupus Erythematosus (DLE)

Helps manage Discoid Lupus Erythematosus (DLE)

Necrobiosis Lipoidica

Helps manage Necrobiosis lipoidica diabeticorum

Alopecia Areata

Helps manage Alopecia Areata (AA)

Alopecia Areata (AA)

Helps manage Alopecia Areata (AA)

Lichen simplex chronicus

Helps manage Lichen simplex chronicus

Keloids Scars

Helps manage Keloids Scars

Effectiveness

How Triesence Affects Patients

Triamcinolone is a type of steroid that helps reduce inflammation in different parts of the body. It should not be injected into the spine.

How Triesence works in the body

Triamcinolone stops inflammation by blocking cell molecules from breaking down. This prevents leukocytes from forming arachidonic acid, which stops the production of chemicals that cause inflammation, such as prostaglandins and leukotrienes. Triamcinolone also reverses vascular dilation and reduces permeability, which limits the movement of macrophages and leukocytes. Lastly, it prevents nuclear factor kappa-B from creating pro-inflammatory signals like interleukin-6, interleukin-8, and monocyte chemoattractant protein-1.

When to interrupt dosage

The advisable dosage of Triesence is reliant upon the determined condition, for instance Mycosis Fungoides (MF), Mycoses and Alopecia Areata (AA). The measure of dosage fluctuates, per the administration approach (e.g. Ointment or Injection, suspension - Intralesional; Parenteral) presented in the accompanying table.

Condition

Dosage

Administration

Stomatitis, Denture

, 40.0 mg/mL, 10.0 mg/mL, 0.055 mg, 0.001 mg/mg, 0.25 mg/mL, 1.0 mg/mL, 0.0005 mg/mg, 0.00025 mg/mg, 0.005 mg/mg, 5.0 mg/mL, 20.0 mg/mL, 0.000147 mg/mg, 0.5 mg/mL, 40.0 mg, 1.0 mg, 0.000025 mg/mg, 0.1 %, 0.025 %, 5.0 mg, 0.25 mg, 2.0 mg, 4.0 mg, 0.5 %, 15.0 mg/mL, 6.5 mg, 80.0 mg/mL, 0.075 mg, 200.0 mg/mL, 32.0 mg, 0.055 mg/dose, 0.5 mg, 0.2 mg/pump actuation, 0.1 mg/dose, 25.0 mg/mL, 0.055 mg/pump actuation, 2.0 mg/mL, 0.4 mg/mL

Injection, suspension, Intra-articular; Intramuscular, Injection, suspension - Intra-articular; Intramuscular, , Injection, suspension - Intra-articular; Intralesional, Intra-articular; Intralesional, Spray, metered, Nasal, Spray, metered - Nasal, Topical, Ointment - Topical, Lotion, Lotion - Topical, Ointment, Intra-articular; Intrabursal; Intradermal; Intralesional, Injection, suspension - Intra-articular; Intrabursal; Intradermal; Intralesional, Aerosol, spray, Aerosol, spray - Topical, Cream - Topical, Cream, Paste - Topical, Paste, Intramuscular, Injection, suspension - Intramuscular, Intra-articular; Intrabursal; Intradermal; Intrasynovial, Suspension - Intra-articular; Intramuscular, Suspension - Intra-articular; Intrabursal; Intradermal; Intrasynovial, Suspension - Intra-articular; Intrabursal; Intramuscular, Intra-articular; Intrabursal; Intramuscular, Oral, Tablet, Tablet - Oral, Injection, suspension - Intralesional; Parenteral, Intra-articular; Parenteral, Injection, suspension - Intra-articular; Parenteral, Intralesional; Parenteral, Kit, Paste - Dental, Dental, Suspension, Intralesional, Suspension - Intralesional, Aerosol, metered - Nasal, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Respiratory (inhalation), Intra-articular, Suspension - Intra-articular, Intra-articular; Intramuscular; Intrasynovial, Liquid - Intra-articular; Intramuscular; Intrasynovial, Intra-articular; Intradermal; Intramuscular, Syrup - Oral, Syrup, Suspension - Intramuscular, Liquid, Liquid - Intra-articular; Intradermal; Intramuscular, Spray, suspension - Nasal, Injection, solution, Injection, solution - Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Ophthalmic, Injection, suspension - Ophthalmic, Suspension - Intravitreal, Intravitreal, Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Kit - Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Intra-articular; Intrasynovial; Periarticular, Suspension - Intra-articular; Intrasynovial; Periarticular, Suspension - Ophthalmic, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Intra-articular; Intradermal; Intralesional; Intramuscular, Suspension - Intra-articular; Intradermal; Intralesional; Intramuscular, Spray - Topical, Spray, Kit - Intra-articular; Intramuscular, Subcutaneous, Implant - Subcutaneous, Implant, Injection, suspension - Intra-articular; Intramuscular; Intravitreal, Intra-articular; Intramuscular; Intravitreal, Kit - Epidural; Intra-articular; Intramuscular; Topical, Epidural; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional, Kit - Epidural; Infiltration; Intra-articular; Intralesional, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Paste, dentifrice, Paste, dentifrice - Dental, Infiltration; Soft tissue; Topical, Kit - Infiltration; Soft tissue; Topical, Gel, Emulsion - Topical, Emulsion, Gel - Topical, Intra-articular; Intramuscular; Topical, Kit - Topical, Injection, suspension - Intra-articular, Kit - Intra-articular, Ointment - Buccal, Buccal, Infiltration; Intra-articular; Intramuscular; Topical, Kit - Infiltration; Intra-articular; Intramuscular; Topical

Ophthalmia, Sympathetic

Stomatitis, Aphthous

Macular Edema

Inflammation

Multiple Sclerosis

Berylliosis

Neurodermatitis

Intertrigo

Pericarditis

Necrobiosis Lipoidica

Adrenal Insufficiency

cutaneous candidiasis

Rheumatic Heart Disease

Thrombocytopenia

Eosinophilic Pneumonia

Thyroiditis

Anemia, Hemolytic, Autoimmune

Wound Infection

Lupus Erythematosus, Discoid

Warnings

Triesence has four counterindications and should not be combined with any of the afflictions enumerated in the table below.

Triesence Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Triamcinolone may interact with Pulse Frequency

Mycoses

Do Not Combine

active periocular infections

Do Not Combine

Eye Infections

Do Not Combine

There are 20 known major drug interactions with Triesence.

Common Triesence Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Triamcinolone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with Abetimus.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Triamcinolone.

Triesence Toxicity & Overdose Risk

The lowest toxic dose of triamcinolone acetonide in rats is 13,100 µg/kg and 132mg/kg in mice. The toxic dose when administered orally to rats is 1451mg/kg and 2168mg/kg in mice, and 105mg/kg when given intraperitoneally in mice. Overdosing on this drug may produce Cushing's syndrome, which can be treated with supportive care and mifepristone.

image of a doctor in a lab doing drug, clinical research

Triesence Novel Uses: Which Conditions Have a Clinical Trial Featuring Triesence?

1076 active clinical trials are being conducted to assess the potential of Triesence in the treatment of Lupus, Atopic Dermatitis and Brain Metastases.

Condition

Clinical Trials

Trial Phases

Synovitis

1 Actively Recruiting

Phase 4

Lupus

63 Actively Recruiting

Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1

Crohn's Disease

57 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1

Erythema Multiforme

0 Actively Recruiting

Asthma

97 Actively Recruiting

Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3

Vitrectomy therapy

0 Actively Recruiting

Dermatitis, Seborrheic

0 Actively Recruiting

Rheumatoid Arthritis

63 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Macular Edema

4 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Thyroiditis

0 Actively Recruiting

Brain

2 Actively Recruiting

Not Applicable

Stomatitis

0 Actively Recruiting

Dermatitis

0 Actively Recruiting

Tinea

0 Actively Recruiting

Conjunctivitis, Bacterial

0 Actively Recruiting

Tenosynovitis

0 Actively Recruiting

Mycoses

0 Actively Recruiting

Dermatitis, Allergic Contact

0 Actively Recruiting

Cellulitis

0 Actively Recruiting

Lupus Erythematosus

3 Actively Recruiting

Phase 4, Phase 1, Not Applicable

Triesence Reviews: What are patients saying about Triesence?

Patient Review

2/6/2015

Triesence for Surgical Vitrectomy Adjunct to Enhance Visualization

This product, as a corticosteroid, has caused my liver enzyme levels to rise. I'm wondering if this is a possible side effect.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about triesence

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Triesence a corticosteroid?

"TRIESENCE is an anti-inflammatory corticosteroid that comes in injectable form. It contains 40 mg/mL of the active ingredient triamcinolone acetonide."

Answered by AI

What is the difference between kenalog and Triesence?

"The conglomerate will reduce the surface area and decrease the dissolution rate, though Triesence is formulated to have a smaller particle size than Kenalog-40. Triesence and Kenalog-40 have a 100% crystallinity, which should not cause the different vitreous dissolution rates observed."

Answered by AI

What is Triesence used for?

"Triesence is a steroid injection used to treat inflammation of the joints or tendons that is caused by arthritis, bursitis, or epicondylitis (tennis elbow). Triesence is usually given for a short period of time to treat a severe or aggravated episode."

Answered by AI