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BMS-986553 for Autoimmune Diseases

Not yet recruiting at 22 trial locations
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Overseen ByFirst line of the email MUST contain NCT # and Site #.
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Bristol-Myers Squibb
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to evaluate the safety and tolerability of BMS-986553, CD19 in vivo Chimeric Antigen Receptor (CAR) T cells, in participants with refractory autoimmune diseases including systemic lupus erythematosus (SLE), idiopathic inflammatory myopathies (IIM), systemic sclerosis (SSc), rheumatoid arthritis (RA), and Sjögren's disease (SjD).

Who Is on the Research Team?

BS

Bristol-Myers Squibb

Principal Investigator

Bristol-Myers Squibb

Are You a Good Fit for This Trial?

This trial is for people with autoimmune diseases like lupus, rheumatoid arthritis, Sjögren's syndrome, myositis, or systemic sclerosis who have not improved with standard treatments. Participants must meet specific health requirements and cannot join if they have certain other medical conditions.

Inclusion Criteria

I have a confirmed diagnosis of idiopathic inflammatory myopathy (IIM).
I have been diagnosed with systemic sclerosis (SSc) by my doctor.
I have been diagnosed with primary Sjögren's disease by 2016 criteria.
See 2 more

Exclusion Criteria

Other protocol-defined Inclusion/Exclusion criteria apply
I do not have any other immune system disorders.

What Are the Treatments Tested in This Trial?

Interventions

  • BMS-986553

Trial Overview

The study is testing a new treatment called BMS-986553 (a type of CAR T cell therapy) to see if it is safe and tolerable in people whose autoimmune disease has not responded to usual therapies.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: BMS-986553Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Bristol-Myers Squibb

Lead Sponsor

Trials
2,731
Recruited
4,127,000+
Headquarters
New York City, USA
Known For
Oncology & Cardiovascular
Top Products
Eliquis, Opdivo, Revlimid, Orencia
Christopher Boerner profile image

Christopher Boerner

Bristol-Myers Squibb

Chief Executive Officer since 2023

PhD in Business Administration from the Haas School of Business, University of California, Berkeley; BA in Economics and History from Washington University in St. Louis

Deepak L. Bhatt profile image

Deepak L. Bhatt

Bristol-Myers Squibb

Chief Medical Officer since 2024

MD from Yale University; MSc in Clinical Epidemiology from the University of Pennsylvania

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