Sernivo

Iritis, Nephrotic Syndrome, Iridocyclitis + 90 more

Treatment

14 FDA approvals

20 Active Studies for Sernivo

Treatment for

Iritis

What is Sernivo

Betamethasone

The Generic name of this drug

Treatment Summary

Betamethasone is a long-acting steroid medication used to reduce inflammation and suppress the immune system. It is applied topically to treat skin conditions such as eczema and can also be used systemically to treat autoimmune diseases. Betamethasone has strong anti-inflammatory properties, although it has minimal effects on the body's salt levels.

Celestone Soluspan

is the brand name

Sernivo Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Celestone Soluspan

Betamethasone

1965

264

Approved as Treatment by the FDA

Betamethasone, otherwise known as Celestone Soluspan, is approved by the FDA for 14 uses like Lupus Erythematosus, Discoid and Lichen Planus .

Lupus Erythematosus, Discoid

Helps manage Discoid Lupus Erythematosus (DLE)

Lichen Planus

Helps manage Lichen Planus (LP)

Psoriasis

Helps manage Psoriatic plaque

Granuloma Annulare

Helps manage granuloma annulare lesions

Keloids Scars

Helps manage Keloids Scars

Lichen simplex chronicus

Helps manage Lichen simplex chronicus

granuloma annulare lesions

Helps manage granuloma annulare lesions

Lichen Planus (LP)

Helps manage Lichen Planus (LP)

Alopecia Areata (AA)

Helps manage Alopecia Areata (AA)

Psoriatic plaque

Helps manage Psoriatic plaque

Discoid Lupus Erythematosus (DLE)

Helps manage Discoid Lupus Erythematosus (DLE)

Neurodermatitis

Helps manage Lichen simplex chronicus

Alopecia Areata

Helps manage Alopecia Areata (AA)

Necrobiosis Lipoidica

Helps manage Necrobiosis lipoidica diabeticorum

Effectiveness

How Sernivo Affects Patients

Corticosteroids are drugs that reduce inflammation and can be used to treat a range of conditions. They work by blocking certain signals in the body that cause inflammation, while promoting other signals that reduce it. Corticosteroids are usually given in doses much higher than the body naturally produces. However, long-term use of them can lead to the body becoming less able to fight off infections and cause other issues with the hormone system.

How Sernivo works in the body

Glucocorticoids reduce inflammation by blocking certain molecules from being produced and by increasing the production of anti-inflammatory molecules. Betamethasone works in two ways - it can quickly affect cells and molecules through existing receptors, or slowly affect gene expression. In both cases, it decreases inflammation by preventing the creation of molecules that cause inflammation and increasing the production of molecules that reduce inflammation.

When to interrupt dosage

The measure of Sernivo is contingent upon the indicated condition, including Ankylosing Spondylitis, Adrenal cortical hypofunctions and Post Surgical Ocular Inflammation. The amount of dosage likewise shifts with the technique of delivery (e.g. Topical or Solution - Oral) specified in the table below.

Condition

Dosage

Administration

exfoliative erythroderma

, 0.5 mg/mL, 0.001 mg/mg, 1.0 mg/mL, 0.0005 mg/mg, 0.000643 mg/mg, 0.00064 mg/mg, 0.64 mg, 0.00005 mg/mg, 0.0012 mg/mg, 3.0 mg/mL, 0.64 mg/mL, 0.005 mg/mg, 12.0 mg/mL, 0.05 %, 0.1 %, 0.12 %, 0.5 mg, 0.1 mg, 1.0 mg, 0.025 %, 0.1 mg/mL, 0.6 mg, 6.0 mg, 3.0 mg, 6.0 mg/mL, 7.0 mg/mL, 0.6 mg/mL, 0.643 mg/mL, 0.00061 mg/mg, 0.05 mg/mg, 0.064 mg/mg, 0.05 mg/mL, 0.00122 mg/mg

, Topical, Lotion, Lotion - Topical, Ointment - Topical, Ointment, Cream, Cream - Topical, Spray, metered - Topical, Aerosol, foam, Aerosol, foam - Topical, Ointment, augmented, Lotion, augmented - Topical, Ointment, augmented - Topical, Lotion, augmented, Gel - Topical, Gel, Suspension, Suspension - Topical, Cream, augmented, Cream, augmented - Topical, Epidural; Intramuscular; Intraspinal; Intrathecal, Injection, solution, Intramuscular, Injection, solution - Epidural; Intramuscular; Intraspinal; Intrathecal, Injection, suspension - Epidural; Intramuscular; Intraspinal; Intrathecal, Tablet, Tablet - Topical, Enema, Enema - Rectal, Oral, Tablet - Oral, Tablet, effervescent, Auricular (otic); Ophthalmic, Liquid, Liquid - Auricular (otic); Ophthalmic, Liquid - Topical, Solution / drops, Solution / drops - Auricular (otic); Ophthalmic, Tablet, extended release - Oral, Ointment - Ophthalmic, Tablet, extended release, Spray, Spray - Topical, Intra-articular; Intrabursal; Intradermal; Intramuscular, Kit, Cutaneous, Lotion - Cutaneous, Intra-articular; Intralesional; Intramuscular, Injection, suspension, Intra-articular; Intralesional; Intramuscular; Soft tissue, Suspension - Intra-articular; Intrabursal; Intradermal; Intramuscular, Suspension - Intra-articular; Intralesional; Intramuscular, Spray, metered, Injection, suspension - Intra-articular; Intralesional; Intramuscular, Injection, suspension - Intramuscular, Rectal, Solution, Solution - Auricular (otic); Ophthalmic, Tablet, effervescent - Oral, Ophthalmic, Patch, Patch - Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Intra-articular; Intralesional; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Kit - Topical, Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural, Kit - Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural, Kit - Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical, Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical, Solution - Oral, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Solution - Topical

Adrenal Insufficiency

Arthritis, Juvenile

Psoriasis

Psoriatic Arthritis

Psoriasis Vulgaris

Leukemia

Asthma

Bacterial Infections

Lichen Planus

Lymphoma, Non-Hodgkin

Blepharitis

Giant Cell Arteritis

Congenital adrenal hyperplasia

Brain Tumor

Ankylosing Spondylitis

Eye Infection

Lupus

Verrucous Lichen Planus (LP)

Nephrotic Syndrome

Warnings

Sernivo has one exclusion, so it should not be utilized for the issues indicated in the following table.

Sernivo Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Sernivo.

Common Sernivo Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Betamethasone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with Abetimus.

Sernivo Toxicity & Overdose Risk

Long-term use of glucocorticoids can cause cataracts, glaucoma, high blood pressure, water retention, high cholesterol, stomach ulcers, pancreas inflammation, muscle weakness, mood swings, psychosis, skin thinning, allergies, acne, excess hair growth, weakened immune system, diabetes, low calcium levels, low phosphate levels, acidosis, slowed growth, and decreased production of hormones in the adrenal glands. In the case of overdose, the dose may need to be adjusted or stopped and treatment for the symptoms should begin.

image of a doctor in a lab doing drug, clinical research

Sernivo Novel Uses: Which Conditions Have a Clinical Trial Featuring Sernivo?

At present, 249 active research studies are assessing the usefulness of Sernivo in treating Eye Infections, Alopecia Areata (AA) and Verrucous Lichen Planus (LP).

Condition

Clinical Trials

Trial Phases

Lupus

63 Actively Recruiting

Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1

Conjunctivitis

0 Actively Recruiting

Rheumatoid Arthritis

63 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Brain Tumor

61 Actively Recruiting

Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3

Blepharoconjunctivitis

0 Actively Recruiting

Ulcerative Colitis

26 Actively Recruiting

Phase 3, Phase 2, Phase 1, Not Applicable, Phase 4

Eosinophilic Pneumonia

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Eye Injuries

0 Actively Recruiting

Dermatosis

0 Actively Recruiting

Sarcoidosis

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Arthritis, Gouty

0 Actively Recruiting

Congenital adrenal hyperplasia

7 Actively Recruiting

Phase 3, Phase 1, Phase 2

Verrucous Lichen Planus (LP)

0 Actively Recruiting

Pruritus

0 Actively Recruiting

Inflammatory Reaction of the ear

0 Actively Recruiting

Blepharitis allergic

0 Actively Recruiting

Neurodermatitis

0 Actively Recruiting

Psoriasis Vulgaris

22 Actively Recruiting

Early Phase 1, Phase 3, Phase 4, Phase 2, Not Applicable

Sernivo Reviews: What are patients saying about Sernivo?

3.7

Patient Review

10/25/2016

Sernivo for Plaque Psoriasis

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sernivo

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class steroid is Sernivo?

"Sernivo is a corticosteroid medication used to treat plaque psoriasis and other steroid-responsive dermatoses. It may be used alone or with other medications."

Answered by AI

Is Sernivo a steroid?

"Sernivo is a medium-strength steroid that is typically applied to the affected area twice per day for no more than four weeks."

Answered by AI

What is Sernivo used for?

"Betamethasone is a medication used to treat plaque psoriasis, a type of skin condition. Betamethasone reduces the symptoms of plaque psoriasis, including swelling, itching, and redness. Betamethasone is a strong corticosteroid."

Answered by AI

Is Sernivo discontinued?

"There is no version of Sernivo available in the United States that has the same therapeutic effect. Note: Some online pharmacies may try to sell a generic version of Sernivo that is not approved."

Answered by AI