Search > Parkinson Disease
240 Participants NeededMy employer runs this trial

Acute Exercise for Parkinson's Disease

(EXPLAIN Trial)

CR
Overseen ByClaus Reinsberger, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Brigham and Women's Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are:

* How do fitness level, exercise performance, and physical exhaustion differ between patients with neurological diseases and healthy participants?

* How does acute exercise affect brain function and other physiological biomarkers in participants with neurological diseases?

Participants will take part in a single, one-day study visit and will be asked to:

* Perform a standardized exercise test on a bicycle ergometer

* Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test

Who Is on the Research Team?

CR

Claus Reinsberger, MD, PhD

Principal Investigator

Brigham and Women's Hospital

Are You a Good Fit for This Trial?

This trial is for adults with neurological conditions like Parkinson's, dementia, epilepsy, brain tumors, or mild cognitive impairment, as well as healthy volunteers. Participants must be able to safely exercise and undergo MRI scans.

Inclusion Criteria

I am 18 years old or older.
I have not been diagnosed with any neurological disease.
I have been diagnosed with a neurological disease like epilepsy or dementia.

Exclusion Criteria

Non-english speaking individuals
Exercise contraindications including physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures
I am currently taking medication to control my heart rhythm or rate.
See 1 more

What Are the Treatments Tested in This Trial?

Interventions

  • Acute Exercise

Trial Overview

The study tests how a single session of moderate exercise on a stationary bike affects brain function and body markers in people with neurological disorders compared to healthy individuals. All participants complete the same one-day protocol.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Acute ExerciseExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Brigham and Women's Hospital

Lead Sponsor

Trials
1,694
Recruited
14,790,000+

Unbiased Results

We believe in providing patients with all the options.

Your Data Stays Your Data

We only share your information with the clinical trials you're trying to access.

Verified Trials Only

All of our trials are run by licensed doctors, researchers, and healthcare companies.