Enstilar

Iritis, Nephrotic Syndrome, Iridocyclitis + 90 more

Treatment

14 FDA approvals

20 Active Studies for Enstilar

Treatment for

Iritis

What is Enstilar

Betamethasone

The Generic name of this drug

Treatment Summary

Betamethasone is a steroid medication with anti-inflammatory and immune-suppressing properties. It can be used as a topical cream to treat skin conditions like eczema, or as an injection to treat autoimmune disorders. Betamethasone is primarily a glucocorticoid and has only minor effects on the body's mineral levels.

Celestone Soluspan

is the brand name

Enstilar Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Celestone Soluspan

Betamethasone

1965

264

Approved as Treatment by the FDA

Betamethasone, otherwise known as Celestone Soluspan, is approved by the FDA for 14 uses like Lupus Erythematosus, Discoid and Lichen Planus .

Lupus Erythematosus, Discoid

Helps manage Discoid Lupus Erythematosus (DLE)

Lichen Planus

Helps manage Lichen Planus (LP)

Psoriasis

Helps manage Psoriatic plaque

Granuloma Annulare

Helps manage granuloma annulare lesions

Keloids Scars

Helps manage Keloids Scars

Lichen simplex chronicus

Helps manage Lichen simplex chronicus

granuloma annulare lesions

Helps manage granuloma annulare lesions

Lichen Planus (LP)

Helps manage Lichen Planus (LP)

Alopecia Areata (AA)

Helps manage Alopecia Areata (AA)

Psoriatic plaque

Helps manage Psoriatic plaque

Discoid Lupus Erythematosus (DLE)

Helps manage Discoid Lupus Erythematosus (DLE)

Neurodermatitis

Helps manage Lichen simplex chronicus

Alopecia Areata

Helps manage Alopecia Areata (AA)

Necrobiosis Lipoidica

Helps manage Necrobiosis lipoidica diabeticorum

Effectiveness

How Enstilar Affects Patients

Corticosteroids are drugs that reduce inflammation and can be used to treat a wide range of conditions. The body naturally produces corticosteroids, but patients may need to take a higher dose than what is made naturally. People taking corticosteroids long-term need to be aware that it can suppress the body's natural hormone production and make them more prone to infections.

How Enstilar works in the body

Glucocorticoids like betamethasone work by reducing inflammation. They can do this through two main pathways. The first is through blocking molecules that cause inflammation, like arachidonic acid derivatives and NF-Kappa B. The second way is by promoting anti-inflammatory molecules and genes, like interleukin-10. Betamethasone also works quickly by modulating T-cell, platelet and monocyte activity.

When to interrupt dosage

The proposed dosage of Enstilar is contingent upon the determined affliction, including Ankylosing Spondylitis, Adrenal cortical hypofunctions and Post Surgical Ocular Inflammation. The amount of dosage varies, depending on the delivery technique (e.g. Topical or Solution - Oral) listed in the following table.

Condition

Dosage

Administration

Nephrotic Syndrome

, 0.5 mg/mL, 0.001 mg/mg, 1.0 mg/mL, 0.0005 mg/mg, 0.000643 mg/mg, 0.00064 mg/mg, 0.64 mg, 0.00005 mg/mg, 0.0012 mg/mg, 3.0 mg/mL, 0.64 mg/mL, 0.005 mg/mg, 12.0 mg/mL, 0.05 %, 0.1 %, 0.12 %, 0.5 mg, 0.1 mg, 1.0 mg, 0.025 %, 0.1 mg/mL, 0.6 mg, 6.0 mg, 3.0 mg, 6.0 mg/mL, 7.0 mg/mL, 0.6 mg/mL, 0.643 mg/mL, 0.00061 mg/mg, 0.05 mg/mg, 0.064 mg/mg, 0.05 mg/mL, 0.00122 mg/mg

, Topical, Lotion, Lotion - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Gel, Gel - Topical, Spray, metered, Spray, metered - Topical, Intra-articular; Intralesional; Intramuscular, Aerosol, foam, Aerosol, foam - Topical, Ointment, augmented - Topical, Ointment, augmented, Lotion, augmented, Lotion, augmented - Topical, Suspension, Suspension - Topical, Cream, augmented, Cream, augmented - Topical, Injection, solution, Injection, solution - Epidural; Intramuscular; Intraspinal; Intrathecal, Injection, suspension - Intramuscular, Epidural; Intramuscular; Intraspinal; Intrathecal, Rectal, Enema - Rectal, Tablet, effervescent, Auricular (otic); Ophthalmic, Liquid, Liquid - Auricular (otic); Ophthalmic, Spray, Spray - Topical, Patch, Patch - Topical, Intra-articular; Intrabursal; Intradermal; Intramuscular, Cutaneous, Lotion - Cutaneous, Injection, suspension - Intra-articular; Intralesional; Intramuscular, Intra-articular; Intralesional; Intramuscular; Soft tissue, Tablet, Oral, Tablet - Oral, Injection, suspension, Intramuscular, Injection, suspension - Epidural; Intramuscular; Intraspinal; Intrathecal, Enema, Solution, Solution - Auricular (otic); Ophthalmic, Tablet - Topical, Tablet, effervescent - Oral, Liquid - Topical, Solution / drops, Solution / drops - Auricular (otic); Ophthalmic, Tablet, extended release - Oral, Ointment - Ophthalmic, Tablet, extended release, Ophthalmic, Suspension - Intra-articular; Intralesional; Intramuscular, Suspension - Intra-articular; Intrabursal; Intradermal; Intramuscular, Kit, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Kit - Topical, Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural, Kit - Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural, Solution - Oral, Solution - Topical, Kit - Intra-articular; Intralesional; Intramuscular, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Kit - Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical, Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical

exfoliative erythroderma

Rhinitis, Allergic

Keratoconjunctivitis

Blepharitis

Giant Cell Arteritis

Adrenal Insufficiency

Psoriatic Arthritis

Arthritis, Juvenile

Leukemia

Asthma

Lichen Planus

Psoriasis Vulgaris

Psoriasis

Bacterial Infections

Lymphoma, Non-Hodgkin

Congenital adrenal hyperplasia

Brain Tumor

Ankylosing Spondylitis

Eye Infection

Warnings

Enstilar has one contraindication and should not be used concurrently with the conditions highlighted in the subsequent table.

Enstilar Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Enstilar.

Common Enstilar Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Betamethasone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Betamethasone is combined with Abetimus.

Enstilar Toxicity & Overdose Risk

Long-term, high doses of glucocorticoids can lead to serious side effects including cataracts, glaucoma, high blood pressure, fluid retention, high cholesterol, ulcers, pancreatitis, muscle weakness, changes in mood and behavior, thinning of the skin, increased hair growth, weakened immune system, decreased resistance to infection, facial swelling, high blood sugar, low calcium and phosphate levels, acidosis, stunted growth, and reduced activity in the adrenal glands. If someone overdoses on glucocorticoids, treatment may involve reducing the dose or stopping the drug altogether, as well as administering medications

Enstilar Novel Uses: Which Conditions Have a Clinical Trial Featuring Enstilar?

249 active clinical trials are underway to assess the potential of Enstilar in managing Eye Infections, Alopecia Areata (AA) and Verrucous Lichen Planus (LP).

Condition

Clinical Trials

Trial Phases

Lupus

63 Actively Recruiting

Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1

Conjunctivitis

0 Actively Recruiting

Rheumatoid Arthritis

63 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Brain Tumor

61 Actively Recruiting

Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3

Blepharoconjunctivitis

0 Actively Recruiting

Ulcerative Colitis

26 Actively Recruiting

Phase 3, Phase 2, Phase 1, Not Applicable, Phase 4

Eosinophilic Pneumonia

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Eye Injuries

0 Actively Recruiting

Dermatosis

0 Actively Recruiting

Sarcoidosis

0 Actively Recruiting

Bacterial Infections

0 Actively Recruiting

Arthritis, Gouty

0 Actively Recruiting

Congenital adrenal hyperplasia

7 Actively Recruiting

Phase 3, Phase 1, Phase 2

Verrucous Lichen Planus (LP)

0 Actively Recruiting

Pruritus

0 Actively Recruiting

Inflammatory Reaction of the ear

0 Actively Recruiting

Blepharitis allergic

0 Actively Recruiting

Neurodermatitis

0 Actively Recruiting

Psoriasis Vulgaris

22 Actively Recruiting

Early Phase 1, Phase 3, Phase 4, Phase 2, Not Applicable

Enstilar Reviews: What are patients saying about Enstilar?

Patient Review

12/5/2017

Enstilar for Plaque Psoriasis

I've tried so many things for my chronic skin condition, and this is the only one that's worked. It's also very affordable, which is great since insurance companies often don't cover these kinds of treatments.

Patient Review

5/29/2018

Enstilar for Plaque Psoriasis

I was amazed at how well this topical medication worked on my psoriasis! I had been prescribed it by my dermatologist to use only once a day on visible areas, and within days I could see results. My skin is now clear and I am no longer self-conscious about exposing it in public.

Patient Review

1/3/2022

Enstilar for Plaque Psoriasis

Dovobet didn't work well for me over the course of several years, but Enstilar foam showed results immediately. I was told to use it once a day for two weeks, and then only twice a week after that. Not only did the dry, dead skin stop appearing almost immediately, but the itching stopped too. The only downside is that my skin is now pink and looks red after bathing, but that's a small price to pay for being itch-free.

Patient Review

9/18/2022

Enstilar for Plaque Psoriasis

My mother, a retired nurse, has been dealing with psoriasis for 30 years. In the past two years, it's gotten worse and spread across her body. She's tried so many creams with no success. This one worked within a week--it's truly a miracle! Other steroids never did anything. If you're in the same boat, please give this treatment a try!

Patient Review

4/2/2018

Enstilar for Plaque Psoriasis

Enstilar is amazing. It's quite costly but worth every penny. I've had a severe outbreak for 6+ months and this product gave significant results in less than a week.

Patient Review

10/14/2018

Enstilar for Plaque Psoriasis

This drug is nothing short of a miracle. It cleared up my psoriasis without any adverse side effects. I can't understand why anyone would want to take other medications for this condition that suppress the immune system.

Patient Review

6/16/2021

Enstilar for Plaque Psoriasis

I've been using this foam for about four months, and it has completely gotten rid of my forehead psoriasis! It's really helped clear up my back too. I highly recommend it to anyone struggling with this awful condition.

Patient Review

12/19/2019

Enstilar for Plaque Psoriasis

I'm so thankful that my doctor prescribed this cream. My psoriasis is clearing up and I feel more confident than ever before. Finally, I can wear a swimsuit without feeling self-conscious. Thank you!

Patient Review

11/5/2021

Enstilar for Plaque Psoriasis

My dermatologist prescribed this to me, and it cleared up my arms and legs within six weeks. It's an absolute miracle, and I can't recommend it enough. Just follow the directions and you'll see amazing results!

Patient Review

9/10/2017

Enstilar for Plaque Psoriasis

I used this treatment once and, two days later, my plaque psoriasis had practically cleared up.

Patient Review

10/21/2017

Enstilar for Plaque Psoriasis

I've used a similar medication in the past with little success, but this one really worked well for me. Within just three days of using it, my psoriasis had faded significantly.

Patient Review

8/7/2018

Enstilar for Plaque Psoriasis

I've been using this medication for a little over four months now, and I can say with certainty that it has cleared up my acne by 95%.

Patient Review

4/28/2022

Enstilar for Plaque Psoriasis

Enstilar is, by far, the best psoriasis medication I've tried in the last three years. If you leave it on for two days and then have a bath, it removes scabby plaques really well. Additionally, a few 12-minute sessions on a sunbed clears up any red patches that are left behind. Just be sure to wash it off thoroughly before using a sunbed or you'll end up with bad burns!

4.7

Patient Review

8/5/2017

Enstilar for Plaque Psoriasis

I was really blown away by how well this worked.

Patient Review

4/20/2017

Enstilar for Plaque Psoriasis

While this did help get rid of the scabs on my elbows, it unfortunately didn't do much for the small red patches that have developed all over my body.

1.7

Patient Review

3/17/2019

Enstilar for Plaque Psoriasis

This shampoo makes my hair incredibly greasy. Even after several washes, the product is still clinging to my hair! I'm not sure if I'll continue using it.

Patient Q&A Section about enstilar

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long can you use Enstilar?

"Enstilar® Foam can be applied once daily across a large body area and should not exceed 60 grams every 4 days. Be sure to wash your hands before applying the foam."

Answered by AI

Is Enstilar good for psoriasis?

"The Enstilar foam can help you to get rid of the red and scaly skin which are the common symptoms of psoriasis."

Answered by AI

Is Enstilar a strong steroid?

"Clotrimazole is an antifungal drug that works by killing the fungus or preventing its growth.

This product contains Betamethasone, a very strong corticosteroid drug that works by decreasing swelling, redness, and itching, and Clotrimazole, an antifungal drug that works by killing the fungus or preventing its growth."

Answered by AI

Is Enstilar foam safe?

"The use of certain types of corticosteroid foam, including Enstilar, may increase the risk of developing posterior subcapsular cataracts or glaucoma. These conditions have been reported in people who have used such foams after they were already on the market. Therefore, it is important to avoid contact with Enstilar foam if it may come into contact with your eyes. Additionally, this foam may cause general eye irritation."

Answered by AI