Dermotic

Otitis Externa, Uveitis, Perianal erythema + 30 more

Treatment

3 FDA approvals

20 Active Studies for Dermotic

What is Dermotic

Fluocinolone acetonide

The Generic name of this drug

Treatment Summary

Fluocinolone acetonide is a corticosteroid that is used in topical skin treatments. It has also been studied for use in implantable devices to treat chronic conditions. Taro Pharmaceuticals received FDA approval for an implantable device containing fluocinolone acetonide in 2016.

Neo-Synalar

is the brand name

image of different drug pills on a surface

Dermotic Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Neo-Synalar

Fluocinolone acetonide

1963

93

Approved as Treatment by the FDA

Fluocinolone acetonide, otherwise called Neo-Synalar, is approved by the FDA for 3 uses like Chronic Uveitis and Uveitis .

Chronic Uveitis

Uveitis

Uveitis

Effectiveness

How Dermotic Affects Patients

Fluocinolone acetonide is a medication used to reduce inflammation. It is usually given as a tiny implant that is injected into the eye. Clinical trials have shown that the implant can reduce the risk of uveitis flares by twofold over six months when compared to not taking the medication. It may also cause a slight increase in intraocular pressure, so it is important to monitor this.

How Dermotic works in the body

Fluocinolone acetonide is a type of corticosteroid that works to reduce inflammation. It binds to the glucocorticoid receptor, which helps it move into the cell nucleus. There, it binds to other proteins and stops them from releasing arachidonic acid, which is a precursor to inflammatory mediators like prostaglandins and leukotrienes. This prevents these molecules from being released, reducing inflammation.

When to interrupt dosage

The proposed dosage of Dermotic is contingent upon the recognized condition, including Hemorrhoids, Perianal erythema and Itch. The quantity can be located in the table below, contingent on the technique of application (e.g. Kit or Emulsion - Topical).

Condition

Dosage

Administration

Otitis Externa

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Uveitis

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Dermatitis, Seborrheic

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Postoperative Care

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Pressure Ulcer

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Uveitis

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Skin

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Diabetic Macular Edema

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Otitis Media

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Chronic disease

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Surgery; Ear

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

postoperative treatment

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Skin Inflammation caused by Bacterial Infections

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Eczema

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Conjunctivitis, Bacterial

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Ear structure

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Wound Infection

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Perianal erythema

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Scab

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Itching

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant, Implant - Intravitreal, Shampoo, Shampoo - Topical, Solution / drops, Solution / drops - Auricular (otic), Gel, Gel - Topical, Emulsion - Topical, Emulsion, Intraocular, Implant - Intraocular

Warnings

Dermotic has four contraindications and should not be applied when afflicting any of the conditions indicated in the following table.

Dermotic Contraindications

Condition

Risk Level

Notes

Mycoses

Do Not Combine

External auditory canal structure

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Fluocinolone Acetonide may interact with conjunctiva

Severe Hypersensitivity Reactions

Do Not Combine

Fluocinolone Acetonide may interact with conjunctiva

There are 20 known major drug interactions with Dermotic.

Common Dermotic Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Fluocinolone acetonide.

Abetimus

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abetimus.

Dermotic Toxicity & Overdose Risk

There have been no studies to assess the cancer-causing potential or its effects on fertility. However, some corticosteroids have been linked to genotoxicity, but fluocinolone acetonide has not been found to be genotoxic in certain tests.

Dermotic Novel Uses: Which Conditions Have a Clinical Trial Featuring Dermotic?

97 active trials are currently investigating the potential of Dermotic oil to treat Atopic Dermatitis, Otitis Media and External Otitis.

Condition

Clinical Trials

Trial Phases

Hemorrhoids

1 Actively Recruiting

Not Applicable

Perianal erythema

0 Actively Recruiting

Eczema

0 Actively Recruiting

Blister

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Psoriasis of the scalp

1 Actively Recruiting

Phase 4

Otitis

3 Actively Recruiting

Not Applicable

Hemorrhoids

3 Actively Recruiting

Phase 4, Not Applicable

Scab

0 Actively Recruiting

Ear structure

0 Actively Recruiting

Skin

0 Actively Recruiting

Skin Diseases

0 Actively Recruiting

Fissure in Ano

0 Actively Recruiting

Postoperative Care

7 Actively Recruiting

Early Phase 1, Phase 4, Not Applicable, Phase 1

Wound Infection

9 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1

Skin Inflammation caused by Bacterial Infections

0 Actively Recruiting

Uveitis

1 Actively Recruiting

Phase 3

Conjunctivitis, Bacterial

0 Actively Recruiting

Coinfection

0 Actively Recruiting

Chronic disease

0 Actively Recruiting

Dermotic Reviews: What are patients saying about Dermotic?

5

Patient Review

4/21/2008

Dermotic for Inflammation of the External Ear Resembling Eczema

Dermotic oil is the best thing I've used for my itchy ears. It works within days and I forget that I even had a problem in the first place!

5

Patient Review

8/31/2009

Dermotic for Inflammation of the External Ear Resembling Eczema

I've had itchy, scaling ears for over 50 years. This medication worked so well that I can hardly express my results! I wish one of my dozen or so previous MDs had prescribed this for me years earlier.

5

Patient Review

1/20/2010

Dermotic for Inflammation of the External Ear Resembling Eczema

I've had chronic dry, itchy ears for years that sometimes even bled. I tried every remedy my previous doctors prescribed, to no avail. Finally, I visited an E-N-T specialist who prescribed DermOtic Oil. And it works! It stopped the itching and I don't even think about my ears anymore. The oil also leaves the skin around my ear nice and soft--no more itchiness, flakiness or bleeding. I'm very satisfied with this medication as it's the only one that's worked for me so far.

5

Patient Review

1/11/2011

Dermotic for Inflammation of the External Ear Resembling Eczema

I had been dealing with incredibly itchy ears for months before I saw an ENT. He prescribed this medication, and it's worked wonders. Not only does it relieve the itch, but it also feels good and smells great!

5

Patient Review

4/16/2019

Dermotic for Inflammation of the External Ear Resembling Eczema

I had extremely itchy ears for more than a decade, which may have been from swimming in pools regularly. This medication cured me after just three applications! I haven't needed to use it in at least a month and finally feel normal again.

5

Patient Review

5/30/2011

Dermotic for Inflammation of the External Ear Resembling Eczema

I am so glad I finally tried this treatment. It worked much faster than I could have ever imagined and has completely stopped my itchy ears.

5

Patient Review

2/3/2008

Dermotic for Inflammation of the External Ear Resembling Eczema

This was perfect for when my ears felt sore from wearing hearing aids. I just used it as needed and it worked great.

5

Patient Review

12/17/2011

Dermotic for Inflammation of the External Ear Resembling Eczema

This cleared up my itchy, crusty, inflamed ears in just two days!

5

Patient Review

5/5/2012

Dermotic for Inflammation of the External Ear Resembling Eczema

This treatment worked wonders for my itchy ears. I'm so grateful to have found something that works so well and so quickly.

5

Patient Review

8/16/2015

Dermotic for Inflammation of the External Ear Resembling Eczema

This oil is super effective for me. After just one or two applications, my ear was noticeably dryer and the itching completely stopped.

3.7

Patient Review

10/24/2007

Dermotic for Inflammation of the External Ear Resembling Eczema

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dermotic

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Dermotic

Image of Ann & Robert H. Lurie Children's Hospital of Chicago in Chicago, United States.

Postoperative Pacing for Heart Surgery

< 18
All Sexes
Chicago, IL

The goal of this study is to determine whether temporarily increasing a child's heart rate after heart surgery can improve blood flow and oxygen supply to the body's tissues. The study will compare temporary atrial pacing at 10 and 20 beats per minute above the child's natural heart rate with the child's natural heart rate without pacing. Participants will be randomly assigned to one of two schedules for these pacing approaches. Each pacing approach has previously been used as part of routine care after heart surgery. The study will test whether temporarily increasing the heart rate improves blood flow and oxygen supply during the first 10 hours after surgery.

Recruiting
Has No Placebo

Ann & Robert H. Lurie Children's Hospital of Chicago

Robert G Webster, MD, MPH

Image of The Ottawa Hospital Civic Campus in Ottawa, Canada.

Tranexamic Acid for Wound Complications

18+
All Sexes
Ottawa, Canada

Patients who undergo total ankle replacement surgery can sometimes develop problems with wound healing after their operation. These complications may include delayed healing, wound opening, or infection, which can lead to additional clinic visits, further surgery, and longer recovery times. Tranexamic acid (TXA) is a medication that has been used safely for many years in many types of surgery to reduce bleeding. Some studies suggest that it may also improve wound healing after foot and ankle surgery by reducing bleeding and swelling around the surgical site. However, there is not enough high-quality evidence to know whether TXA truly improves outcomes for patients undergoing total ankle replacement. This study is a pilot clinical trial designed to determine whether a larger study can be successfully carried out. Approximately 40 patients undergoing total ankle replacement surgery at The Ottawa Hospital will be randomly assigned to receive either TXA or a placebo (salt water solution). Neither the patients nor their health care team will know which treatment was given until the study is complete. All patients will receive standard surgical care and follow-up regardless of which group they are assigned to. Researchers will then collect information about wound healing, complications, additional surgeries, and infections at routine follow-up visits for up to six months after surgery. The outcomes will be compared between patients in each group. The results of this pilot study will help determine whether a larger clinical trial is feasible and may provide early information about whether TXA could improve recovery after total ankle replacement surgery. Ultimately, this research aims to improve patient outcomes and reduce complications following ankle replacement surgery.

Phase 2
Waitlist Available

The Ottawa Hospital Civic Campus

Bradley Meulenkamp, MD MSc FRCSC

Have you considered Dermotic clinical trials?

We made a collection of clinical trials featuring Dermotic, we think they might fit your search criteria.
Go to Trials
Image of Kingston Health Sciences Centre in Kingston, Canada.

Prehabilitation for Ovarian Cancer Surgery

18+
Female
Kingston, Canada

The goal of this clinical trial is to learn whether high-dose multimodal prehabilitation, delivered either in person or remotely with coaching and web application support, is feasible and acceptable for women preparing for primary surgery for suspected gynecologic malignancy. It will also examine which delivery model patients prefer and the factors influencing patient preferences. The main questions ADAPT aims to answer are: 1. Can participants achieve the prescribed aerobic exercise target of at least 10 MET-hours per week before surgery? 2. Do patients prefer in-person prehabilitation, remote prehabilitation, or education-only care, and what factors influence that preference? The researchers will compare in-person prehabilitation, remote prehabilitation, and education-only care to see which delivery approach is most feasible, acceptable, and practical for patients with suspected gynecologic cancer. Participants will: * Choose their preferred study group, or be randomly assigned if they have no preference * Complete patient-reported questionnaires and semi-structured interviews at baseline, 1-3 days before surgery, and 4 weeks after surgery * If assigned to a prehabilitation group, complete aerobic exercise, protein supplementation, and daily breathing exercises before surgery * Attend weekly coaching sessions with a trained prehabilitation coach * Use the KingstonPrehab web application to track exercise, nutrition, breathing practice, and progress toward activity goals

Recruiting
Has No Placebo

Kingston Health Sciences Centre

Jordan Leitch, MSc, MD, FRCPC

Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Prehabilitation Program for Elective Surgery

18+
All Sexes
Hamilton, Canada

The goal of this clinical trial is to learn if a virtually monitored, home-based prehabilitation program is feasible and acceptable for adults undergoing major elective surgery. The main questions it aims to answer are: 1. Can researchers successfully recruit and retain participants across multiple sites? 2. Will participants adhere to the prehabilitation program at a high enough rate to justify a larger trial? Researchers will compare the prehabilitation program to standard preoperative care to see if the intervention is feasible to implement and whether it may help reduce postoperative complications. Participants will: * Be randomly assigned to receive either the prehabilitation program or usual care * Complete questionnaires and physical assessments before and after the intervention * (For those in the intervention group) Receive exercise, nutrition, and mindfulness guidance, protein supplements, and use the CloudDX virtual care platform to support their activities

Waitlist Available
Has No Placebo

St. Joseph's Healthcare Hamilton (+2 Sites)

Jordan Leitch, MSc, MD, FRCPC

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Image of Associated Retina Consultants, Ltd. in Phoenix, United States.

BI 3812465 for Diabetic Macular Edema

18+
All Sexes
Phoenix, AZ

This study is open to adults with diabetic macular edema that involves the center of the eye. The purpose of this study is to find out how well different doses of a medicine called BI 3812465 are tolerated by people with this condition. This is the first time BI 3812465 is given to humans. This study has 2 parts. In Part 1, a small number of participants receive low, medium, or high doses of BI 3812465. The first participants to start the study get low doses of BI 3812465. Participants who start later get higher doses only if the lower doses were tolerated. In Part 2, a larger number of participants are placed into low, medium, or high dose groups. Participants in both parts of the study get BI 3812465 as injections into the back of the eye for a total of 3 eye injections. Participants are in the study for up to 7 months. During this time, they visit the study site 19 times. Where possible, some visits can be done at the participant's home instead of the study site. At study visits, the doctors check the severity of participants' eye condition and note any health problems that could have been caused by BI 3812465.

Phase 1 & 2
Recruiting

Associated Retina Consultants, Ltd. (+33 Sites)

Boehringer Ingelheim

Image of OU Health - Burn Unit in Oklahoma City, United States.

Methylene Blue-Photodynamic Therapy for Burns

18+
All Sexes
Oklahoma City, OK

Burn wound infections remain a major source of morbidity in patients with thermal injuries and contribute to delayed healing, graft loss, and prolonged hospitalization. The emergence of antimicrobial-resistant organisms further complicates management and highlights the need for non-antibiotic antimicrobial strategies. Photodynamic therapy (PDT) is an antimicrobial approach that combines a photosensitizing agent with visible light to generate reactive oxygen species capable of killing bacteria. This randomized clinical trial will evaluate the safety and preliminary efficacy of methylene blue-mediated photodynamic therapy for the treatment of burn wound bacterial contamination. Participants receiving standard burn care will be randomized to receive either methylene blue-photodynamic therapy with blue light illumination or light therapy alone during routine dressing changes. Treatments will occur during two consecutive dressing changes. The primary objective is to determine whether methylene blue photodynamic therapy reduces bacterial burden in burn wounds compared with light therapy alone. Secondary outcomes include safety, tolerability, and effects on wound healing.

Phase < 1
Waitlist Available

OU Health - Burn Unit

Nicole A. Wilson, PhD, MD

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