Postoperative Pacing for Heart Surgery
(POSTPACE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to determine whether temporarily increasing a child's heart rate after heart surgery can improve blood flow and oxygen supply to the body's tissues. The study will compare temporary atrial pacing at 10 and 20 beats per minute above the child's natural heart rate with the child's natural heart rate without pacing.
Participants will be randomly assigned to one of two schedules for these pacing approaches. Each pacing approach has previously been used as part of routine care after heart surgery. The study will test whether temporarily increasing the heart rate improves blood flow and oxygen supply during the first 10 hours after surgery.
Who Is on the Research Team?
Robert G Webster, MD, MPH
Principal Investigator
Ann & Robert H Lurie Children's Hospital of Chicago
Are You a Good Fit for This Trial?
This trial is for children who have just had congenital heart surgery. It excludes those with conditions that would make temporary pacing unsafe or not possible, but specific exclusions are not listed.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Temporary Atrial Pacing
Trial Overview
The study tests if temporarily increasing a child's heart rate using atrial pacing after heart surgery improves blood flow and oxygen delivery compared to no pacing. Children are randomly assigned to different pacing schedules during the first 10 hours after surgery.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants first undergo temporary atrial pacing at 20 beats per minute above the intrinsic sinus rate, followed by atrial pacing at 10 beats per minute above the intrinsic sinus rate and then intrinsic sinus rhythm without protocol-directed atrial pacing. Each condition is maintained for approximately three hours.
Participants first undergo intrinsic sinus rhythm without protocol-directed atrial pacing, followed by temporary atrial pacing at 20 beats per minute above the intrinsic sinus rate and then 10 beats per minute above the intrinsic sinus rate. Each condition is maintained for approximately three hours.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Robert G. Webster, MD, MPH
Lead Sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Collaborator
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