Acular Ls

Eye Pain, Inflammation, corneal refractive surgery + 20 more

Treatment

2 FDA approvals

20 Active Studies for Acular Ls

What is Acular Ls

Ketorolac

The Generic name of this drug

Treatment Summary

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain. It comes in the form of tablets, injections, nasal spray, and eye drops. Ketorolac is commonly used to treat postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. It works as well as morphine and meperidine but without the side effects of opioids.

Toradol

is the brand name

image of different drug pills on a surface

Acular Ls Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Toradol

Ketorolac

1991

316

Approved as Treatment by the FDA

Ketorolac, also called Toradol, is approved by the FDA for 2 uses like caudal epidural block therapy and induction of Nerve Block .

caudal epidural block therapy

Used to treat caudal epidural block therapy in combination with Bupivacaine

induction of Nerve Block

Used to treat induction of Nerve Block in combination with Bupivacaine

Effectiveness

How Acular Ls Affects Patients

Ketorolac is a non-selective painkiller that works by blocking the enzymes responsible for producing substances that contribute to inflammation and pain. Blocking the COX-1 enzyme can lead to an increased risk of bleeding and stomach ulcers, while blocking the COX-2 enzyme is what causes the desired anti-inflammatory and pain relief effects. However, it is not recommended to take ketorolac long-term as this can lead to dangerous side effects such as stomach bleeding, ulcers, and perforations.

How Acular Ls works in the body

Ketorolac helps reduce pain and inflammation by blocking the pathways that create prostaglandins. It works by targeting two enzymes, COX-1 and COX-2, but mainly works on the COX-2 enzyme. This enzyme is responsible for converting arachidonic acid into prostaglandins, which cause inflammation and pain. By blocking this pathway, ketorolac stops the creation of these prostaglandins and reduces pain and inflammation. It is usually given as a racemic mixture, but the "S" enantiomer is mainly responsible for its effects.

When to interrupt dosage

The prescribed measure of Acular Ls is contingent upon the indicated condition, including Eye, Macular Edema, Cystoid and Pericarditis Acute. The magnitude of dosage is subject to the method of administration (e.g. Tablet - Oral or Ophthalmic) delineated in the following table.

Condition

Dosage

Administration

Miosis disorder

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Ocular Itching

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Seasonal Allergic Conjunctivitis

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Macular Edema, Cystoid

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

induction of Local Anaesthesia

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Eye Pain

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Cataract Surgery

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Intraocular Lens Replacement

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Macular Edema, Cystoid

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

postoperative ocular pain

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Pain

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

caudal epidural block therapy

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Macular Edema

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Acute Coryza

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Pupil

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

induction of Nerve Block

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Pericarditis Acute

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Inflammation

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

corneal refractive surgery

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Induced Hyperthermia

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Kit - Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate

Warnings

Acular Ls Contraindications

Condition

Risk Level

Notes

Heart failure

Do Not Combine

Hyperkalemia

Do Not Combine

Renal Insufficiency

Do Not Combine

Hemorrhagic Disorders

Do Not Combine

Kidney Failure

Do Not Combine

A History of Gastric or Duodenal Ulcers

Do Not Combine

Liver Diseases

Do Not Combine

Major Surgery

Do Not Combine

Pulse Frequency

Do Not Combine

Gastrointestinal Hemorrhage

Do Not Combine

Crohn's Disease

Do Not Combine

suspected cerebrovascular bleeding

Do Not Combine

active Gastrointestinal Bleeding

Do Not Combine

NSAID-Induced Asthma

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

incomplete hemostasis

Do Not Combine

Coronary Artery Bypass Grafting

Do Not Combine

Gastrointestinal Perforation

Do Not Combine

Pulse Frequency

Do Not Combine

Hemorrhage

Do Not Combine

Peptic Ulcer

Do Not Combine

Pulse Frequency

Do Not Combine

Labour

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Third trimester of pregnancy

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Ketorolac may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Ketorolac may interact with Pulse Frequency

There are 20 known major drug interactions with Acular Ls.

Common Acular Ls Drug Interactions

Drug Name

Risk Level

Description

Aceclofenac

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Aceclofenac.

Acemetacin

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Acemetacin.

Acetylsalicylic acid

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Acetylsalicylic acid.

Alclofenac

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Alclofenac.

Alminoprofen

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Alminoprofen.

Acular Ls Toxicity & Overdose Risk

Taking ketorolac may cause abdominal pain, indigestion, nausea, and headaches in more than 10% of patients. Other common symptoms of an overdose include vomiting, epigastric pain, gastrointestinal bleeding, fatigue and drowsiness, kidney damage or failure, high blood pressure, and coma. Women who are pregnant or nursing should exercise caution when taking ketorolac as it can be passed through breast milk and may cause premature closure of the fetal ductus arteriosus. Women who are trying to conceive should avoid taking ketorolac as it may affect fertility.

image of a doctor in a lab doing drug, clinical research

Acular Ls Novel Uses: Which Conditions Have a Clinical Trial Featuring Acular Ls?

188 active clinical trials are presently analyzing the potential of Acular LS to ameliorate Macular Edema, Cystoid, acute, moderate Pain and Intraocular Lens Replacement.

Condition

Clinical Trials

Trial Phases

Inflammation

61 Actively Recruiting

Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 1

Induced Hyperthermia

0 Actively Recruiting

caudal epidural block therapy

4 Actively Recruiting

Not Applicable, Phase 4, Phase 3

Intraocular Lens Replacement

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Macular Edema, Cystoid

0 Actively Recruiting

induction of Nerve Block

0 Actively Recruiting

Pupil

0 Actively Recruiting

Local Anaesthesia therapy

0 Actively Recruiting

corneal refractive surgery

0 Actively Recruiting

Seasonal Allergic Conjunctivitis

0 Actively Recruiting

Eye Pain

1 Actively Recruiting

Phase 4

postoperative ocular pain

0 Actively Recruiting

Eye

0 Actively Recruiting

Ocular Itching

0 Actively Recruiting

Pericarditis Acute

1 Actively Recruiting

Phase 2, Phase 3

Miosis disorder

0 Actively Recruiting

Macular Edema, Cystoid

0 Actively Recruiting

Macular Edema

1 Actively Recruiting

Phase 1, Phase 2

Cataract Surgery

2 Actively Recruiting

Not Applicable, Phase 4

Acular Ls Reviews: What are patients saying about Acular Ls?

5

Patient Review

3/11/2008

Acular Ls for Postoperative Pain in Eye

This medication has a bit of a burning sensation upon application, but it subsides quickly.

5

Patient Review

8/12/2008

Acular Ls for Eye Irritation

This medicine is amazing! I had a scratch at the back of my eye that was causing me so much pain, but after taking this it just vanished. Best sleep ever!

3

Patient Review

10/27/2008

Acular Ls for Inflammation of the Eye Following Surgery

About a week after my cataract surgery, I started using this treatment four times daily. The day after I stopped, I developed throbbing and redness in the affected eye, as well as tearing. I'm seeing my eye surgeon tomorrow, but in the meantime, does anyone know if this is normal?

1.7

Patient Review

6/17/2009

Acular Ls for Eye Irritation

I was very disappointed with this treatment. It did nothing to ease my pain, even temporarily, and it was quite expensive.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about acular ls

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long can you use ACULAR eye drops?

"The recommended length of use for ACULAR® eye drops is 2-4 weeks, as prescribed by a doctor."

Answered by AI

What is Acular LS used for?

"NSAIDs are a type of medication used to relieve pain, burning, and stinging. Ketorolac is a specific NSAID that is used to relieve symptoms following corneal refractive surgery."

Answered by AI

Are ACULAR eye drops an antibiotic?

"Acular is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve itching in the eyes that is caused by seasonal allergies. Acular is also used to reduce swelling, pain, and burning or stinging after cataract surgery or corneal refractive surgery."

Answered by AI

Is ACULAR eye drops a steroid?

"Acular (ketorolac eye drops) belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs), which is different from steroids. Even though they are different types of drugs, steroids and NSAIDs are often used for similar conditions, such as eye pain or inflammation."

Answered by AI

Clinical Trials for Acular Ls

Image of Texas Tech University Health Sciences Center/ University Medical Center Lubbock in Lubbock, United States.

PSP Monitoring for Sepsis in Burns

18 - 89
All Sexes
Lubbock, TX

The goal of this clinical trial is to learn if using pancreatic stone protein (PSP) test results helps doctors find and treat sepsis earlier in adults with serious burn injuries. The study will also look at whether using PSP is safe and practical in the burn intensive care unit. The main questions it aims to answer are: * Does seeing PSP test results help doctors start the right antibiotics sooner? * Does using PSP reduce unnecessary antibiotic use? * Does using PSP improve recovery and other health outcomes? Researchers will compare two groups of patients. One group will receive standard care, and their PSP test results will be hidden from their care team. The other group will receive standard care, but their care team will be able to see the PSP test results and use them to help make treatment decisions. Participants will: * Be randomly assigned to one of the two study groups. * Have a small blood sample taken within 24 hours after being admitted to the burn ICU and then once each weekday while they are in the ICU. * Receive the usual care for burn injuries and sepsis throughout the study.

Waitlist Available
Has No Placebo

Texas Tech University Health Sciences Center/ University Medical Center Lubbock

Brian Schneider, MD

Abionic SA

Image of Nicholas Institute of Sports Medicine & Athletic Trauma (NISMAT) in New York, United States.

Fruit Juice for Inflammation

18 - 65
All Sexes
New York, NY

Dietary patterns and physical inactivity common in Western societies have been associated with chronic low-grade inflammation and an increased risk of non-communicable health conditions. Fruits and vegetables contain polyphenols and other bioactive compounds that may have antioxidant and anti-inflammatory properties and may influence inflammatory biomarkers. This study will evaluate the effects of increased consumption of a fruit juice on inflammatory biomarkers and exercise capacity in adults with mildly elevated inflammation. Approximately 40 participants will be randomly assigned to consume one of two fruit juice interventions daily for approximately 2 weeks. Changes in C-reactive protein (CRP) and exercise capacity, assessed using a 6-minute walk test, will be evaluated before and after the intervention and compared between the two groups.

Recruiting
Has No Placebo

Nicholas Institute of Sports Medicine & Athletic Trauma (NISMAT)

Christopher Tanayan, MD

Image of The University of South Florida in Tampa, United States.

Acoltremon for Dry Eye Syndrome

18+
All Sexes
Tampa, FL

This study is designed to provide clinical data on how acoltremon ophthalmic solution 0.003% affects tear production and ocular symptoms in participants with tear deficiency and concurrent neuropathic corneal pain. Acoltremon is formulated to help increase natural tear production by activating TRPM8 (Transient Receptor Potential Melastatin 8) receptors on cold-sensitive corneal nerves. It is thought that this study treatment may help participants by increasing tear production while potentially reducing neuropathic ocular symptoms, including pain and discomfort. Participants will be followed for 8 weeks, evaluating the mean change in unanesthetized Schirmer test score between 3 minutes post-drop at Week 8 compared to pre-drop at baseline (Day 1), change in neuropathic symptom intensity as measured by a 0-10 VAS (Visual Analog Scale) from baseline to Week 8, and change in quality of life as assessed by the Ocular Pain Assessment Survey (OPAS) from baseline to Week 8. The study will also evaluate changes in corneal nerve structure, nerve function, corneal sensitivity, ocular surface symptoms, and treatment satisfaction.

Phase 4
Waitlist Available

The University of South Florida

Pedram Hamrah, MD

Alcon Research

Have you considered Acular Ls clinical trials?

We made a collection of clinical trials featuring Acular Ls, we think they might fit your search criteria.
Go to Trials
Image of Kannarr Eye Care in Pittsburg, United States.

Lacrifill for Dry Eye Syndrome

18 - 80
All Sexes
Pittsburg, KS

Dry Eye Disease is defined as "a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface.' 'By the The Tear Film and Ocular Surface Society. Despite there being a number of factors that impact DED however one factor that has been considered likely is that of a complication from ocular surgery itself. Which can cause both corneal nerve, and ocular surface damage. Therefore this study aims to determine how Lacrfill performs in preventing post-operative dry eye symptoms in those who have recently had unilateral cataract surgery.

Phase 4
Recruiting

Kannarr Eye Care (+1 Sites)

Image of London Regional Health Science Centre in London, Canada.

Genistein for Cardiovascular Health in HIV

18 - 80
All Sexes
London, Canada

People living with HIV (PLHIV) live longer because of modern HIV medicines, but even with these treatments, their bodies are more inflamed. Long term inflammation increases the risk of heart disease, chronic pain, lung disease, dementia, arthritis, and other infections. Because some anti-inflammatory medicines can cause serious side effects, interact with HIV drugs, or be costly, safer and more affordable treatment options are needed. Genistein is a natural compound found in soy foods. It is considered safe and has been shown to reduce inflammation and improve blood vessel health. This study will test whether genistein can lower inflammation in the blood, improve blood vessel health, and reduce pain in PLHIV.

Phase 1 & 2
Waitlist Available

London Regional Health Science Centre

Mark JK Chandy, MD PhD

Greenstone Biosciences, Inc.

Image of University of Utah in Salt Lake City, United States.

Metformin for Muscle Weakness

18+
All Sexes
Salt Lake City, UT

The purpose of this research study is to determine if Metformin taken after anterior cruciate ligament reconstruction (ACLR) surgery can decrease muscle fibrosis, cellular senescence and improve leg strength. ACL injury and surgery increase muscle collagen content and inflammation which slows the recovery of muscle and function and ultimately impacts the quality of life. Individuals enrolled in the study will be randomized to receive metformin (or placebo) for 4 months after surgery. The investigators will measure muscle strength and inflammatory markers in muscle biopsy samples after the intervention period. Investigators will also follow up with participants 8 months later to determine the lasting effects of the intervention.

Phase < 1
Waitlist Available

University of Utah

Micah Drummond

Image of Reichwald Health Sciences Centre in Kelowna, Canada.

Broccoli Sprout Extract + Exercise for Inflammation

19 - 35
All Sexes
Kelowna, Canada

The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period. One of the interventions consists of 4 days of daily supplementation with the commercially available broccoli sprout extract capsules (BrocElite). Another intervention will consist of 4 days of daily supervised treadmill running. The exercise protocol consists of 4 minutes of high-intensity running running followed by a 3 minute recovery period, repeated for a total of 4 repetitions. The last intervention combines the above two and consists of 4 days of daily supplementation and daily supervised exercise training. Before and after each intervention, basic anthropometrics (weight, heart rate, and blood pressure) will be recorded, and a venous blood sample will be collected. Blood samples will be analyzed for metabolic and inflammatory markers. Participants will be asked to refrain from structured exercise, alcohol consumption, and broccoli consumption during each of the experimental periods. Before any testing, willing participants will provide informed consent, and fill out a few demographic, and lifestyle questionnaires. The study will be conducted at the University of British Columbia in Kelowna, BC, Canada.

Recruiting
Has No Placebo

Reichwald Health Sciences Centre

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We made a collection of clinical trials featuring Acular Ls, we think they might fit your search criteria.
Go to Trials
Image of University of Oklahoma Health Campus in Oklahoma City, United States.

Disulfiram for Rheumatoid Arthritis

18 - 75
All Sexes
Oklahoma City, OK

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation. Obesity is common among individuals with RA and is associated with increased disease activity, reduced treatment response, and worse functional outcomes. Inflammation in adipose tissue, driven in part by activation of the NLRP3 inflammasome and downstream gasdermin D (GSDMD)-mediated pathways, may contribute to systemic inflammation and RA disease severity. Disulfiram (DSF), an FDA-approved medication for alcohol use disorder, has recently been identified as an inhibitor of GSDMD-mediated inflammatory signaling and pyroptosis. Preclinical studies suggest that DSF reduces inflammasome activation, inflammatory cytokine release, and metabolic dysfunction. This study is a 12-week, randomized, double-blind, placebo-controlled pilot trial designed to evaluate the safety, tolerability, and preliminary efficacy of DSF in overweight and obese adults with active RA despite stable disease-modifying antirheumatic drug (DMARD) therapy. Participants will be randomized to receive either DSF (250 mg daily) or placebo. The primary objective is to assess safety and tolerability. Secondary and exploratory objectives include evaluating the effects of DSF on systemic inflammation, RA disease activity, metabolic parameters, and adipose tissue inflammasome activation. Findings from this study will inform the feasibility and design of larger clinical trials targeting GSDMD-mediated inflammation in RA.

Phase 2
Waitlist Available

University of Oklahoma Health Campus

Beatriz Y Hanaoka, MD, MSc

Image of University of California, Riverside in Riverside, United States.

Acetazolamide for Altitude Sickness

18 - 65
All Sexes
Riverside, CA

High altitude travel can lead to inflammation in the body and activation of innate immune cells. The investigators' prior research demonstrates that 1 to 3 days at 3800 m elevation leads to increased expression of genes in blood cells that code for proteins that signal cell damage (damage associated molecular patterns (DAMPs)), cell receptors involved in innate immune responses, as well as increases in monocyte and neutrophil cells which promote inflammation. This study will investigate the potential mechanisms underlying these effects using the drug Acetazolamide, a carbonic anhydrase inhibitor which is known to reduce symptoms of Acute Mountain Sickness.

Phase < 1
Waitlist Available

University of California, Riverside

Have you considered Acular Ls clinical trials?

We made a collection of clinical trials featuring Acular Ls, we think they might fit your search criteria.
Go to Trials