Temperature & Humidity Exposure for Asthma
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical study is to learn how different temperature and humidity conditions affect breathing, lung function, exercise capacity, symptoms, and other physical responses in children and youth aged 11 to 18 years with asthma, compared with age- and sex-matched children and youth without asthma.
The main questions it aims to answer are:
* How do different temperature and humidity conditions affect lung function, breathing symptoms, exercise capacity, and physiological responses in children and youth with asthma?
* Do children and youth with asthma respond differently to these environmental conditions than children and youth without asthma?
* Do sex and gender influence these responses?
Researchers will compare children and youth with asthma to age- and sex-matched children and youth without asthma to see if temperature and humidity exposures have different effects on breathing, exercise performance, symptoms, and physiological responses.
Participants will:
* Attend two study visits in a climate-controlled chamber.
* Be exposed to hot, cold, and varying humidity conditions for short periods of time.
* Complete breathing tests and exercise testing before, during, and after each exposure.
* Have symptoms, physical activity, and physiological responses monitored throughout the study.
Are You a Good Fit for This Trial?
This trial is for children and teens aged 11 to 18, both with and without asthma. Participants must be healthy enough to do exercise testing and able to attend two study visits in a climate-controlled chamber.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Controlled Temperature and Humidity Exposure
Trial Overview
The study tests how different temperatures and humidity levels affect breathing, lung function, symptoms, and exercise ability in youth with asthma compared to those without. All participants are exposed to hot, cold, and humid conditions during monitored sessions.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Children and youth aged 11 to 18 years with asthma will be exposed to five controlled temperature and humidity conditions (ideal, cold dry, cold humid, hot dry, and hot humid) in a climatic chamber. Lung function, breathing symptoms, exercise capacity, and physiological responses will be measured before, during, and after each exposure.
Age- and sex-matched children and youth without asthma will undergo the same environmental exposures and assessments as the asthma group to allow comparison of responses between groups.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Ontario Institute of Technology
Lead Sponsor
The Hospital for Sick Children
Collaborator
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