Metrogel-Vaginal

Pouchitis, Liver Abscess, Amebic, Lung Abscess + 53 more

Treatment

41 FDA approvals

20 Active Studies for Metrogel-Vaginal

What is Metrogel-Vaginal

Metronidazole

The Generic name of this drug

Treatment Summary

Metronidazole is a prescription antibiotic used to treat various infections. It belongs to the nitroimidazole family of antibiotics and is effective in treating bacterial and parasitic infections, such as trichomoniasis, giardiasis, amebiasis, and gastrointestinal infections. Metronidazole is available as a pill, capsule, topical cream, and suppository. It has been used for decades to treat infections and continues to be an effective treatment option.

Flagyl

is the brand name

image of different drug pills on a surface

Metrogel-Vaginal Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Flagyl

Metronidazole

1963

449

Approved as Treatment by the FDA

Metronidazole, commonly known as Flagyl, is approved by the FDA for 41 uses including Liver Abscess and Communicable Diseases .

Liver Abscess

Communicable Diseases

Osteomyelitis

Abdominal Abscess

Abdominal Infection

Lung Abscess

Endometritis

hepatic abscess

Tubo-ovarian abscess

Lung Abscess

Curling Ulcer

Used to treat Duodenal Ulcer in combination with Bismuth subsalicylate

Central Nervous System Bacterial Infections

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Bismuth subsalicylate

Bacterial Meningitis

Pneumonia

intra-abdominal bacterial infections

Bacterial Endocarditis

Skin and skin structure infections

Gynaecological infection

Bone and Joint Infections

Abscess

Lower respiratory tract infection bacterial

Bacterial Septicemia

Bacteria, Anaerobic

Bacterial Infections

Duodenal Ulcer

Used to treat Duodenal Ulcer in combination with Bismuth subsalicylate

Meningitis

Abscess, Intra-Abdominal

Empyema

asymptomatic Trichomoniasis

Exposure via partner

Endomyometritis

Bacterial Peritonitis

Central Nervous System Bacterial Infections

Empyema

Trichomonas Infections

Endometritis

Endometritis

Bacteria

Endocarditis, Bacterial

Communicable Diseases

Effectiveness

How Metrogel-Vaginal Affects Patients

Metronidazole is used to treat certain bacterial and parasitic infections, including amebiasis, trichomoniasis, and giardiasis. It is effective against most anaerobic bacteria, but not against facultative anaerobes or obligate aerobes. This is because it damages the DNA of the microbes it targets. It is important to be aware that taking metronidazole can cause convulsions and peripheral neuropathy, especially at higher doses. If these symptoms occur, the drug should be stopped immediately. Additionally, it has been found to be carcinogenic in mice and rats. The effects on humans

How Metrogel-Vaginal works in the body

Metronidazole works by entering cells and breaking down into toxic metabolites. These metabolites can damage the DNA of certain organisms, like anaerobic bacteria and protozoans. Metronidazole is only toxic to these organisms because of the difference in their electron transport systems. When the nitro group of metronidazole is reduced by ferredoxin or flavodoxin, it creates toxic metabolites that can damage the DNA of the target organisms.

When to interrupt dosage

The dose of Metrogel-Vaginal is contingent upon the determined condition, including Exposure via partner, Skin and Curling Ulcer. The measure likewise differs depending on the method of delivery (e.g. Capsule or Vaginal) featured in the table beneath.

Condition

Dosage

Administration

Tubo-ovarian abscess

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Bacterial Meningitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Exposure via partner

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Abscess

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Atopic Dermatitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Bacteria

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Pneumonia

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Rosacea

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Sinusitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Trichomonas Infections

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Operative Surgical Procedures

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Lockjaw

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Pouchitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

entamoeba histolytica

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Abdominal Infection

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Endocarditis, Bacterial

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Vaginitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Bacterial Septicemia

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Curling Ulcer

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Giardiasis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Cream, Cream - Topical, Vaginal, Suppository - Vaginal, Suppository, Tablet, extended release - Oral, Tablet, extended release, Lotion, Suppository - Rectal, Rectal, Cream - Vaginal, Gel - Vaginal, Lotion - Topical, Kit, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert

Warnings

Metrogel-Vaginal has three contraindications and should not be utilized if you are experiencing any of the conditions in the following table.

Metrogel-Vaginal Contraindications

Condition

Risk Level

Notes

Pregnancy Trimester, First

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Metronidazole may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Metronidazole may interact with Pulse Frequency

There are 20 known major drug interactions with Metrogel-Vaginal.

Common Metrogel-Vaginal Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Metronidazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Metronidazole.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Metronidazole.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Metronidazole.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Metronidazole.

Metrogel-Vaginal Toxicity & Overdose Risk

The toxic dose of metronidazole in rats is 5000mg/kg. Overdosing on metronidazole can cause symptoms like nerve damage, brain toxicity, seizures, an unpleasant reaction if combined with alcohol, dark urine, a bad taste in the mouth, nausea, stomach pain, and dizziness, as well as a decrease in white blood cells. If someone overdoses on this drug, activated charcoal can help remove it from the body and poison control centers should be contacted for additional guidance.

image of a doctor in a lab doing drug, clinical research

Metrogel-Vaginal Novel Uses: Which Conditions Have a Clinical Trial Featuring Metrogel-Vaginal?

179 active studies are examining the potential of Metrogel-Vaginal to mitigate Curling Ulcer, Periodontitis and Central Nervous System Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Lockjaw

0 Actively Recruiting

Uterine Cervical Erosion

0 Actively Recruiting

Gum Disease

4 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Abdominal Infection

0 Actively Recruiting

Rosacea

0 Actively Recruiting

Balantidiasis

0 Actively Recruiting

Empyema

1 Actively Recruiting

Phase 4

Abdominal Abscess

0 Actively Recruiting

Bacteria

0 Actively Recruiting

Trichomonas Infections

0 Actively Recruiting

Vulvovaginitis

0 Actively Recruiting

Lung Abscess

0 Actively Recruiting

Pouchitis

4 Actively Recruiting

Early Phase 1, Phase 4, Phase 2

Atopic Dermatitis

17 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 4, Phase 1

Acne Vulgaris

0 Actively Recruiting

Operative Surgical Procedures

0 Actively Recruiting

Liver Abscess, Amebic

0 Actively Recruiting

Trichomonas Vaginitis

1 Actively Recruiting

Phase 4

Amebic colitis

0 Actively Recruiting

Rosacea

3 Actively Recruiting

Early Phase 1, Phase 2, Not Applicable

Metrogel-Vaginal Reviews: What are patients saying about Metrogel-Vaginal?

5

Patient Review

10/5/2015

Metrogel-Vaginal for Vaginosis caused by Bacteria

I have BV because of the foul smell when I urinate. As much as I try avoiding to go to gyn, the only thing that takes care of this problem for me is this medicine. It works by the second day, but I take the full five day course 1x/day so it stays at bay for a while. The cottage cheese discharge while using the medicine is normal and I also experience light cramping after tbe third day til I am done with the medicine

5

Patient Review

7/29/2019

Metrogel-Vaginal for Vaginosis caused by Bacteria

I just completed a five-day treatment of this medication and I'm already feeling so much better. I experienced some cramping on day three, as well as the discharge that indicates the medication is working, but those were really the only side effects I noticed.

4.3

Patient Review

10/31/2018

Metrogel-Vaginal for Vaginosis caused by Bacteria

I experienced a lot of pain and cramping while using this treatment. I also had stomach issues and a lot of discharge. The burning sensations and pressure were also very unpleasant. Overall, I hope it worked but it was definitely not a pleasant experience.

4.3

Patient Review

10/25/2022

Metrogel-Vaginal for Vaginosis caused by Bacteria

Some people will complain about anything, but the gel is actually working if you're experiencing clumping of your vaginal discharge. I've had wine while using it with no negative consequences, and it takes away BV after just five days. If you want to be productive, get your male partners treated for BV while you're getting treated yourself.

4

Patient Review

2/4/2016

Metrogel-Vaginal for Vaginosis caused by Bacteria

I was pleasantly surprised that there wasn't any discomfort when inserting the medication. It didn't leak out, even when I was standing up (although I used it before bed and tried to stay lying down). Currently on day 4, symptoms for BV are gone, now just worried about a possible yeast infection after reading the reviews! Eating lots of yogurt in the meantime. Very happy with this product!

3.7

Patient Review

6/27/2021

Metrogel-Vaginal for Vaginosis caused by Bacteria

I was prescribed this gel by my gyno to treat recurring bv. I used it once per week for six months as directed, but found that each time I did so, I would end up with a week of really heavy discharge afterwards. It was incredibly inconvenient and messy, so I stopped using it after the six months were up.

2.7

Patient Review

3/12/2016

Metrogel-Vaginal for Vaginosis caused by Bacteria

I have now been using this gel for five days. I experience cramps every night, but they aren't too bad (a four out of ten on the pain scale). The white, wet discharge is really unpleasant though. I hope I don't get a yeast infection after I finish the treatment.

2.7

Patient Review

8/3/2016

Metrogel-Vaginal for Vaginosis caused by Bacteria

I got bacterial vaginosis for the first time post-menopause. My doctor prescribed this gel to use for five nights before bed. It's easy to insert and didn't cause too much leaking when I wake in night time to go to bathroom, but one month later I got BV again. The second time my doctor prescribed this for me again, but it caused inflammation of my internal vaginal tissues, so she told me to stop it after day three. Will not use again.

1

Patient Review

10/6/2019

Metrogel-Vaginal for Vaginosis caused by Bacteria

The cramps, anxiety, and depression I felt after taking this medication were absolutely unbearable. I ended up having to take a different medication (clindimyicin) and it worked much better.

1

Patient Review

6/21/2020

Metrogel-Vaginal for Vaginosis caused by Bacteria

I unfortunately had an allergic reaction in the form of urticaria.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about metrogel-vaginal

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Metrogel VAG gel used for?

"This drugs is used to treat bacterial infections in the vagina. It works by stopping the growth of the bacteria."

Answered by AI

How long does it take for Metrogel to work for BV?

"Cigna Health states that most BV treatments will get rid of symptoms within two to three days, but it is recommended that you finish the treatment for BV within seven days."

Answered by AI

What are the side effects of Metrogel?

"If you experience any negative effects after taking this medication, such as a burning feeling, skin irritation, dryness, redness, metallic taste, nausea, or headache, tell your doctor or pharmacist right away."

Answered by AI

How do I use Metrogel for BV?

"If you are an adult, insert one 500 milligram tablet high into your vagina once a day in the evening for 10 or 20 days. If you are a child, your doctor will determine how much of the medicine you should use and how often you should use it."

Answered by AI

Clinical Trials for Metrogel-Vaginal

Image of University of Texas Health Science Center at San Antonio (Dental School) in San Antonio, United States.

Dexamethasone for Postoperative Pain

18+
All Sexes
San Antonio, TX

Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation. The researchers want to learn if taking dexamethasone by mouth works similarly to receiving dexamethasone through the participant's vein (intravenous, or IV) in reducing short-term pain, swelling, and pain medication after periodontal (gum) flap surgery. The periodontal evaluation, treatment planning, IV sedation, gum surgery, sutures, and usual postoperative care are part of standard care and would be done even if a participant does not join the study. After joining the study, participants will be randomly assigned to the order in which they receive dexamethasone. At one surgery, participants will receive IV dexamethasone plus oral placebo (an inactive substance that looks the same but does not contain dexamethasone). At the next surgery, participants will receive oral dexamethasone plus IV placebo. As part of the study, participants will be asked to record your pain, swelling and any other medication use.

Phase 1 & 2
Waitlist Available

University of Texas Health Science Center at San Antonio (Dental School)

Mostafa Shehabeldin, DDS, MS, PhD

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Image of Cedars-Sinai Medical Center in Los Angeles, United States.

Mobile Mindfulness for Psychological Distress in Critical Illness

18+
All Sexes
Los Angeles, CA

Serious acute heart and lung illnesses like heart failure, severe COVID, and sepsis often leave survivors struggling not only physically, but also with lasting depression, anxiety, and stress. These problems that are hard to treat because access to mental health care is often limited. To help address this, the researchers created Lift, a fully automated mindfulness program designed with patient input and delivered through a mobile app. The investigators now plan a large, multi-site study to test whether Lift improves mental health and quality of life over six months compared to a critical illness education program called Enlighten Recovery. Overall the goal is to make an easy-to-use, widely accessible program available to people across the U.S., including those who speak Spanish.

Waitlist Available
Has No Placebo

Cedars-Sinai Medical Center (+2 Sites)

Christopher Cox, MD, MHA, MPH

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Image of Boise VA Medical Center in Boise, United States.

Pharmacist-Led E-Consults for Lung Health in HIV

18+
All Sexes
Boise, ID

People with HIV (PWH) continue to experience elevated risk of community-acquired pneumonia despite effective antiretroviral therapy. Pneumonia contributes to hospitalization, respiratory failure, cardiovascular complications, long-term decline in lung function, and mortality. Several modifiable factors increase this risk, including active smoking, inadequate receipt of respiratory vaccinations, and inappropriate or prolonged use of inhaled corticosteroids (ICS) or proton-pump inhibitors (PPIs). OPTIMIZE Lung-HIV is a multicenter, patient-level randomized controlled hybrid Type 1 effectiveness-implementation trial evaluating whether a proactive, pharmacist-led E-consult intervention can improve evidence-based pulmonary pharmacotherapy for PWH. Pharmacists will review electronic health records, generate tailored recommendations, and pre-enter orders related to smoking cessation pharmacotherapy, vaccinations, and deprescribing of ICS or PPIs. Providers may enact or modify recommendations as clinically appropriate. The trial will assess the proportion of recommendations enacted within 3 months (primary outcome) and at 12 months (maintenance) and will use mixed methods guided by CFIR and RE-AIM to evaluate adoption, feasibility, acceptability, and implementation barriers and facilitators.

Waitlist Available
Has No Placebo

Boise VA Medical Center (+2 Sites)

Kristina A. Crothers, MD

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