Thiamine for Bacterial Blood Infection
(THRIVE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
To determine if the addition of thiamine to standard-of-care treatment will improve neurodevelopmental outcomes for infants with meningitis or bacteremia
Are You a Good Fit for This Trial?
This trial is for infants who have been diagnosed with meningitis or serious bacterial blood infections. It focuses on babies in early life who are receiving standard medical care for these conditions.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Thiamine Hydrochloride
Trial Overview
The study is testing whether giving thiamine (vitamin B1) along with usual treatment helps improve brain development and recovery compared to a placebo. Infants are randomly assigned to receive either thiamine or a placebo.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participant will receive IV thiamine in addition to standard of care treatment
Participant will receive placebo (IV saline solution) in addition to standard-of-care treatment.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Milton S. Hershey Medical Center
Lead Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator
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