Ibuprofen

Insomnia, Catarrh, Chronic Pain + 33 more

Treatment

13 FDA approvals

20 Active Studies for Ibuprofen

What is Ibuprofen

Ibuprofen

The Generic name of this drug

Treatment Summary

Ibuprofen is a medication used to reduce inflammation and pain. It is a type of non-steroidal anti-inflammatory drug (NSAID) and was first developed in 1960 as an alternative to aspirin. Ibuprofen was patented in 1961 and was first released to treat rheumatoid arthritis in the UK in 1969 and the US in 1974. It is available over-the-counter in the form of a racemic mixture, meaning it contains both the R- and S-enantiomers. The S-enantiomer is believed to be more effective than the R-enantiomer in treating pain and inflammation

Motrin

is the brand name

Ibuprofen Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Motrin

Ibuprofen

1974

2460

Approved as Treatment by the FDA

Ibuprofen, also called Motrin, is approved by the FDA for 13 uses including Rheumatoid Arthritis and Dysmenorrhea .

Rheumatoid Arthritis

Used to treat Rheumatoid Arthritis in combination with Famotidine

Dysmenorrhea

Stomach Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Pain, Acute

Used to treat Pain, Acute in combination with Oxycodone

Osteoarthritis

Used to treat Osteoarthritis (OA) in combination with Famotidine

Gastric Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Osteoarthritis (OA)

Used to treat Osteoarthritis (OA) in combination with Famotidine

Acute Pain

Used to treat Pain, Acute in combination with Oxycodone

Mild pain

Migraine

Fever

Headache

Menstrual Distress (Dysmenorrhea)

Effectiveness

How Ibuprofen Affects Patients

Ibuprofen is used to manage pain, fever, and inflammation. It works by blocking the production of prostanoids, which are substances involved in inflammation. Ibuprofen can also help with dental procedures, menstrual pain, and migraines. It may also reduce neurodegeneration and help with Parkinson's Disease and breast cancer.

How Ibuprofen works in the body

Ibuprofen works by blocking an enzyme called cyclooxygenase. This enzyme helps create substances called prostaglandins, which cause pain and fever. Ibuprofen stops the production of prostaglandins, which reduces inflammation, pain, fever, and swelling. However, blocking this enzyme can also lead to side effects like stomach ulcers.

When to interrupt dosage

The recommended dose of Ibuprofen is reliant upon the identified condition, including smooth muscle relaxation prior to radiological procedures, Catarrh and Pain relief. The quantity of dosage differs, according to the technique of delivery (e.g. Kit - Oral; Topical or Tablet) featured in the table below.

Condition

Dosage

Administration

Chronic Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Migraine

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Migraine

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Insomnia

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Catarrh

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Pain relief

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Pericarditis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Fever

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Arthritis, Gouty

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Migraine Disorders

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Muscle Spasticity

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Rheumatoid Arthritis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Stomach Ulcer

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Cystic Fibrosis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Dysmenorrhea

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Muscle Relaxation

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Osteoarthritis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral; Topical, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Gel, Solution / drops - Oral, Solution / drops

Warnings

Ibuprofen Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Ibuprofen.

Common Ibuprofen Drug Interactions

Drug Name

Risk Level

Description

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Ibuprofen.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Ibuprofen.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Ibuprofen.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Ibuprofen.

Fluorouracil

Major

The metabolism of Fluorouracil can be decreased when combined with Ibuprofen.

Ibuprofen Toxicity & Overdose Risk

Consuming more than 99mg/kg of ibuprofen can lead to abdominal pain, nausea, vomiting, fatigue, dizziness, vertigo, drowsiness, insomnia, headache, fainting, ringing in the ears, depression of the central nervous system, seizures, and difficulty breathing. In very rare cases, it can also cause metabolic acidosis, abnormal liver function, high potassium levels, kidney failure, and coma. The reported lethal dose of ibuprofen is 636mg/kg in rats, 740mg/kg in mice, and 495mg/kg in guinea pigs.

Ibuprofen Novel Uses: Which Conditions Have a Clinical Trial Featuring Ibuprofen?

At present, there are 531 active trials examining the potential of Ibuprofen in managing Rheumatoid Arthritis, Chronic Pain and Migraine Symptoms.

Condition

Clinical Trials

Trial Phases

Migraine

16 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Chronic Pain

128 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1

Rheumatoid Arthritis

63 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Muscle Relaxation

0 Actively Recruiting

Migraine

52 Actively Recruiting

Phase 4, Phase 1, Not Applicable, Phase 3, Phase 2, Early Phase 1

Juvenile arthritis

7 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Aquaporin 2

3 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Premature Birth

28 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1

Pain

0 Actively Recruiting

Influenza

0 Actively Recruiting

Acute Pain

2 Actively Recruiting

Not Applicable, Phase 1

Primary Dysmenorrhoea

2 Actively Recruiting

Not Applicable

Nasal Congestion

0 Actively Recruiting

Catarrh

1 Actively Recruiting

Not Applicable

Pericarditis

3 Actively Recruiting

Phase 2, Phase 3

Arthritis, Gouty

0 Actively Recruiting

Insomnia

0 Actively Recruiting

Pain

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Pain

0 Actively Recruiting

Patient Q&A Section about ibuprofen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should not take ibuprofen?

"If you have severe heart failure, severe kidney failure or severe liver failure, are trying to get pregnant, have high blood pressure that's not under control, have heart disease or mild to moderate heart failure, or have ever had a stroke, you may not be able to use Invokana."

Answered by AI

What is ibuprofen used for?

"Ibuprofen can be bought without a prescription and is a type of painkiller known as an NSAID. It can be used to relieve mild to moderate pain, such as toothache, migraine, and period pain."

Answered by AI

How is ibuprofen harmful?

"NSAIDs may cause ulcers, bleeding, or holes in the stomach or intestine, which can develop at any time during treatment and may happen without warning symptoms. This can lead to death."

Answered by AI

What is better Tylenol or ibuprofen?

"Acetaminophen is most effective for fever, aches, and pains, but is less effective for pain caused by inflammation. Ibuprofen is more effective for pain caused by inflammation, such as menstrual cramps and arthritis."

Answered by AI

Clinical Trials for Ibuprofen

Image of Ohio State University in Columbus, United States.

Alcohol for Opioid Use Disorder

21 - 65
All Sexes
Columbus, OH

The goal of this clinical trial is to examine whether individuals with co-occurring opioid use disorder and alcohol use (OUD+ALC) experience heightened pain sensitivity, pain-related negative affect, and greater alcohol reinforcement compared with alcohol-only (ALC) or opioid-only (OUD-ALC) users. The main questions it aims to answer are: * Aim 1. Do individuals with OUD+ALC experience increased pain and pain-related negative affect during periods of sobriety relative to mono-users of alcohol (ALC only) and opioids (OUD-ALC)? * Aim 2. Do individuals with OUD+ALC experience greater alcohol-induced analgesia and alcohol reinforcement compared with mono-users of alcohol (ALC only) and opioids (OUD-ALC)? Participants will: * Complete a screening session * Complete one lab session including a comprehensive assessment battery involving multimodal assessments of pain during sobriety * Complete two experimental lab sessions that will include intravenous (IV) administration of either 80mg% alcohol or placebo (saline), order counterbalanced, to measure alcohol's acute effects on pain and pain-related negative affect

Phase < 1
Waitlist Available

Ohio State University

Image of Northwell health physician partners in Bay Shore, United States.

Lidocaine Injection vs Saline for Pain Management

18+
Female
Bay Shore, NY

We are doing this study to find the best way to manage pain during a procedure called urethral bulking. This procedure treats urine leakage that happens with coughing, laughing, sneezing, or physical activity. It works by injecting a gel-like substance around the urethra (the tube that urine comes out of) to help it stay closed when it should. We use a numbing gel (called lidocaine jelly) inside the urethra to help with pain during the procedure. In this study, we will also be administering lidocaine (numbing medication) injected around the urethra or a saline placebo (medical grade saltwater) injection, which has no numbing effect. A placebo is something that looks like a real treatment but doesn't have any medical effect. Both the lidocaine and the saline would be injected around the urethra using a small needle, and we'll compare how well they work at reducing pain.

Phase 4
Recruiting

Northwell health physician partners (+2 Sites)

Image of Endeavor Health/NorthShore in Skokie, United States.

Tranexamic Acid for Anterior Cruciate Ligament Injury

14 - 25
All Sexes
Skokie, IL

The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years. All participants receive standard intravenous TXA during surgery. The main questions it aims to answer are: * Does oral TXA lower knee pain at 2 weeks after surgery? * Does oral TXA reduce the amount of opioid pain medicine used in the first 2 weeks? * Does oral TXA improve knee range of motion at 2 weeks? Researchers will compare oral TXA to a placebo (a look-alike capsule with no active drug) to see if oral TXA improves pain, opioid use, motion, strength, knee function, and return to sport. Participants will: * Take 3 capsules (oral TXA or placebo) once a day for the first 8 days after surgery (day of surgery through day 7) * Keep a home diary for 2 weeks recording pain scores, opioid pills taken and any side effects * Return for study visits at 2 weeks, 6 weeks, 12 weeks, 6 months, 9 months and 1 year for pain, motion, strength and function testing * Complete a survey at 2 years

Phase 3
Waitlist Available

Endeavor Health/NorthShore (+5 Sites)

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Image of Northwestern Medicine Rheumatology in Chicago, United States.

Patient-Reported Outcomes Dashboard for Inflammatory Arthritis

18+
All Sexes
Chicago, IL

The goal of this clinical trial is to learn whether showing patient-reported symptoms and personal treatment goals to rheumatology clinicians on a dashboard in the electronic health record improves shared decision-making for adults with rheumatoid arthritis or psoriatic arthritis. The main questions it aims to answer are: * Do patients whose clinicians use the dashboard report more shared decision-making during their rheumatology visits than patients who receive usual care? * Do patients in the dashboard group report greater progress toward their personal goals and more confidence in managing their symptoms after 6 months? Researchers will compare the dashboard group to a usual care group to see if the dashboard improves shared decision-making, goal attainment, and self-efficacy. Participants will: * Complete a routine symptom questionnaire before their rheumatology visits, as all clinic patients do * Choose personal treatment goals and rate their progress toward those goals 6 months later * Complete short surveys before and after two rheumatology visits about 6 months apart Participants in the dashboard group will also complete questionnaires in the patient portal about pain, fatigue, physical function, sleep, and morning stiffness before each visit. Their answers and goals will be shown to their clinician on a dashboard to guide the conversation during the visit.

Waitlist Available
Has No Placebo

Northwestern Medicine Rheumatology

Image of Hospital for Special Surgery in New York, United States.

Suzetrigine for Pain Management in Total Knee Replacement

18 - 80
All Sexes
New York, NY

Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery. Despite widespread use of multimodal regimens, many patients still rely on opioids, which can cause sedation, nausea, constipation, and long-term dependency. Evaluating suzetrigine in this high-need population may improve recovery trajectories, reduce opioid consumption, and support enhanced recovery protocols. Given the growing surgical volume and the emphasis on opioid-sparing strategies, rigorous investigation of suzetrigine's efficacy in total knee replacement is of high clinical value. In this confirmatory (phase III) trial, patients undergoing primary total knee replacement will be randomized to receive either suzetrigine or placebo for 2 weeks (14 days), with the loading dose administered prior to surgery. The primary outcome is cumulative 48-hour opioid consumption in oral morphine equivalents starting from entry into the post-anesthesia care unit (PACU).

Phase 3
Recruiting

Hospital for Special Surgery

Meghan Kirskey, MD

Image of Texas A&M University-Corpus Christi in Corpus Christi, United States.

Auricular Point Acupressure for Pain Management

18+
All Sexes
Corpus Christi, TX

The goal of this pilot clinical trial is to learn whether auricular point acupressure (APA) can help reduce chronic musculoskeletal pain in adults age 50 and older who are living with HIV. The study will also examine whether APA is feasible, acceptable, and safe for this population. The main questions it aims to answer are: Does APA reduce chronic musculoskeletal pain and improve sleep and quality of life? Is APA feasible, acceptable, and safe for older people living with HIV? Researchers will compare true APA, in which small seeds are taped to specific ear points related to pain, with sham APA, in which seeds are taped to ear points not related to pain. The intervention will last 4 weeks. Participants will: Receive true APA or sham APA for 4 weeks Visit the study site weekly for placement of the ear seeds Press the ear seeds for 3 minutes, 3 times each day Complete daily surveys about pain and pain medication use Use a sleep monitor to track sleep Complete study assessments at the beginning and end of the intervention Complete an exit interview about their experience with APA

Waitlist Available
Senior-friendly

Texas A&M University-Corpus Christi

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Image of M Health Fairview Clinic - Oxboro in Minneapolis, United States.

TENS and Vibration for Procedural Pain

18+
All Sexes
Minneapolis, MN

The E-MOHS Trial is a randomized controlled trial evaluating whether active vibration plus transcutaneous electrical nerve stimulation reduces pain during local anesthetic infiltration in adults undergoing Mohs micrographic surgery or dermatologic excision. Participants will be randomized to active vibration:TENS or sham TENS during the first local anesthetic administration. The primary outcome is patient-reported infiltration pain during active local anesthetic infiltration, measured using the 11-point Numeric Rating Scale. Secondary outcomes include infiltration pain measured using a Visual Analog Scale, perioperative anxiety, participant satisfaction, willingness to reuse the device, operator-rated ease of use and sterile-field compatibility, blinding integrity, and adverse events.

Waitlist Available
Background Therapy Allowed

M Health Fairview Clinic - Oxboro (+3 Sites)

Ian Maher, MD

Image of UPMC Children's Community Pediatrics in Pittsburgh, United States.

Enhanced Telemedicine for Acute Respiratory Tract Infections

6 months - 24 months
All Sexes
Pittsburgh, PA

Young children often receive antibiotics for pediatric acute respiratory tract infections (ARTIs) - common childhood diagnoses like ear infections, strep throat, sinusitis, and colds - but many of these antibiotics are prescribed unnecessarily for viral infections, where antibiotics will not help. Helping families and pediatricians to evaluate children with ARTIs through primary care telemedicine visits using at-home tele-otoscopes vs. at-home eBooks could help reduce unnecessary antibiotic exposure in children. In this clinical trial, the investigators will assess the impact of at-home tele-otoscope vs. eBook enabled primary care telemedicine on antibiotic use, healthcare utilization, and healthcare costs for young children.

Waitlist Available
1 Prior Treatment

UPMC Children's Community Pediatrics (+1 Sites)

Kristin Ray, MD, MS

Image of Theranica Bio-Electronics Inc in Bridgewater, United States.

Remote Electrical Neuromodulation for Migraine

18+
All Sexes
Bridgewater, NJ

Migraine and Fibromyalgia (FM) are chronic pain disorders characterized by altered central pain processing and impaired endogenous pain inhibition. FM presents with widespread musculoskeletal pain, fatigue, sleep disturbance, and cognitive symptoms and is strongly associated with central sensitization. Migraine similarly involves dysfunction of central inhibitory and descending pain modulation, with evidence of abnormal cortical excitability, impaired sensory habituation, and alterations in pain-related evoked potentials. Conditioned Pain Modulation (CPM) is a measure of the body's endogenous pain-inhibitory mechanism, based on the phenomenon whereby the pain evoked by one painful stimulus (the test stimulus) is reduced by the concurrent application of a second, remote nociceptive stimulus (the conditioning stimulus). It is widely regarded as a proxy for the function of descending pain-modulatory pathways. CPM is used as an experimental biomarker of descending pain inhibition across chronic pain conditions, including fibromyalgia and migraine. Studies consistently demonstrate reduced inhibitory responses in both migraine and fibromyalgia compared with healthy controls, indicating a robust deficit in descending pain modulatory systems. Combining a contact heat test stimulus (TS) with a cold pressor conditioning stimulus (CS) is a widely used and validated CPM paradigm. Nerivio, a Remote Electrical Neuromodulation (REN) device, is a non-invasive, non-pharmacological therapy indicated for the acute and preventive treatment of migraine. The REN device is worn on the upper arm and delivers peripheral electrical stimulation to activate CPM-related descending inhibitory pathways and reduce migraine pain. This distal stimulation approach is designed to activate CPM-related circuits by recruiting brainstem pain-regulatory centers and modulating central nociceptive processing. This randomized, double-blind, placebo-controlled trial is designed to assess the effect of a single REN session on CPM and cortical pain processing in adults with migraine or fibromyalgia. Using a standardized CPM induction protocol, the study will evaluate changes in behavioral CPM responses, before, during, and after REN vs. sham stimulation in patients with migraine or fibromyalgia. This study aims to clarify whether REN enhances descending pain inhibition and pain processing in populations with impaired endogenous pain modulation.

Recruiting
Online Trial

Theranica Bio-Electronics Inc

Alit Stark Inbar, PhD

Theranica

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