Oravig

Inflammation, Tinea Pedis, Dermatophytosis + 20 more

Treatment

20 Active Studies for Oravig

What is Oravig

Miconazole

The Generic name of this drug

Treatment Summary

Miconazole is an antifungal medication used to treat yeast infections of the mucous membranes, in both the mouth and vagina. It is available in a variety of prescription and non-prescription forms, such as creams, gels, and tablets. The drug works by inhibiting the activity of a certain enzyme in fungi, which helps stop the spread of the infection. Miconazole has been available since 1974 and is generally well tolerated with low risk of resistance.

SUNMARK MICONAZOLE NITRATE antifungal

is the brand name

image of different drug pills on a surface

Oravig Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

SUNMARK MICONAZOLE NITRATE antifungal

Miconazole

1991

255

Effectiveness

How Oravig Affects Patients

Miconazole is a medicine used to treat fungal infections. It works by blocking a certain enzyme that helps the fungus grow. When applied directly to the skin, it is not absorbed into the body and usually does not cause any side effects. However, people who use miconazole for intravaginal use should not use tampons or rely on contraceptives to prevent pregnancy or infection.

How Oravig works in the body

Miconazole works in several ways to fight fungal infections. It blocks an enzyme that helps create the cell membrane of fungi, making it harder for them to survive. It also makes it harder for fungi to produce energy and survive in the body. Miconazole also causes fungi to produce a molecule called farnesol, which inhibits their ability to form biofilms, which are resistant to antibiotics. Lastly, farnesol stops fungi from pumping out drugs, making them more susceptible to miconazole.

When to interrupt dosage

The suggested measure of Oravig is based on the diagnosed condition, including Gastrointestinal candidiasis, Nail candida and Infection, Mixed. The dosage can be found in the table below and is contingent upon the approach of delivery (e.g. Topical or Aerosol, spray - Topical).

Condition

Dosage

Administration

Arthrodermataceae

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Dermatophytosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Skin candida

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Yeast Infection

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Onychomycosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Cellulitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Intertrigo

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Tinea Versicolor

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Kerion Celsi

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Dermatitis, Seborrheic

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Tinea Cruris

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Tinea

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Dermatitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

cutaneous candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Oropharyngeal Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Ringworm

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Inflammation

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Tinea Pedis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Tincture, Tincture - Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Cream - Vaginal, Vaginal, Aerosol, powder - Topical, Aerosol, powder, Suppository, Suppository - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Cream; Insert, Cream; Suppository, Topical; Vaginal, Spray - Topical, Spray, Kit - Vaginal, Tablet, Tablet - Buccal, Buccal, Insert, Insert - Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Kit - Topical, Paste, Paste - Topical

Warnings

Oravig has two forbiddances and should not be used while encountering any of the conditions mentioned in the following table.

Oravig Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Miconazole may interact with Pulse Frequency

There are 20 known major drug interactions with Oravig.

Common Oravig Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Miconazole.

Abrocitinib

Major

The metabolism of Abrocitinib can be decreased when combined with Miconazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Miconazole.

Acetylsalicylic acid

Major

The metabolism of Acetylsalicylic acid can be decreased when combined with Miconazole.

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Miconazole.

Oravig Toxicity & Overdose Risk

Taking too much miconazole can lead to serious side effects such as headaches, skin irritation, diarrhea, nausea, vomiting, abdominal pain, and bad taste in the mouth. It is recommended that those who overdose on miconazole receive appropriate medical care and supportive measures. The lethal dose of miconazole for rats is 500mg/kg.

image of a doctor in a lab doing drug, clinical research

Oravig Novel Uses: Which Conditions Have a Clinical Trial Featuring Oravig?

203 active trials are underway to assess the potential of Oravig to alleviate Dermatophytosis, reduce Inflammation and abate Excessive Sweating and Body Odor.

Condition

Clinical Trials

Trial Phases

Inflammation

61 Actively Recruiting

Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 1

Yeast Infection

0 Actively Recruiting

Onychomycosis

0 Actively Recruiting

Acne Vulgaris

5 Actively Recruiting

Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3

Candidiasis

0 Actively Recruiting

Dermatitis, Seborrheic

0 Actively Recruiting

Dermatophytosis

0 Actively Recruiting

cutaneous candidiasis

0 Actively Recruiting

Cellulitis

0 Actively Recruiting

Tinea Versicolor

0 Actively Recruiting

Skin candida

0 Actively Recruiting

Tinea Pedis

0 Actively Recruiting

Arthrodermataceae

0 Actively Recruiting

Kerion Celsi

0 Actively Recruiting

Candidiasis, Vulvovaginal

0 Actively Recruiting

Tinea Cruris

0 Actively Recruiting

Tinea

0 Actively Recruiting

Intertrigo

0 Actively Recruiting

Oropharyngeal Candidiasis

0 Actively Recruiting

Ringworm

0 Actively Recruiting

Oravig Reviews: What are patients saying about Oravig?

4

Patient Review

6/16/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

I've had to deal with a lot of fungal infections due to my inhalers, and I've tried nystatin and dyflucan multiple times. They just don't work for me. This pill is expensive, but it does the job. It takes some time getting used to, but I feel that it's worth the price if it works.

2.7

Patient Review

11/16/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

I've only been using this pill for a few days, so it's hard to judge its effectiveness yet. It's not too comfortable having it in my upper lip, but I'm getting used to it. It's also pretty pricey if you don't have insurance.

1.3

Patient Review

9/15/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

This treatment was really bad for me. I had terrible dry mouth and started seeing hair in front of my eyes. I was so tired and exhausted all the time. I quit immediately and threw the bottle away. There has to be some other drug that will kill thrush. Fluconozole hasn't touched it after 6 rounds. :(

1

Patient Review

1/12/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

I really didn't enjoy the sensation of something in my mouth for such a long period of time. It was difficult to keep in place and seemed to get bigger as time went on. I would not use this product again or recommend it to anyone else.

1

Patient Review

1/30/2013

Oravig for Candidiasis Fungal Infection of the Oropharynx

I'm on my second 14-day supply of this drug and it still hasn't cleared up my thrush. Not to mention, it's extremely expensive. I wouldn't recommend this to anyone.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about oravig

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is oravig available?

"Although there are no therapeutically equivalent versions of Oravig currently available in the United States, it's important to be aware that there are online pharmacies which may attempt to sell illegal generic versions of the medication. These medications may be counterfeit and could potentially be unsafe."

Answered by AI

How do you take oravig?

"To use the Oravig buccal tablet, place the rounded side of the tablet against your gum and close your mouth. Press your finger gently against the side of your cheek for 30 seconds to make sure the tablet stays in place. Do not chew or swallow the tablet. Leave it in place until the next morning."

Answered by AI

What is oravig used for?

"Oral thrush is a condition that can be treated using Oravig (miconazole), an antifungal tablet that is dissolved in the patient's cheek. Oravig works by killing the fungus that causes yeast infections, by damaging its protective outer layer."

Answered by AI

What class of medication is oravig?

"Oravig is a prescription medication used to treat symptoms of Oropharyngeal Candidiasis. Oravig may be used alone or in combination with other medications. Oravig belongs to a class of drugs called "Antifungals, Other.""

Answered by AI

Clinical Trials for Oravig

Image of Texas Tech University Health Sciences Center/ University Medical Center Lubbock in Lubbock, United States.

PSP Monitoring for Sepsis in Burns

18 - 89
All Sexes
Lubbock, TX

The goal of this clinical trial is to learn if using pancreatic stone protein (PSP) test results helps doctors find and treat sepsis earlier in adults with serious burn injuries. The study will also look at whether using PSP is safe and practical in the burn intensive care unit. The main questions it aims to answer are: * Does seeing PSP test results help doctors start the right antibiotics sooner? * Does using PSP reduce unnecessary antibiotic use? * Does using PSP improve recovery and other health outcomes? Researchers will compare two groups of patients. One group will receive standard care, and their PSP test results will be hidden from their care team. The other group will receive standard care, but their care team will be able to see the PSP test results and use them to help make treatment decisions. Participants will: * Be randomly assigned to one of the two study groups. * Have a small blood sample taken within 24 hours after being admitted to the burn ICU and then once each weekday while they are in the ICU. * Receive the usual care for burn injuries and sepsis throughout the study.

Waitlist Available
Has No Placebo

Texas Tech University Health Sciences Center/ University Medical Center Lubbock

Brian Schneider, MD

Abionic SA

Image of Nicholas Institute of Sports Medicine & Athletic Trauma (NISMAT) in New York, United States.

Fruit Juice for Inflammation

18 - 65
All Sexes
New York, NY

Dietary patterns and physical inactivity common in Western societies have been associated with chronic low-grade inflammation and an increased risk of non-communicable health conditions. Fruits and vegetables contain polyphenols and other bioactive compounds that may have antioxidant and anti-inflammatory properties and may influence inflammatory biomarkers. This study will evaluate the effects of increased consumption of a fruit juice on inflammatory biomarkers and exercise capacity in adults with mildly elevated inflammation. Approximately 40 participants will be randomly assigned to consume one of two fruit juice interventions daily for approximately 2 weeks. Changes in C-reactive protein (CRP) and exercise capacity, assessed using a 6-minute walk test, will be evaluated before and after the intervention and compared between the two groups.

Recruiting
Has No Placebo

Nicholas Institute of Sports Medicine & Athletic Trauma (NISMAT)

Christopher Tanayan, MD

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Image of London Regional Health Science Centre in London, Canada.

Genistein for Cardiovascular Health in HIV

18 - 80
All Sexes
London, Canada

People living with HIV (PLHIV) live longer because of modern HIV medicines, but even with these treatments, their bodies are more inflamed. Long term inflammation increases the risk of heart disease, chronic pain, lung disease, dementia, arthritis, and other infections. Because some anti-inflammatory medicines can cause serious side effects, interact with HIV drugs, or be costly, safer and more affordable treatment options are needed. Genistein is a natural compound found in soy foods. It is considered safe and has been shown to reduce inflammation and improve blood vessel health. This study will test whether genistein can lower inflammation in the blood, improve blood vessel health, and reduce pain in PLHIV.

Phase 1 & 2
Waitlist Available

London Regional Health Science Centre

Mark JK Chandy, MD PhD

Greenstone Biosciences, Inc.

Image of University of Utah in Salt Lake City, United States.

Metformin for Muscle Weakness

18+
All Sexes
Salt Lake City, UT

The purpose of this research study is to determine if Metformin taken after anterior cruciate ligament reconstruction (ACLR) surgery can decrease muscle fibrosis, cellular senescence and improve leg strength. ACL injury and surgery increase muscle collagen content and inflammation which slows the recovery of muscle and function and ultimately impacts the quality of life. Individuals enrolled in the study will be randomized to receive metformin (or placebo) for 4 months after surgery. The investigators will measure muscle strength and inflammatory markers in muscle biopsy samples after the intervention period. Investigators will also follow up with participants 8 months later to determine the lasting effects of the intervention.

Phase < 1
Waitlist Available

University of Utah

Micah Drummond

Image of Reichwald Health Sciences Centre in Kelowna, Canada.

Broccoli Sprout Extract + Exercise for Inflammation

19 - 35
All Sexes
Kelowna, Canada

The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period. One of the interventions consists of 4 days of daily supplementation with the commercially available broccoli sprout extract capsules (BrocElite). Another intervention will consist of 4 days of daily supervised treadmill running. The exercise protocol consists of 4 minutes of high-intensity running running followed by a 3 minute recovery period, repeated for a total of 4 repetitions. The last intervention combines the above two and consists of 4 days of daily supplementation and daily supervised exercise training. Before and after each intervention, basic anthropometrics (weight, heart rate, and blood pressure) will be recorded, and a venous blood sample will be collected. Blood samples will be analyzed for metabolic and inflammatory markers. Participants will be asked to refrain from structured exercise, alcohol consumption, and broccoli consumption during each of the experimental periods. Before any testing, willing participants will provide informed consent, and fill out a few demographic, and lifestyle questionnaires. The study will be conducted at the University of British Columbia in Kelowna, BC, Canada.

Recruiting
Has No Placebo

Reichwald Health Sciences Centre

Image of Vanderbilt University Medical Center in Nashville, United States.

2-HOBA for Salt Sensitivity of Blood Pressure

18+
All Sexes
Nashville, TN

Hypertension is the leading cause of preventable deaths globally, driven by complications such as myocardial infarction, stroke, heart failure, and kidney disease. Recent updates in hypertension classification by the American Heart Association (AHA) place nearly half of the U.S. population in the hypertensive category. Excess dietary salt is a major risk factor for hypertension, with 50% of hypertensive individuals exhibiting salt-sensitivity of blood pressure (SSBP). SSBP is an independent predictor of cardiovascular events and death. While kidney mechanisms in salt-sensing have been extensively studied, emerging evidence suggests that immune cells can also sense sodium (Na+). This trial hypothesizes that myeloid cell-derived isolevuglandins (IsoLGs) drive endothelial dysfunction, perpetuating the salt-sensitive phenotype. Preliminary data indicate that targeting IsoLGs with the IsoLG scavenger 2-hydroxybenzylamine (2-HOBA) may interrupt this immune-vascular axis, reducing salt sensitivity and associated cardiovascular risks. This phase 2 clinical trial aims to investigate the role of 2-HOBA in modulating immune cell function within blood vessels in hypertensive patients. The study will explore the impact of immunity on salt sensitivity and assess 2-HOBA's potential to reduce endothelial dysfunction, improve immune cell activation, and alleviate SSBP.

Phase 2
Waitlist Available

Vanderbilt University Medical Center

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Image of University of Oklahoma Health Campus in Oklahoma City, United States.

Disulfiram for Rheumatoid Arthritis

18 - 75
All Sexes
Oklahoma City, OK

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation. Obesity is common among individuals with RA and is associated with increased disease activity, reduced treatment response, and worse functional outcomes. Inflammation in adipose tissue, driven in part by activation of the NLRP3 inflammasome and downstream gasdermin D (GSDMD)-mediated pathways, may contribute to systemic inflammation and RA disease severity. Disulfiram (DSF), an FDA-approved medication for alcohol use disorder, has recently been identified as an inhibitor of GSDMD-mediated inflammatory signaling and pyroptosis. Preclinical studies suggest that DSF reduces inflammasome activation, inflammatory cytokine release, and metabolic dysfunction. This study is a 12-week, randomized, double-blind, placebo-controlled pilot trial designed to evaluate the safety, tolerability, and preliminary efficacy of DSF in overweight and obese adults with active RA despite stable disease-modifying antirheumatic drug (DMARD) therapy. Participants will be randomized to receive either DSF (250 mg daily) or placebo. The primary objective is to assess safety and tolerability. Secondary and exploratory objectives include evaluating the effects of DSF on systemic inflammation, RA disease activity, metabolic parameters, and adipose tissue inflammasome activation. Findings from this study will inform the feasibility and design of larger clinical trials targeting GSDMD-mediated inflammation in RA.

Phase 2
Waitlist Available

University of Oklahoma Health Campus

Beatriz Y Hanaoka, MD, MSc

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