Monistat

Inflammation, Tinea Pedis, Dermatophytosis + 20 more

Treatment

20 Active Studies for Monistat

What is Monistat

Miconazole

The Generic name of this drug

Treatment Summary

Miconazole is an antifungal medication used to treat fungal infections, like yeast infections. It is available as a variety of creams, gels, tablets, and suppositories. Miconazole was first approved by the FDA in 1974 and is still widely used today. Although it has been around for a long time, it has not developed much resistance among the organisms it fights.

SUNMARK MICONAZOLE NITRATE antifungal

is the brand name

image of different drug pills on a surface

Monistat Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

SUNMARK MICONAZOLE NITRATE antifungal

Miconazole

1991

255

Effectiveness

How Monistat Affects Patients

Miconazole is an antifungal medication that works by preventing the growth of certain types of fungi. Since it is usually applied to the skin, the majority of the side effects are related to allergies. For intravaginal (inside the vagina) use, patients should not use tampons at the same time and should use another form of contraception to prevent pregnancy and sexually transmitted infections.

How Monistat works in the body

Miconazole is an antifungal medication used to treat Candida infections. It works in three main ways. First, it stops the Candida cells from producing a certain type of molecule called ergosterol, which is important for the cell's structure and function. Second, it increases the production of substances called reactive oxygen species (ROS) inside the cells, which can lead to cell death. Third, it causes Candida cells to produce more of a molecule called farnesol, which prevents them from forming biofilms that are resistant to antibiotics. It also blocks certain "pumps" inside Candida cells that

When to interrupt dosage

The recommended dosage of Monistat is contingent upon the diagnosed affliction, such as Gastrointestinal candidiasis, Nail candida and Infection, Mixed. The amount of dosage can be found in the table below, reliant upon the mode of delivery (e.g. Topical or Aerosol, spray - Topical).

Condition

Dosage

Administration

Arthrodermataceae

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Tinea Versicolor

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Kerion Celsi

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Dermatitis, Seborrheic

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Ringworm

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Dermatophytosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Skin candida

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Onychomycosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Cellulitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Yeast Infection

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

cutaneous candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Oropharyngeal Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Tinea Cruris

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Dermatitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Intertrigo

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Tinea

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Inflammation

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Tinea Pedis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, powder - Topical, Aerosol, powder, Aerosol, spray - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Kit - Topical; Vaginal, Buccal, Aerosol, spray, Tablet, Tablet - Buccal, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Cream; Insert - Topical; Vaginal, Cream; Suppository - Topical; Vaginal, Topical; Vaginal, Cream; Insert, Cream; Suppository, Lotion, Lotion - Topical, Paste, Paste - Topical, Kit - Topical

Warnings

Monistat Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Miconazole may interact with Pulse Frequency

There are 20 known major drug interactions with Monistat.

Common Monistat Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Miconazole.

Abrocitinib

Major

The metabolism of Abrocitinib can be decreased when combined with Miconazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Miconazole.

Acetylsalicylic acid

Major

The metabolism of Acetylsalicylic acid can be decreased when combined with Miconazole.

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Miconazole.

Monistat Toxicity & Overdose Risk

Taking too much miconazole may cause headaches, skin irritation, diarrhea, nausea, vomiting, stomach pain, and a change in taste. These symptoms can be managed with supportive care. The lowest toxic dose of miconazole in rats has been found to be 500mg/kg.

image of a doctor in a lab doing drug, clinical research

Monistat Novel Uses: Which Conditions Have a Clinical Trial Featuring Monistat?

203 active clinical trials are examining the potential of Monistat to reduce Dermatophytosis, Inflammation and Abnormal Sweating and Body Odor.

Condition

Clinical Trials

Trial Phases

Inflammation

61 Actively Recruiting

Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 1

Yeast Infection

0 Actively Recruiting

Onychomycosis

0 Actively Recruiting

Acne Vulgaris

5 Actively Recruiting

Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3

Candidiasis

0 Actively Recruiting

Dermatitis, Seborrheic

0 Actively Recruiting

Dermatophytosis

0 Actively Recruiting

cutaneous candidiasis

0 Actively Recruiting

Cellulitis

0 Actively Recruiting

Tinea Versicolor

0 Actively Recruiting

Skin candida

0 Actively Recruiting

Tinea Pedis

0 Actively Recruiting

Arthrodermataceae

0 Actively Recruiting

Kerion Celsi

0 Actively Recruiting

Candidiasis, Vulvovaginal

0 Actively Recruiting

Tinea Cruris

0 Actively Recruiting

Tinea

0 Actively Recruiting

Intertrigo

0 Actively Recruiting

Oropharyngeal Candidiasis

0 Actively Recruiting

Ringworm

0 Actively Recruiting

Monistat Reviews: What are patients saying about Monistat?

5

Patient Review

4/9/2011

Monistat for Yeast Infection of Vagina and Vulva

This treatment worked better than anything else I've ever used.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about monistat

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does MONISTAT take to work?

"You can expect MONISTAT® products to take up to 7 days to fully cure a yeast infection."

Answered by AI

What do you use MONISTAT for?

"This medication is used to treat vaginal yeast infections by reducing burning, itching, and discharge. It is an azole antifungal that works by stopping the growth of yeast that causes the infection."

Answered by AI

Does MONISTAT clear all yeast infections?

"If this is your first time experiencing a yeast infection, you should consult with a healthcare professional before using this product. The symptoms of a yeast infection can be similar to other conditions such as bacterial vaginosis or sexually transmitted infections. Monistat is only effective in treating fungal infections and not any other type of condition."

Answered by AI

What does MONISTAT do inside of you?

"The active ingredient in MONISTAT® products fights yeast and is applied inside the vagina to treat and cure the yeast infection. Most MONISTAT® products also come with external itch relief cream for relief of symptoms."

Answered by AI

Clinical Trials for Monistat

Image of Texas Tech University Health Sciences Center/ University Medical Center Lubbock in Lubbock, United States.

PSP Monitoring for Sepsis in Burns

18 - 89
All Sexes
Lubbock, TX

The goal of this clinical trial is to learn if using pancreatic stone protein (PSP) test results helps doctors find and treat sepsis earlier in adults with serious burn injuries. The study will also look at whether using PSP is safe and practical in the burn intensive care unit. The main questions it aims to answer are: * Does seeing PSP test results help doctors start the right antibiotics sooner? * Does using PSP reduce unnecessary antibiotic use? * Does using PSP improve recovery and other health outcomes? Researchers will compare two groups of patients. One group will receive standard care, and their PSP test results will be hidden from their care team. The other group will receive standard care, but their care team will be able to see the PSP test results and use them to help make treatment decisions. Participants will: * Be randomly assigned to one of the two study groups. * Have a small blood sample taken within 24 hours after being admitted to the burn ICU and then once each weekday while they are in the ICU. * Receive the usual care for burn injuries and sepsis throughout the study.

Waitlist Available
Has No Placebo

Texas Tech University Health Sciences Center/ University Medical Center Lubbock

Brian Schneider, MD

Abionic SA

Image of Nicholas Institute of Sports Medicine & Athletic Trauma (NISMAT) in New York, United States.

Fruit Juice for Inflammation

18 - 65
All Sexes
New York, NY

Dietary patterns and physical inactivity common in Western societies have been associated with chronic low-grade inflammation and an increased risk of non-communicable health conditions. Fruits and vegetables contain polyphenols and other bioactive compounds that may have antioxidant and anti-inflammatory properties and may influence inflammatory biomarkers. This study will evaluate the effects of increased consumption of a fruit juice on inflammatory biomarkers and exercise capacity in adults with mildly elevated inflammation. Approximately 40 participants will be randomly assigned to consume one of two fruit juice interventions daily for approximately 2 weeks. Changes in C-reactive protein (CRP) and exercise capacity, assessed using a 6-minute walk test, will be evaluated before and after the intervention and compared between the two groups.

Recruiting
Has No Placebo

Nicholas Institute of Sports Medicine & Athletic Trauma (NISMAT)

Christopher Tanayan, MD

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Image of London Regional Health Science Centre in London, Canada.

Genistein for Cardiovascular Health in HIV

18 - 80
All Sexes
London, Canada

People living with HIV (PLHIV) live longer because of modern HIV medicines, but even with these treatments, their bodies are more inflamed. Long term inflammation increases the risk of heart disease, chronic pain, lung disease, dementia, arthritis, and other infections. Because some anti-inflammatory medicines can cause serious side effects, interact with HIV drugs, or be costly, safer and more affordable treatment options are needed. Genistein is a natural compound found in soy foods. It is considered safe and has been shown to reduce inflammation and improve blood vessel health. This study will test whether genistein can lower inflammation in the blood, improve blood vessel health, and reduce pain in PLHIV.

Phase 1 & 2
Waitlist Available

London Regional Health Science Centre

Mark JK Chandy, MD PhD

Greenstone Biosciences, Inc.

Image of University of Utah in Salt Lake City, United States.

Metformin for Muscle Weakness

18+
All Sexes
Salt Lake City, UT

The purpose of this research study is to determine if Metformin taken after anterior cruciate ligament reconstruction (ACLR) surgery can decrease muscle fibrosis, cellular senescence and improve leg strength. ACL injury and surgery increase muscle collagen content and inflammation which slows the recovery of muscle and function and ultimately impacts the quality of life. Individuals enrolled in the study will be randomized to receive metformin (or placebo) for 4 months after surgery. The investigators will measure muscle strength and inflammatory markers in muscle biopsy samples after the intervention period. Investigators will also follow up with participants 8 months later to determine the lasting effects of the intervention.

Phase < 1
Waitlist Available

University of Utah

Micah Drummond

Image of Reichwald Health Sciences Centre in Kelowna, Canada.

Broccoli Sprout Extract + Exercise for Inflammation

19 - 35
All Sexes
Kelowna, Canada

The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period. One of the interventions consists of 4 days of daily supplementation with the commercially available broccoli sprout extract capsules (BrocElite). Another intervention will consist of 4 days of daily supervised treadmill running. The exercise protocol consists of 4 minutes of high-intensity running running followed by a 3 minute recovery period, repeated for a total of 4 repetitions. The last intervention combines the above two and consists of 4 days of daily supplementation and daily supervised exercise training. Before and after each intervention, basic anthropometrics (weight, heart rate, and blood pressure) will be recorded, and a venous blood sample will be collected. Blood samples will be analyzed for metabolic and inflammatory markers. Participants will be asked to refrain from structured exercise, alcohol consumption, and broccoli consumption during each of the experimental periods. Before any testing, willing participants will provide informed consent, and fill out a few demographic, and lifestyle questionnaires. The study will be conducted at the University of British Columbia in Kelowna, BC, Canada.

Recruiting
Has No Placebo

Reichwald Health Sciences Centre

Image of Vanderbilt University Medical Center in Nashville, United States.

2-HOBA for Salt Sensitivity of Blood Pressure

18+
All Sexes
Nashville, TN

Hypertension is the leading cause of preventable deaths globally, driven by complications such as myocardial infarction, stroke, heart failure, and kidney disease. Recent updates in hypertension classification by the American Heart Association (AHA) place nearly half of the U.S. population in the hypertensive category. Excess dietary salt is a major risk factor for hypertension, with 50% of hypertensive individuals exhibiting salt-sensitivity of blood pressure (SSBP). SSBP is an independent predictor of cardiovascular events and death. While kidney mechanisms in salt-sensing have been extensively studied, emerging evidence suggests that immune cells can also sense sodium (Na+). This trial hypothesizes that myeloid cell-derived isolevuglandins (IsoLGs) drive endothelial dysfunction, perpetuating the salt-sensitive phenotype. Preliminary data indicate that targeting IsoLGs with the IsoLG scavenger 2-hydroxybenzylamine (2-HOBA) may interrupt this immune-vascular axis, reducing salt sensitivity and associated cardiovascular risks. This phase 2 clinical trial aims to investigate the role of 2-HOBA in modulating immune cell function within blood vessels in hypertensive patients. The study will explore the impact of immunity on salt sensitivity and assess 2-HOBA's potential to reduce endothelial dysfunction, improve immune cell activation, and alleviate SSBP.

Phase 2
Recruiting

Vanderbilt University Medical Center

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Image of University of Oklahoma Health Campus in Oklahoma City, United States.

Disulfiram for Rheumatoid Arthritis

18 - 75
All Sexes
Oklahoma City, OK

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation. Obesity is common among individuals with RA and is associated with increased disease activity, reduced treatment response, and worse functional outcomes. Inflammation in adipose tissue, driven in part by activation of the NLRP3 inflammasome and downstream gasdermin D (GSDMD)-mediated pathways, may contribute to systemic inflammation and RA disease severity. Disulfiram (DSF), an FDA-approved medication for alcohol use disorder, has recently been identified as an inhibitor of GSDMD-mediated inflammatory signaling and pyroptosis. Preclinical studies suggest that DSF reduces inflammasome activation, inflammatory cytokine release, and metabolic dysfunction. This study is a 12-week, randomized, double-blind, placebo-controlled pilot trial designed to evaluate the safety, tolerability, and preliminary efficacy of DSF in overweight and obese adults with active RA despite stable disease-modifying antirheumatic drug (DMARD) therapy. Participants will be randomized to receive either DSF (250 mg daily) or placebo. The primary objective is to assess safety and tolerability. Secondary and exploratory objectives include evaluating the effects of DSF on systemic inflammation, RA disease activity, metabolic parameters, and adipose tissue inflammasome activation. Findings from this study will inform the feasibility and design of larger clinical trials targeting GSDMD-mediated inflammation in RA.

Phase 2
Waitlist Available

University of Oklahoma Health Campus

Beatriz Y Hanaoka, MD, MSc

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