Vagifem

Atrophic Vaginitis, Low Testosterone, Hypogonadism + 27 more

Treatment

5 FDA approvals

20 Active Studies for Vagifem

What is Vagifem

Estradiol

The Generic name of this drug

Treatment Summary

Estradiol is a hormone naturally produced in females. It is used in hormone therapy to treat conditions related to low estrogen levels, such as hot flashes and vulvovaginal atrophy. It is available in many forms, including tablets, injections, vaginal rings, patches, sprays, gels, and creams. To increase its effectiveness when taken orally or through injection, estradiol is often combined with a pro-drug ester. Ethinyl estradiol is a synthetic form of estradiol that is more bioavailable and resistant to metabolism, making it the most common form used in combination oral contraceptive pills (

Estraderm

is the brand name

image of different drug pills on a surface

Vagifem Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Estraderm

Estradiol

1986

373

Approved as Treatment by the FDA

Estradiol, also known as Estraderm, is approved by the FDA for 5 uses like Breast Cancer and Hormonal Contraception .

Breast Cancer

Hormonal Contraception

Used to treat Hormonal Contraception therapy in combination with Levonorgestrel

Birth Control

Used to treat Contraception in combination with Levonorgestrel

Palliative Treatment

Breast Cancer

Effectiveness

How Vagifem Affects Patients

Estradiol is used to help relieve hot flashes, vaginal dryness, and pain during sex. It also helps increase bone density and can improve the levels of certain proteins in the liver. It can make blood clot more easily, which can increase the risk for heart disease, blood clots in veins, and stroke. Estradiol can also cause an increase in sodium retention and blood pressure.

How Vagifem works in the body

Estrogen is a hormone found in many parts of the body, like the breast, skin, and brain. In women of reproductive age, the majority of estrogen is made by the ovaries. After menopause, the main source of estrogen is the adrenal glands, which produce androstenedione and then turn it into estrone in other tissues. Estrogen works by binding to two types of receptors, ERα and ERβ, and GPER which helps it take effect quickly. When the receptor binds to estrogen, it travels to the nucleus of the cell and triggers gene transcription. This creates proteins which cause the effects of estrogen

When to interrupt dosage

The measure of Vagifem is founded upon the identified ailment, including Premature Menopause, Pharmaceutical Preparations and Postmenopause. The measure of dosage fluctuates as per the approach of delivery delineated in the table beneath.

Condition

Dosage

Administration

Hot Flashes

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

female castration

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

estradiol

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Vasomotor System

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Postmenopause

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Palliative Treatment

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Atrophic

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Pharmaceutical Preparations

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Prostate Cancer

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Hormone Replacement Therapy

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Breast Cancer

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Premature Menopause

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Therapeutic procedure

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Hypogonadism

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Osteoporosis

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Hot flashes

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Balanitis Xerotica Obliterans

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Breast

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Amenorrhea

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

hypoestrogenism

0.00052 mg/mg, , 0.005 mg/hour, 0.5 mg, 1.0 mg, 0.00025 mg/mg, 0.0005 mg/mg, 0.001 mg/mg, 2.0 mg, 0.0025 mg/hour, 0.0075 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.006 mg/hour, 1.53 mg, 0.0006 mg/mg, 10.0 mg/mL, 40.0 mg/mL, 20.0 mg/mL, 0.0014 mg/hour, 5.0 mg/mL, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 0.01 mg, 10.0 mg, 12.5 mg, 15.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 25.0 mg, 6.0 mg, 5.0 mg, 0.06 %, 4.0 mg, 8.0 mg, 0.1 %, 3.28 mg, 4.33 mg, 8.66 mg, 6.56 mg, 0.025 mg, 0.00075 mg/mg, 0.51 mg, 0.62 mg, 0.0001 mg/mg, 0.0045 mg/hour, 0.0052 mg/mg, 1.5 mg, 1.8 mg, 2.5 mg/mL, 0.45 mg, 0.9 mg, 0.05 mg, 0.004 mg, 0.0025 mg/mg, 2.17 mg, 6.57 mg, 4.84 mg, 4.95 mg, 14.0 mg, 0.005 mg/mg, 0.0075 mg/mg, 50.0 mg, 0.00125 mg/mg, 0.00005 mg/mg

Topical, Gel, metered, , Gel, metered - Topical, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Gel - Topical, Gel, Transdermal, Patch - Transdermal, Patch, Ring - Vaginal, Vaginal, Ring, Spray, Patch, extended release - Transdermal, Patch, extended release, Gel - Transdermal, Injection - Intramuscular, Spray, metered - Transdermal, Tablet, film coated - Vaginal, Spray, metered, Film, extended release - Transdermal, Film, extended release, Pellet, Pellet - Oral, Tablet - Vaginal, Oral; Transdermal, Insert - Vaginal, Insert, Cream, Cream - Vaginal, Injection, solution - Intramuscular, Gel, metered - Transdermal, Lotion - Topical, Emulsion, Emulsion - Topical, Spray - Transdermal, Intramuscular, Capsule - Oral, Pellet, implantable, Pellet, implantable - Subcutaneous, Capsule; Spray, metered, Cream - Transdermal, Capsule, Capsule; Spray, metered - Oral; Transdermal

Warnings

Vagifem has eighteen known contraindications and should be avoided for those experiencing the conditions given in the following table.

Vagifem Contraindications

Condition

Risk Level

Notes

Breast

Do Not Combine

Angioedema

Do Not Combine

Venous Thrombosis

Do Not Combine

undiagnosed abnormal genital bleeding

Do Not Combine

estrogen-dependent neoplasia

Do Not Combine

Liver Dysfunction

Do Not Combine

Breast

Do Not Combine

suspected pregnancy

Do Not Combine

Breast Cancer

Do Not Combine

Pulmonary Embolism

Do Not Combine

Angioedema

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Thromboembolism

Do Not Combine

Neoplasms, Hormone-Dependent

Do Not Combine

Pulmonary Embolism

Do Not Combine

Thromboembolism

Do Not Combine

Thrombophilia

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Estradiol may interact with Pulse Frequency

There are 20 known major drug interactions with Vagifem.

Common Vagifem Drug Interactions

Drug Name

Risk Level

Description

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Estradiol.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Estradiol.

Anastrozole

Major

The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estradiol.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Estradiol.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Estradiol.

Vagifem Toxicity & Overdose Risk

Studies have found that taking estradiol for 90 days in rats had no adverse effects at doses of 0.003 mg/kg/day. The lowest toxic dose for ethinyl estradiol is 21 mg/kg/21D for women. An overdose of estradiol may cause nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. If you suspect an overdose, it is recommended to stop taking the drug and get supportive care.

image of a doctor in a lab doing drug, clinical research

Vagifem Novel Uses: Which Conditions Have a Clinical Trial Featuring Vagifem?

867 ongoing studies are assessing the potential of Vagifem to alleviate Osteoporosis, absent menses for the preceding 6 months, and Urogenital Atrophy.

Condition

Clinical Trials

Trial Phases

Metastatic Breast Cancer

1 Actively Recruiting

Not Applicable

Breast Cancer

25 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1

Hysterectomy

6 Actively Recruiting

Phase 4, Not Applicable, Phase 3

estradiol

0 Actively Recruiting

Birth Control

14 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 2

Postmenopause

4 Actively Recruiting

Not Applicable, Phase 4

Osteoporosis, Postmenopausal

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

moderate to severe symptoms

0 Actively Recruiting

Balanitis Xerotica Obliterans

0 Actively Recruiting

Amenorrhea

0 Actively Recruiting

Osteoporosis

25 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 2

Prostate Cancer

68 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1

Breast

0 Actively Recruiting

Urogenital atrophy

0 Actively Recruiting

Low Testosterone

4 Actively Recruiting

Phase 1, Phase 4, Phase 2, Phase 3

Vasomotor System

0 Actively Recruiting

Atrophic Vaginitis

1 Actively Recruiting

Not Applicable

Hot flashes

31 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 3, Phase 1

Hormone Replacement Therapy

0 Actively Recruiting

Vagifem Reviews: What are patients saying about Vagifem?

4.3

Patient Review

5/16/2022

Vagifem for Postmenopausal Urethral Atrophy

As someone who has gone through menopause, I've found this treatment to be very effective for my bladder problems and dry vagina. I haven't experienced any negative side effects, though there is the occasional thrush infection which may be caused by the applicator. Overall, this has worked well for me.

3.7

Patient Review

5/11/2022

Vagifem for Wasting of Tissues of the Vulva

I've gained nine pounds, my breasts are larger and tender, my hair is falling out more quickly, I feel breathless and get mild headaches. While the moisturizing effect seems to have decreased, I do feel more comfortable deep inside and no longer feel like I have a UTI brewing all the time.

3

Patient Review

8/9/2022

Vagifem for Postmenopausal Urethral Atrophy

I initially had no issues with this medication, but after about a month I started to experience really unpleasant side effects like bloating, leg cramps, and hair loss. I'm hoping to speak to my doctor soon about discontinuing use.

3

Patient Review

11/6/2022

Vagifem for Vaginal Inflammation due to Loss of Hormone Stimulation

I did not do my research on this medication before taking it, and I regret that now. I can't say for certain whether or not Vagifem is causing my problems, but it's certainly possible. I've been experiencing extreme bloating and pelvic pain which has made daily life very difficult. Additionally, I'm constantly feeling the need to urinate. The one side effect that concerns me most after reading these reviews is hair loss. I have already lost 50% of my hair, and the texture has changed for the worse. As of now, I will be stopping use of this medication."

2.7

Patient Review

4/29/2022

Vagifem for Vaginal Inflammation due to Loss of Hormone Stimulation

I used this for five months to try and alleviate vaginal atrophy, but it only made the burning and stinging sensations worse. It also seemed to make my slight vaginal prolapse much worse. On top of all that, I got the worst thrush ever. So, on balance, I think I would have been better off without it.

2.7

Patient Review

5/5/2022

Vagifem for Postmenopausal Urethral Atrophy

I developed a really bad itch and discharge after using this for about eight days. It was like a yeast infection, so I stopped taking it immediately.

2.3

Patient Review

4/20/2022

Vagifem for Wasting of Tissues of the Vulva

The new Vagirux applicator is too shallow and the tablet falls out constantly.

1

Patient Review

3/14/2022

Vagifem for Marked Inflammation of Urethra, the Canal that leads From the Bladder

I've only been using this medication for four days, and I woke up this morning in excruciating pain. I'm continuing to take it as directed because I need a smear test, but the pain is unbearable. I don't know how I'm supposed to make it through 10 more days of this.

1

Patient Review

10/11/2022

Vagifem for Vaginal Inflammation due to Loss of Hormone Stimulation

The burning was unbearable and I felt like I had to constantly go to the bathroom. The pressure in my bladder was really intense.

1

Patient Review

2/25/2022

Vagifem for Vaginal Inflammation due to Loss of Hormone Stimulation

I have Ehlers-Danlos Syndrome and this medication made me very sick.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about vagifem

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the risks of taking Vagifem?

"Vagifem® users most often reported experiencing headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection."

Answered by AI

How quickly will Vagifem work?

"A study found that the drug Vagifem 10 mcg helped to reduce symptoms associated with vaginal atrophy in most women after 12 weeks of treatment, though some women reported seeing improvements as early as 8 weeks into treatment."

Answered by AI

What does Vagifem do for a woman?

"This medication is used to help reduce vaginal symptoms of menopause in women. These symptoms are caused by the body making less estrogen and can include vaginal dryness, burning, and itching."

Answered by AI

How long should you stay on Vagifem?

"It is currently recommended to continue using local estrogen therapy for as long as it is needed for symptom control. A study that looked back at data from over 13,000 women showed that, in the real world, local estrogen therapy is typically used for around 12 months."

Answered by AI

Clinical Trials for Vagifem

Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Internet-Delivered Cognitive Behavioural Therapy for Hot Flashes

40 - 60
Female
Hamilton, Canada

Given the impact that hot flashes and night sweats can have on daily life during the menopausal transition, our team has developed a therapist-guided online cognitive behavioural therapy (CBT)- based program to help individuals manage these symptoms. An online program may help address systemic barriers to in-person care, such as cost, time, travel, and caregiving needs. The broad aim of this pilot clinical trial is to examine the experience of a four-week therapist-guided online CBT-based program for menopause-related hot flashes and night sweats. The primary objective of this study is to evaluate the acceptability and feasibility of the four-week online program, including how participants experience the program and how well they are able to complete it at home. The secondary objective is to explore whether the program may help with hot flashes and night sweats, and related concerns such as sleep, mood, anxiety, and quality of life. Exploratory analyses will examine whether changes in these outcomes are maintained three months after completing the program. Researchers will compare participants who receive the program immediately with participants who wait four weeks before receiving it. Participants will: * Complete online questionnaires about their symptoms and well-being. * Complete four weekly online lessons and activities. * Meet briefly with a guide each week for guidance and support. * Complete follow-up questionnaires after the program and three months later.

Waitlist Available
Has No Placebo

St. Joseph's Healthcare Hamilton

Sheryl M Green, PhD, CPsych

Image of MusB Research LLC in New Port Richey, United States.

Ashoka Bark and Shatavari for Menopause

40 - 65
Female
New Port Richey, FL

This 12-week randomized, placebo-controlled clinical trial will evaluate the efficacy and safety of a daily oral supplement containing Ashoka Bark and Shatavari in women experiencing menopausal symptoms. Up to 50 participants will be randomized to receive either the active supplement or placebo, with 40 participants expected to complete the study. Participants will attend visits at Weeks 0, 6, and 12, where hormone levels (FSH and estradiol), menopausal symptoms, quality of life, anxiety, cognitive function, and sleep will be assessed using validated measures. The study will also explore changes in the vaginal microbiome and monitor safety and adherence throughout the trial. The study will be conducted at MusB Research in New Port Richey, Florida.

Recruiting
New This Month

MusB Research LLC

Vidya USA Corporation

Image of Emory Proton Therapy Center in Atlanta, United States.

Imaging Techniques for Prostate Cancer

18+
Male
Atlanta, GA

This clinical trial studies the safety of a computed tomography (CT) scan, with or without a magnetic resonance imaging (MRI) scan, in planning for high-dose-rate (HDR) prostate brachytherapy treatment in patients with prostate cancer. Brachytherapy is a type of radiation therapy in which radioactive implants, such as pellets, seeds, ribbons, wires, needles, balloons, or capsules, are placed in the body, directly into or near the tumor. The radiation is delivered through a flexible tube called a catheter or a larger device called an applicator. Treatment planning, or simulation, is a process used to plan radiation therapy so that the target area is precisely located and marked. A CT scan is a procedure that uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-dimensional views of tissues and organs. An MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. The addition of MRI to CT for HDR prostate brachytherapy treatment planning may help patients have less urine leakage and less pain after treatment.

Waitlist Available
Has No Placebo

Emory Proton Therapy Center (+2 Sites)

Kamran Salari, MD

Have you considered Vagifem clinical trials?

We made a collection of clinical trials featuring Vagifem, we think they might fit your search criteria.
Go to Trials

Have you considered Vagifem clinical trials?

We made a collection of clinical trials featuring Vagifem, we think they might fit your search criteria.
Go to Trials
Image of Clinical and Translational Science Center, Weill Cornell Medical College in New York, United States.

Treatment for Menopause

40 - 90
Female
New York, NY

This study will compare adherence, tolerability, safety, and treatment satisfaction between a calcium-rich food and a traditional calcium carbonate supplement in women ages 40 to 90 who are at increased risk for osteoporosis. Participants will be randomly assigned to receive either a calcium-rich food providing 500 mg of calcium from milk-derived minerals or a 500 mg calcium carbonate supplement once daily for four weeks. Participants will complete brief weekly questionnaires assessing supplement use, gastrointestinal symptoms, and treatment satisfaction. The goal of the study is to determine whether the form in which calcium is consumed influences adherence and participant experience. No blood draws, imaging studies, or other invasive procedures are involved

Waitlist Available
Has No Placebo

Clinical and Translational Science Center, Weill Cornell Medical College

Jeff Zhu

Image of Rocky Mountain Regional VA Medical Center, Aurora, CO in Aurora, United States.

Testosterone Therapy for Spinal Cord Injury

18+
Male
Aurora, CO

Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life. These deficits result from reduced activity after SCI and may be worsened by low testosterone, which is present in many men with SCI. In older men with low testosterone who do not have SCI, testosterone therapy (TRT) is known to increase muscle mass, muscle strength, and bone mineral density, and to reduce body fat. However, it is not known if TRT is effective in men with SCI. The purposes of this study are to determine the effectiveness of TRT in men who have low testosterone and difficulty walking after chronic motor incomplete SCI and to assess whether a process in the body that changes testosterone to dihydrotestosterone (DHT; another hormone that is stronger than testosterone) impacts the effectiveness of TRT in the impaired lower limbs and in other tissues after SCI. The researchers hypothesize that TRT will improve muscle and bone in the impaired limbs of men with chronic incomplete SCI and reduce fat mass, and that finasteride (a drug that blocks that blocks a process that changes testosterone to DHT) will influence prostate symptoms but not the musculoskeletal or body composition benefits produced by TRT.

Phase 2 & 3
Waitlist Available

Rocky Mountain Regional VA Medical Center, Aurora, CO (+3 Sites)

Joshua F Yarrow, PhD MS BS

Image of UConn Health in Farmington, United States.

Educational Videos for Pre-operative Anxiety

18+
Female
Farmington, CT

The goal of this clinical trial is to learn if educational videos can reduce pre-operative anxiety in patients undergoing minimally invasive gynecologic surgery. The main question it aims to answer are: do patient education videos decrease preoperative anxiety? do patient education videos increase patient preparedness for surgery? Researchers will compare the group who watched the videos preoperatively to the group who only underwent the usual counseling at the preoperative visit to see if the results of a survey that measures anxiety and preparedness differ. Participants will be randomly assigned to one of two groups: one group that will be asked to watch the educational videos and one group that will not. All participants will attend their pre-operative appointment as usual and complete a survey afterwards.

Waitlist Available
Has No Placebo

UConn Health

Have you considered Vagifem clinical trials?

We made a collection of clinical trials featuring Vagifem, we think they might fit your search criteria.
Go to Trials