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40 Participants NeededMy employer runs this trial

Estradiol for Brain Health in Menopause

(CEREBRA Trial)

RS
Overseen ByResearch Services Professional
Age: 18 - 65
Sex: Female
Trial Phase: Phase 4
Sponsor: University of Colorado, Denver
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to learn more about how estradiol patch treatment affects brain processes, health, and wellbeing.

Who Is on the Research Team?

NE

Neill Epperson, MD

Principal Investigator

University of Colorado, Denver

Are You a Good Fit for This Trial?

This trial is for healthy postmenopausal adults. Participants should not have any major health issues that would prevent them from safely using estradiol patches.

Inclusion Criteria

Ability to give written informed consent
Fluent in written and verbal English, may use Spanish to speak with study staff if preferred
Participants must be up to date on age-appropriate cancer screening, including pap smear within previous 3 years and mammogram within previous 2 years
See 5 more

Exclusion Criteria

Current psychiatric diagnosis as assessed by Mini International Neuropsychiatric Interview (MINI)
History of suicidal behavior within past 2 years
Active psychiatric illness within previous 12 months or lifetime diagnosis of psychotic disorder
See 18 more

What Are the Treatments Tested in This Trial?

Interventions

  • Continuous Estradiol
  • Cyclic Estradiol

Trial Overview

The study compares two ways of giving estradiol hormone therapy through skin patches: one group gets it in cycles, and the other gets a steady, constant dose. The goal is to see how each method affects brain health and wellbeing.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Cyclic EstradiolExperimental Treatment1 Intervention
Group II: Continuous EstradiolExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1,842
Recruited
3,028,000+

Pedersen Foundation

Collaborator

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