Tele-CE for Severe Stroke
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke.
The main questions the investigators aim to answer are:
* What are the effects of home-based cross-education on lower limb neuroplasticity?
* What are the effects of home-based cross-education on lower limb function?
* Is home-based cross-education feasible to administer and accepted by participants?
Participants will take part in ten home-based, remotely supervised sessions, during which participants will either perform unilateral skill and strength training of the unaffected lower limb (Tele-Cross Education or Tele-CE) or cognitive training and unilateral movements of the unaffected lower limb (Tele-control). Each participant will experience measures of brain and spinal activity and motor function testing before and after both sessions (Tele-CE and Tele-control). Each participant will also be asked to fill out a feedback questionnaire to assess acceptability after intervention sessions (Tele-CE and Tele-control).
Are You a Good Fit for This Trial?
This trial is for adults who had a single, severe stroke over 6 months ago affecting one side of the brain. Participants must have significant lower limb weakness but still be able to move their unaffected ankle. People with certain medical devices, skin issues, recent seizures or concussions, other neurological disorders, or trouble understanding instructions cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in ten home-based, remotely supervised sessions of either Tele-Cross Education or Tele-Control, including skill and strength training or cognitive training and unilateral movements.
Assessment
Measures of brain and spinal activity and motor function testing are conducted before and after intervention sessions.
Follow-up
Participants are monitored for changes in corticomotor excitability, transcallosal inhibition, cutaneous reflex excitability, muscle strength, walking speed, walking endurance, and physical activity levels.
Feedback
Participants complete a feedback questionnaire to assess acceptability and perceived satisfaction of the intervention.
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares two types of home-based training done through video calls: one group does skill and strength exercises with their stronger leg (Tele-CE), while the other does cognitive tasks and simple movements (Tele-control). Both groups are supervised remotely and tested before and after sessions.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
While seated, participants will begin with 15 minutes of game-based ankle skill training of the unaffected lower limb. Participants will perform skilled dorsiflexion and plantarflexion movements of the unaffected ankle to play simple and engaging games. Three game blocks will be played (5 mins/block) with 1-minute rest between blocks. Following this, participants will engage in unaffected leg strength training using a theraband targeting hip flexors, hip abductors, hip adductors, knee flexors, knee extensors, and ankle plantarflexors. Participants will perform 3 sets of 10 repetitions for each muscle group.
While seated, participants will begin with 15 minutes of cognitive training using games focusing on memory and executive function. Participants will play three cognitive games (5 minutes each with 1-min rest between blocks). Following this, participants will engage in unilateral leg movements of the unaffected hip flexors, hip abductors, hip adductors, knee flexors, knee extensors, and ankle plantarflexors. Participants will perform 3 sets of 10 repetitions of movements for each muscle group.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Illinois at Chicago
Lead Sponsor
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