Modular Powered Orthoses for Knee Arthritis

This trial tests a wearable device, known as a modular powered orthosis (exoskeleton), to assist individuals with knee osteoarthritis. The goal is to determine if this device can ease knee pain and reduce muscle effort during daily activities by taking on some of the work usually done by muscles. It targets individuals medically diagnosed with knee osteoarthritis who experience significant pain during daily activities. Participants should be able to walk for six minutes without assistance from another person and manage stairs or ramps, even if using a walking aid. As an unphased trial, this study provides a unique opportunity to explore innovative solutions for managing knee osteoarthritis pain.

Research has shown that powered exoskeletons are generally safe for people with knee arthritis. Studies have found that these devices can reduce stress on the knee and improve movement without surgery, making them well-received by users. For instance, the Ascend exoskeleton is lightweight and provides crucial knee support for those with osteoarthritis.

Unlike traditional treatments for knee arthritis, which mainly include pain medications, physical therapy, and sometimes surgery, the modular powered orthosis offers a unique approach. This wearable exoskeleton not only supports the knee but also assists with movement, potentially reducing pain and improving mobility. Researchers are excited because it could provide immediate support and relief without the need for drugs or invasive procedures, offering a new, non-invasive way to manage knee arthritis.

This trial will evaluate the effectiveness of modular powered orthoses, such as exoskeletons, in reducing knee strain. Studies have shown that these devices can significantly reduce strain on knee muscles. For instance, one study found that wearing an exoskeleton lowered muscle activity by 44.8–71.5%. Another study demonstrated that participants walked 24.11% faster and took steps 7.41% longer, indicating improved movement. These exoskeletons support the knee by sharing some of the joint's workload, which can alleviate pain for individuals with osteoarthritis. By easing the strain on muscles during everyday activities, they can effectively manage knee pain. Participants in this trial will perform various tasks while wearing the modular powered orthosis to assess these benefits.⁶⁷⁸⁹¹⁰