Magnesium Choline Citrate for Cognitive Functioning
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether Magnesium Choline Citrate, a dietary supplement, can enhance memory, focus, and attention in healthy teens and adults while reducing anxiety. Participants will take either the supplement or a placebo for 84 days to observe any changes in cognitive function and anxiety levels. Ideal participants are generally healthy individuals who have noticed issues with memory, focus, or attention and are willing to maintain their current lifestyle during the trial.
As an unphased trial, this study provides participants the chance to contribute to scientific understanding and potentially experience personal cognitive benefits.
Is there any evidence suggesting that Magnesium Choline Citrate is likely to be safe for humans?
Research has shown that Magnesium Choline Citrate is generally safe for people. In one study, participants received a high dose of 2000 mg per kilogram, experiencing no serious side effects over 14 days. Another study, lasting 90 days, tested doses of 100, 350, and 1000 mg per kilogram per day, with no deaths or severe side effects reported.
These findings suggest that Magnesium Choline Citrate is safe, with no major negative effects observed at various doses. As this trial involves healthy teenagers and adults, the treatment is expected to be similarly well-tolerated.12345Why are researchers excited about this trial?
Unlike the standard treatments for cognitive function, which often focus on stimulating neurotransmitter activity or improving blood flow, Magnesium Choline Citrate introduces a unique approach by combining magnesium and choline. This combination targets cognitive health by potentially enhancing neuronal communication and supporting brain cell membrane integrity. Researchers are excited about this treatment because magnesium is known for its role in neuroprotection, while choline is essential for producing acetylcholine, a neurotransmitter crucial for memory and learning. By addressing these foundational aspects of brain health, Magnesium Choline Citrate offers a novel potential advantage over existing options.
What evidence suggests that Magnesium Choline Citrate might be an effective treatment for cognitive function?
Research has shown that magnesium plays a crucial role in brain health and cognitive function. Studies have found that magnesium supplements can enhance memory and thinking skills by increasing magnesium levels in the brain. Additionally, choline, a component of Magnesium Choline Citrate, is associated with improved brain health. Higher choline intake correlates with a reduced risk of memory problems in aging individuals. This trial will test Magnesium Choline Citrate, which may support brain function by improving magnesium absorption and promoting brain health. Participants in this trial will receive either Magnesium Choline Citrate or a placebo.678910
Who Is on the Research Team?
David Crowley
Principal Investigator
KGK Science Inc.
Are You a Good Fit for This Trial?
This trial is for healthy adolescents (8-17 years) and adults (18+ years) who want to see if Magnesium Choline Citrate can improve thinking skills or reduce anxiety. People with serious health issues or on conflicting medications may not be eligible.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume either Magnesium Choline Citrate or placebo for 84 days and complete weekly questionnaires and study diaries
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Magnesium Choline Citrate
Trial Overview
The study compares taking Magnesium Choline Citrate versus a placebo daily for 84 days to see if it helps with cognitive function and anxiety. Participants complete regular questionnaires and keep a weekly diary. The trial is virtual.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Find a Clinic Near You
Who Is Running the Clinical Trial?
Nutrisol, LLC
Lead Sponsor
KGK Science Inc.
Industry Sponsor
Najla Guthrie
KGK Science Inc.
Chief Executive Officer since 1997
Research career at the Centre for Human Nutrition, University of Western Ontario
Dr. Bibiane Zakaria
KGK Science Inc.
Chief Medical Officer since 2023
MD from an unspecified institution
Citations
1.
nutraceuticalsworld.com
nutraceuticalsworld.com/breaking-news/magtein-improves-cognitive-performance-equivalent-to-7-5-years-of-brain-aging-study/Magtein Improves Cognitive Performance Equivalent to 7.5 ...
“The 7.5-year reduction in brain cognitive age is particularly exciting, as it demonstrates Magtein's potential to support healthy brain aging.”.
How Does Choline Citrate Help Increase the Cellular ...
On this edition of "Ask Dr. J", A customer writes in to ask Dr. J about how Choline Citrate helps with the cellular uptake of Magnesium.
3.
scitechdaily.com
scitechdaily.com/magnesium-supplements-could-improve-memory-and-cognitive-ability/Magnesium Supplements Could Improve Memory and ...
It contains magnesium threonate, and tests have shown that the compound boosts levels of magnesium in rats' brains by 15% after 24 days. Roughly ...
New Research Study Reveals Critical Role of Magnesium ...
Magnesium, an essential mineral, plays a vital role in brain function and cognitive health, according to groundbreaking research published in ...
5.
facebook.com
facebook.com/betterbonesbetterbody/videos/how-choline-citrate-helps-with-absorption-of-magnesium/1152439131850462/Dr. Brown explains how choline, one of the nutrients ...
He states that these alkalizing elements help the body better absorb magnesium, which is essential for overall health and strong bones. The post ...
and Repeated-Dose Oral Toxicity Studies of Citicoline Free ...
In an acute 14-day study, 2000 mg/kg was well tolerated. In a 90-day study, 100, 350, and 1000 mg/kg/day doses resulted in no mortality.
Cognitive Deterioration and Associated Pathology Induced by ...
We surmised that this rat with early onset cognitive deterioration and the two rats that developed cognitive deterioration after consuming the intermediate Al ...
8.
nmnbio.co.uk
nmnbio.co.uk/blogs/news/brain-fog-supplements?srsltid=AU7gw4UT2rRvcU0U8_teEPg9Zqw1j7KnsiZzUX-_1j2phCWXjr5BRHN8Brain Fog Supplements: The 7 That Have Actual Evidence ...
A Cochrane review of citicoline in cognitive impairment found positive effects across multiple cognitive domains. It is one of the few ...
(PDF) Single- and Repeated-Dose Oral Toxicity Studies of ...
There are modest, but statistically significant, beneficial effects of CDP-choline on memory function and behaviour.
Effects of Magnesium Forms on the ...
Effects of a novel magnesium complex on metabolic and cognitive functions and the expression of synapse-associated proteins in rats fed a ...
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