Functional Resistance Training for Cancer Survivors

(ACES Trial)

This trial aims to evaluate the effectiveness of live, online supervised group resistance training for older cancer survivors. Participants will be divided into three groups: one will engage in immediate resistance exercises (Functional Resistance Training), another will perform stretching as a placebo, and a third will begin resistance exercises later (Delayed Functional Resistance Training). The trial focuses on improving daily function for those who struggle with everyday tasks. Ideal candidates are aged 65 and older, diagnosed with cancer within the last five years, experiencing some difficulty with daily activities, and currently not exercising much. Participants should be comfortable with online sessions and willing to join any of the study groups. This unphased trial offers a unique opportunity to contribute to research that could enhance the quality of life for older cancer survivors.

The trial does not specify if you need to stop taking your current medications. However, if you are on a medication that affects movement or is not safe with exercise, you might not be able to participate.

A previous study reported no negative side effects after resistance training in older cancer patients. Research has shown that resistance training is generally safe for cancer survivors. It is well-tolerated, and many studies indicate it can boost muscle strength and physical ability.

This trial focuses on functional resistance training, which includes movements similar to daily activities. Participants will perform exercises like standing up from a chair and doing push-ups. The exercises start easy and gradually become more challenging, helping participants adjust to the training safely.

Researchers are excited about the functional resistance training program for cancer survivors because it offers a unique approach to rehabilitation by integrating exercises that mimic everyday movements. Unlike standard rehabilitation options, which often focus on general strength or cardiovascular fitness, this program targets functional movements like chair stands, step-ups, and plank holds, aiming to improve the daily living activities of cancer survivors. Additionally, the training is delivered online and supervised live, making it accessible for participants who may face barriers to in-person sessions. This approach not only personalizes the exercise regimen to individual tolerance levels but also provides a progressive, structured plan that can adjust over time, potentially leading to better adherence and outcomes for participants.

Research has shown that resistance training benefits cancer survivors. One study found that it boosts muscle strength and eases everyday tasks. Another study discovered that it improves quality of life and reduces fatigue for those undergoing chemotherapy. Some evidence even suggests that resistance training might increase survival rates in breast cancer patients. In this trial, participants in Arm I will engage in an immediate functional resistance training program, while those in Arm III will start the same program after a 16-week delay. Overall, resistance training supports strength, stamina, and general physical health in cancer survivors.²³⁴⁶⁷