Fermented Foods for Spinal Cord Injury
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether a diet rich in fermented foods can improve bowel function and gut health in individuals with chronic spinal cord injury (SCI). Researchers will compare the effects of a high fermented food diet to a regular diet on bowel symptoms and gut bacteria composition. Participants must have experienced spinal cord injury for over a year and face bowel challenges, such as having fewer than three bowel movements a week or needing over an hour for each bowel routine. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance the quality of life for SCI patients.
What prior data suggests that consuming fermented foods is safe for adults with spinal cord injury?
Research has shown that fermented foods can benefit health by reducing cancer risk and inflammation. People have safely consumed these foods for hundreds of years. However, some individuals might experience mild reactions, such as headaches or skin irritations, due to histamine, a substance in fermented foods.
Studies also suggest that fermented foods can improve gut health by supporting beneficial bacteria in the stomach and intestines. Although specific research on individuals with spinal cord injuries is limited, fermented foods are generally considered safe.
For those considering participation in a clinical trial involving fermented foods, it's important to note that side effects are usually mild and rare. Participants will gradually increase their intake to minimize any discomfort.12345Why are researchers excited about this trial?
Unlike the standard of care for spinal cord injury, which often includes medications, physical therapy, and sometimes surgery, the use of fermented foods offers a new dietary approach. This treatment is unique because it leverages the benefits of probiotics and diverse microbiota to potentially improve recovery and overall health. Researchers are excited about this because fermented foods are natural, widely accessible, and might promote neurological repair and reduce inflammation by enhancing gut health. This approach could offer a holistic complement to existing treatments, focusing on dietary changes rather than conventional medical interventions.
What evidence suggests that a high fermented food diet could improve bowel function and gut health in adults with chronic spinal cord injury?
This trial will compare the effects of fermented foods with a control diet in people with spinal cord injuries (SCI). Research has shown that fermented foods can benefit individuals with SCI. Specifically, studies have found that kefir, a type of fermented milk drink, can protect nerve cells from damage. This protection is crucial for those with SCI as it might prevent further nerve damage. Fermented foods contain beneficial bacteria, which can enhance gut health by increasing the variety of helpful organisms in the intestines. A healthy gut is linked to better digestion and reduced inflammation, which can significantly aid bowel function in people with SCI. Although direct evidence from human studies remains limited, these early findings suggest that consuming more fermented foods might improve bowel function and overall gut health in individuals with spinal cord injuries.678910
Are You a Good Fit for This Trial?
This trial is for adults aged 18-70 who have had a spinal cord injury (neck or upper back) for at least one year, are medically stable, and have ongoing bowel problems like infrequent movements, long routines, incomplete evacuation, or bloating. Participants must be able to safely eat fermented foods.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Ramp-up Treatment
Participants gradually increase fermented food intake from 2 to 6 servings/day over 3 weeks
Full-intake Treatment
Participants consume ≥6 servings/day of fermented foods, rotating through categories to ensure diversity
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Fermented Foods
Trial Overview
The study compares a high fermented food diet to a regular control diet over 10 weeks in people with chronic spinal cord injury. It looks at whether eating more fermented foods improves bowel function and gut health using stool samples and X-rays.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Fermented food arm: participants randomized to the fermented foods arm will consume ≥6 servings/day of fermented foods after a graded ramp-up to minimize intolerance. A 3-week ramp-up (weeks 1-3) will increase intake from 2 to 6 servings/day, followed by a 7-week full-intake phase (weeks 4-10). To avoid single-food dominance and improve microbiome diversity, participants will be required to consume ≥3 categories/day (e.g., vegetables, dairy, soy, tea, brine) and rotate through all core fermented food categories and consume a variety of items across a 2-3-day period. This will ensure all core items are consumed throughout the week. Core food items will be delivered biweekly.
Participants randomized to the control arm will receive non-fermented versions of the base foods consumed by the fermented foods arm and will be instructed to avoid fermented foods during the trial.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor
Citations
Fermented Foods for Spinal Cord Injury · Info for Participants
The study compares a high fermented food diet to a regular control diet over 10 weeks in people with chronic spinal cord injury. It looks at whether eating more ...
Unraveling Spinal Cord Injury Nutrition: Effects of Diet on the ...
Kefir, a probiotic-rich fermented dairy product, has shown neuroprotective effects in animal models by reducing neuronal damage, lowering oxidative and related ...
Nutritional alterations, adverse consequences, and ...
Spinal cord injury (SCI) leads to complex nutritional alterations, including energy imbalance, contribute to increased risks of obesity, ...
Eat Well, Live Well with Spinal Cord Injury
Eat fermented foods. Fermented foods are high in good bacteria. Fermenting is the process where good bacteria is used to break down carbohydrates and ...
Nutrition and Spinal Cord Injury
It is common for people to take in too much sodium by eating processed and fast foods. Instead, focus on fruits and vegetables, whole grains, and lean meats ...
6.
semanticscholar.org
semanticscholar.org/paper/Nutrition-management-of-spinal-cord-injured-an-of-Wong/9e2bb6131243af1212b4b1db7e23970b196576da[PDF] Nutrition management of spinal cord injured patients
It was found that AAD is common in SCI patients and may be a risk factor for a poorer outcome and increased hospital costs and Polypharmacy
pathophysiology of spinal cord injury and potential health ...
Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat.
(PDF) Award Eligible Papers
There is limited evidence of probiotic effectiveness, however, in patients with spinal cord injuries (SCI). Overall, 64.5% of patients were at ...
Fermentation-enabled wellness foods: A fresh perspective
Herein, recent research relating to the manufacture of fermented foods are critically reviewed, placing emphasis on the potential health ...
Special Issue : Fermented Foods and Their Health Benefits
Various scientific reports claim that fermented foods have anti-cancer and/or anti-inflammatory properties.
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