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Fermented Foods for Spinal Cord Injury

JL
Overseen ByJia Li, PhD

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether a diet rich in fermented foods can improve bowel function and gut health in individuals with chronic spinal cord injury (SCI). Researchers will compare the effects of a high fermented food diet to a regular diet on bowel symptoms and gut bacteria composition. Participants must have experienced spinal cord injury for over a year and face bowel challenges, such as having fewer than three bowel movements a week or needing over an hour for each bowel routine. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance the quality of life for SCI patients.

What prior data suggests that consuming fermented foods is safe for adults with spinal cord injury?

Research has shown that fermented foods can benefit health by reducing cancer risk and inflammation. People have safely consumed these foods for hundreds of years. However, some individuals might experience mild reactions, such as headaches or skin irritations, due to histamine, a substance in fermented foods.

Studies also suggest that fermented foods can improve gut health by supporting beneficial bacteria in the stomach and intestines. Although specific research on individuals with spinal cord injuries is limited, fermented foods are generally considered safe.

For those considering participation in a clinical trial involving fermented foods, it's important to note that side effects are usually mild and rare. Participants will gradually increase their intake to minimize any discomfort.12345

Why are researchers excited about this trial?

Unlike the standard of care for spinal cord injury, which often includes medications, physical therapy, and sometimes surgery, the use of fermented foods offers a new dietary approach. This treatment is unique because it leverages the benefits of probiotics and diverse microbiota to potentially improve recovery and overall health. Researchers are excited about this because fermented foods are natural, widely accessible, and might promote neurological repair and reduce inflammation by enhancing gut health. This approach could offer a holistic complement to existing treatments, focusing on dietary changes rather than conventional medical interventions.

What evidence suggests that a high fermented food diet could improve bowel function and gut health in adults with chronic spinal cord injury?

This trial will compare the effects of fermented foods with a control diet in people with spinal cord injuries (SCI). Research has shown that fermented foods can benefit individuals with SCI. Specifically, studies have found that kefir, a type of fermented milk drink, can protect nerve cells from damage. This protection is crucial for those with SCI as it might prevent further nerve damage. Fermented foods contain beneficial bacteria, which can enhance gut health by increasing the variety of helpful organisms in the intestines. A healthy gut is linked to better digestion and reduced inflammation, which can significantly aid bowel function in people with SCI. Although direct evidence from human studies remains limited, these early findings suggest that consuming more fermented foods might improve bowel function and overall gut health in individuals with spinal cord injuries.678910

Are You a Good Fit for This Trial?

This trial is for adults aged 18-70 who have had a spinal cord injury (neck or upper back) for at least one year, are medically stable, and have ongoing bowel problems like infrequent movements, long routines, incomplete evacuation, or bloating. Participants must be able to safely eat fermented foods.

Inclusion Criteria

I am between 18 and 70 years old.
At least 1 year post-onset of spinal cord injury, consistent with chronic spinal cord injury
I have a spinal cord injury in my neck or upper back.
See 5 more

Exclusion Criteria

I cannot safely have a Sitz marker test or abdominal X-rays.
I have an active gastrointestinal disease like Crohn's, colitis, or celiac disease.
I have taken antibiotics in the past 4 weeks.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Ramp-up Treatment

Participants gradually increase fermented food intake from 2 to 6 servings/day over 3 weeks

3 weeks
1 visit (in-person)

Full-intake Treatment

Participants consume ≥6 servings/day of fermented foods, rotating through categories to ensure diversity

7 weeks
1 visit (in-person), biweekly monitoring contacts

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Fermented Foods

Trial Overview

The study compares a high fermented food diet to a regular control diet over 10 weeks in people with chronic spinal cord injury. It looks at whether eating more fermented foods improves bowel function and gut health using stool samples and X-rays.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: Fermented Food ArmExperimental Treatment2 Interventions
Group II: Control Diet ArmPlacebo Group2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Ohio State University

Lead Sponsor

Trials
891
Recruited
2,659,000+

Citations

Fermented Foods for Spinal Cord Injury · Info for Participants

The study compares a high fermented food diet to a regular control diet over 10 weeks in people with chronic spinal cord injury. It looks at whether eating more ...

Unraveling Spinal Cord Injury Nutrition: Effects of Diet on the ...

Kefir, a probiotic-rich fermented dairy product, has shown neuroprotective effects in animal models by reducing neuronal damage, lowering oxidative and related ...

Nutritional alterations, adverse consequences, and ...

Spinal cord injury (SCI) leads to complex nutritional alterations, including energy imbalance, contribute to increased risks of obesity, ...

Eat Well, Live Well with Spinal Cord Injury

Eat fermented foods. Fermented foods are high in good bacteria. Fermenting is the process where good bacteria is used to break down carbohydrates and ...

Nutrition and Spinal Cord Injury

It is common for people to take in too much sodium by eating processed and fast foods. Instead, focus on fruits and vegetables, whole grains, and lean meats ...

[PDF] Nutrition management of spinal cord injured patients

It was found that AAD is common in SCI patients and may be a risk factor for a poorer outcome and increased hospital costs and Polypharmacy

pathophysiology of spinal cord injury and potential health ...

Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat.

(PDF) Award Eligible Papers

There is limited evidence of probiotic effectiveness, however, in patients with spinal cord injuries (SCI). Overall, 64.5% of patients were at ...

Fermentation-enabled wellness foods: A fresh perspective

Herein, recent research relating to the manufacture of fermented foods are critically reviewed, placing emphasis on the potential health ...

Special Issue : Fermented Foods and Their Health Benefits

Various scientific reports claim that fermented foods have anti-cancer and/or anti-inflammatory properties.