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96 Participants NeededMy employer runs this trial

Intervention Strategies for Human Papillomavirus Vaccination

(HERO Trial)

MV
NN
Overseen ByNinh Nguyen
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Northwestern University
Disqualifiers: Moving, Language fluency, Consent
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of the HERO study is to leverage the Multiphase Optimization Strategy (MOST) framework to conduct a pilot trial testing four different intervention components (expert video, self-persuasion, narrative storytelling, and motivational interviewing) targeting HPV vaccination among U.S. Vietnamese.

PRIMARY AIM To assess the feasibility and acceptability of each of the four digital HERO intervention components in a pilot optimization trial using the MOST framework. Using a highly efficient design, the study team will randomize 96 Vietnamese parents of unvaccinated adolescents to receive 0 to 4 HERO components. The study team will establish the feasibility (reach, retention, adherence) and acceptability (usability, satisfaction, usefulness, cultural relevance) of each component (expert video, self-persuasion, narrative storytelling, and motivational interviewing).

SECONDARY AIM To investigate effects of each component on HPV vaccination outcomes and psychosocial mediators. The study team will examine the effects on HPV vaccination (initiation and intention) and psychosocial mediators.

Who Is on the Research Team?

MV

Milkie Vu, PhD

Principal Investigator

Northwestern University

NK

Namratha Kandula

Principal Investigator

Northwestern University

SP

Siobhan Phillips

Principal Investigator

Northwestern University

JS

Juned Siddique

Principal Investigator

Northwestern University

Are You a Good Fit for This Trial?

This trial is for Vietnamese parents in the U.S. who have adolescents that have not yet received the HPV vaccine. Participants should be willing to try digital interventions aimed at encouraging vaccination.

Inclusion Criteria

Self-identify as U.S. Vietnamese
I am the only parent in my household of a 9-18 year old who hasn't started HPV vaccination.
Have lived in the U.S. for 12 months or more

Exclusion Criteria

Planning to move out of the U.S. within the next 6 months
Not fluent in either spoken and written Vietnamese or spoken and written English
I am unable to understand or agree to participate in this study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2 weeks
Online screener and potential brief Zoom, telephone, or in-person interview

Baseline Assessment and Randomization

Participants complete baseline assessments and are randomized to receive 0 to 4 intervention components

1 week
1 visit (virtual or in-person)

Intervention

Participants receive the constant component and 0 to 4 intervention components, completing them within 4 weeks

4 weeks
Online and phone/Zoom interactions

Follow-up

Participants are monitored for safety and effectiveness after treatment, with assessments at 1, 3, and 6 months post-baseline

6 months
3 follow-up assessments (1-month, 3-month, and 6-month post-randomization)

What Are the Treatments Tested in This Trial?

Interventions

  • Expert Video
  • Motivational Interviewing
  • Narrative Storytelling
  • Self-persuasion

Trial Overview

The study tests four different digital approaches—expert video, self-persuasion, storytelling, and motivational interviewing—to see which best encourages HPV vaccination among Vietnamese families. Parents are randomly assigned to receive any combination of these methods.

How Is the Trial Designed?

16

Treatment groups

Experimental Treatment

Group I: Experimental: Exp Condition 9Experimental Treatment4 Interventions
Group II: Experimental: Exp Condition 8Experimental Treatment2 Interventions
Group III: Experimental: Exp Condition 7Experimental Treatment3 Interventions
Group IV: Experimental: Exp Condition 6Experimental Treatment3 Interventions
Group V: Experimental: Exp Condition 5Experimental Treatment4 Interventions
Group VI: Experimental: Exp Condition 4Experimental Treatment3 Interventions
Group VII: Experimental: Exp Condition 3Experimental Treatment4 Interventions
Group VIII: Experimental: Exp Condition 2Experimental Treatment4 Interventions
Group IX: Experimental: Exp Condition 16Experimental Treatment1 Intervention
Group X: Experimental: Exp Condition 15Experimental Treatment2 Interventions
Group XI: Experimental: Exp Condition 14Experimental Treatment2 Interventions
Group XII: Experimental: Exp Condition 13Experimental Treatment3 Interventions
Group XIII: Experimental: Exp Condition 12Experimental Treatment2 Interventions
Group XIV: Experimental: Exp Condition 11Experimental Treatment3 Interventions
Group XV: Experimental: Exp Condition 10Experimental Treatment3 Interventions
Group XVI: Experimental: Exp Condition 1Experimental Treatment5 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Northwestern University

Lead Sponsor

Trials
1,674
Recruited
989,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

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