Ulonivirine + Methadone Interaction Study
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is designed to determine the effect of ulonivirine (MK-8507) on methadone in the body. Participants will take methadone alone and then methadone with ulonivirine to see if ulonivirine changes how the body processes methadone.
Who Is on the Research Team?
Medical Director
Principal Investigator
Merck Sharp & Dohme LLC
Are You a Good Fit for This Trial?
This trial is for healthy adults who have been on a stable dose of methadone as part of a maintenance program for at least two months, with a BMI between 18 and 40. Participants must be in good overall health.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study tests whether taking ulonivirine (MK-8507) changes how the body processes methadone. Participants first take methadone alone, then together with ulonivirine to compare effects.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants receive a stable dose of methadone orally from Day -14 through Day 16. Methadone is co-administered with one dose of oral ulonivirine on Day 2.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Merck Sharp & Dohme LLC
Lead Sponsor
Chirfi Guindo
Merck Sharp & Dohme LLC
Chief Marketing Officer since 2022
Degree in Engineering from Ecole Centrale de Paris, MBA from New York University Stern School of Business
Robert M. Davis
Merck Sharp & Dohme LLC
Chief Executive Officer since 2021
JD from Northwestern University Pritzker School of Law, MBA from Northwestern University Kellogg Graduate School of Management, Bachelor's in Finance from Miami University
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