Zegerid

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 15 more

Treatment

15 FDA approvals

20 Active Studies for Zegerid

What is Zegerid

Omeprazole

The Generic name of this drug

Treatment Summary

Magnesium hydroxide is a naturally occurring mineral that is used in a variety of ways. It can be taken orally as a liquid suspension or chewable tablet to act as an antacid or laxative. It is also used commercially as a fire retardant due to its smoke suppressing and flame retardant properties. Magnesium hydroxide can also be applied directly to the skin to act as a deodorant or to treat canker sores.

Prilosec

is the brand name

image of different drug pills on a surface

Zegerid Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Prilosec

Omeprazole

1990

669

Approved as Treatment by the FDA

Omeprazole, otherwise called Prilosec, is approved by the FDA for 15 uses which include multiple endocrine adenomas and Healing .

multiple endocrine adenomas

Healing

Gastro-esophageal Reflux Disease (GERD)

Gastric Ulcer

Gastroesophageal Reflux

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

Heartburn

Helps manage Heartburn

Stomach Ulcer

Duodenal Ulcer

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Heartburn

Helps manage Heartburn

Heartburn

Erosive Esophagitis

Adenoma

Curling Ulcer

Effectiveness

How Zegerid Affects Patients

Magnesium hydroxide is an antacid, meaning it reduces stomach acid by reacting with hydrochloric acid in the stomach. This reaction forms magnesium chloride and water, which helps to reduce irritation in the stomach, raise the pH level, and stop pepsin from working. Magnesium hydroxide also strengthens the barrier between the stomach and esophagus, as well as improving the strength of the muscles that control the stomach and esophagus. As a laxative, magnesium hydroxide increases the amount of water in the intestines, causing the colon to expand and leading to increased movement in the digestive system and eventually evacuation of

How Zegerid works in the body

Magnesium hydroxide helps to neutralize stomach acid when taken in small doses. If taken in larger doses, it acts as a laxative. The magnesium hydroxide combines with stomach acid to form magnesium chloride and water, which helps to reduce stomach acidity. When taken in larger doses, it can draw water into the intestines, softening stools and increasing intestinal motility, which stimulates the urge to have a bowel movement. Magnesium hydroxide can also release a hormone called cholecystokinin, which helps the intestines absorb more water and electrolytes.

When to interrupt dosage

The degree of Zegerid is contingent upon the determined diagnosis, including Acid indigestion, Upset stomach and Antacid therapy. The quantity of dosage is dependent upon the mode of administration stated in the table below.

Condition

Dosage

Administration

hypersecretory conditions

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Ankylosing Spondylitis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Heartburn

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Heartburn

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Rheumatoid Arthritis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Gastroesophageal Reflux

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Prophylaxis of NSAID gastric ulceration

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Mastocytosis, Systemic

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Stomach Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Helicobacter Pylori Infection

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Osteoarthritis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Zollinger-Ellison Syndrome

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Curling Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Adenoma

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Erosive Esophagitis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Stomach Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Healing

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Peptic Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Powder, for suspension, Granule, delayed release, Granule, delayed release - Oral, Powder, for suspension - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, film coated, Tablet, film coated - Oral, Kit, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Kit - Oral, For suspension - Oral, For suspension

Warnings

Zegerid Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Omeprazole may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Omeprazole may interact with Pulse Frequency

There are 20 known major drug interactions with Zegerid.

Common Zegerid Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Omeprazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Omeprazole.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Omeprazole.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Omeprazole.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Omeprazole.

Zegerid Toxicity & Overdose Risk

The toxic dose of magnesium hydroxide in rats is 8500mg/kg. Common side effects include drowsiness and feeling flushed. If taken daily, it can cause changes in fluid and electrolyte levels. Taking too much may cause abdominal cramping, nausea, and/or diarrhea. Symptoms of overdose include gastrointestinal irritation, watery diarrhea, nausea, vomiting, feeling flushed, thirst, low blood pressure, confusion, weak muscles, slowed breathing, irregular heartbeat, coma, and cardiac arrest. It should not be used if someone has kidney disease or a magnesium restricted diet, sudden changes in bowel movements lasting over two weeks, abdominal pain

image of a doctor in a lab doing drug, clinical research

Zegerid Novel Uses: Which Conditions Have a Clinical Trial Featuring Zegerid?

Presently, 43 active studies are assessing the potential of Zegerid to attenuate Gastric Acid Suppression, Flatulence and Acid Indigestion.

Condition

Clinical Trials

Trial Phases

Rheumatoid Arthritis

63 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Heartburn

15 Actively Recruiting

Phase 3, Not Applicable, Phase 4, Phase 2

Gastroesophageal Reflux

0 Actively Recruiting

Prophylaxis of NSAID gastric ulceration

0 Actively Recruiting

Mastocytosis, Systemic

0 Actively Recruiting

hypersecretory conditions

0 Actively Recruiting

Stomach Ulcer

2 Actively Recruiting

Phase 4, Not Applicable

Erosive Esophagitis

0 Actively Recruiting

Helicobacter Pylori Infection

1 Actively Recruiting

Not Applicable

Ankylosing Spondylitis

3 Actively Recruiting

Not Applicable, Phase 2

Stomach Ulcer

0 Actively Recruiting

Heartburn

3 Actively Recruiting

Phase 3, Not Applicable

Zollinger-Ellison Syndrome

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

Peptic Ulcer

0 Actively Recruiting

Adenoma

0 Actively Recruiting

Healing

0 Actively Recruiting

Zegerid Reviews: What are patients saying about Zegerid?

5

Patient Review

7/31/2012

Zegerid for Medication Treatment for Healing Erosive Esophagitis

I experienced some drowsiness while taking this medication, which was alleviated by running in the mornings. Otherwise, it did a great job at relieving my sensitive stomach and food allergies.

5

Patient Review

2/2/2012

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

This treatment has been extremely effective for me, though I have experienced some negative side effects like swollen ankles due to the high sodium content.

5

Patient Review

7/2/2011

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

My Gastro had me on every prescribe medication. Then He decided to try this. As I as well had surgery to try and control the acid reflux problem, which did help) But Zegerid in the powder form worked best for me. Some side effects but it is worth it. This is the FIRST time I have remarked on any medication.But again for what ever reason the pills where not effctive as well as the powder form for me. And it is instant relief within mins.

5

Patient Review

11/1/2011

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

This didn't work for me, unfortunately.

5

Patient Review

12/27/2011

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication has done wonders for my son who suffers from GERD. He used to be in a lot of pain, and would even choke sometimes. Now he's practically symptom-free and it's made such a difference in his quality of life.

5

Patient Review

12/26/2013

Zegerid for Conditions of Excess Stomach Acid Secretion

I was struggling with GERDs and tried a bunch of different meds that didn't help at all. A friend recommended this one, and I'm so glad they did! It's by far the best medication I've tried—I don't even get breakthrough symptoms anymore.

5

Patient Review

7/25/2015

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

I cannot stress enough how much this has helped me. I was struggling with gastroparesis and GERD for years, and nothing the doctors gave me ever worked. But Zegerid? Zegerid is a life saver.

5

Patient Review

4/12/2014

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

This is the only medication that works for my GERD. No side effects to speak of. Slightly pricey...but so is an ER visit.

5

Patient Review

5/12/2016

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking Zegrid for a long time to manage my stomach acid. I've tried other proton pump inhibitors, but I always come back to this one because it's the most effective.

5

Patient Review

11/28/2015

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

This treatment is really effective. I've tried other things like Prilosec, but this is by far the best.

4.7

Patient Review

5/24/2011

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

4.7

Patient Review

4/20/2012

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

Zegrid has been an absolute lifesaver for me. I can now eat and drink things that were previously off limits due to my acid reflux. It's amazing how much this medication has improved my quality of life.

3

Patient Review

9/23/2013

Zegerid for Conditions of Excess Stomach Acid Secretion

I'm really surprised at how quickly Zegerid worked.

2.7

Patient Review

8/24/2011

Zegerid for Condition in which Stomach Acid is Pushed Into the Esophagus

This provided some relief, which was good.

2.3

Patient Review

10/16/2011

Zegerid for Conditions of Excess Stomach Acid Secretion

After taking Zegrid for two days, I started feeling awful. I had fatigue, body aches, headaches, and nausea. So, I stopped taking it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zegerid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between Zegerid and Prilosec?

"Both Zegerid and Prilosec contain PPIs, but Zegerid also has an antacid. You can get Prilosec OTC or as a generic, and side effects for both drugs can include headache, stomach/abdominal pain, nausea, gas, and diarrhea."

Answered by AI

Which is better Nexium or Zegerid?

"Nexium works to relieve heartburn better than other antacids, but there are some risks associated with long-term use. Most people can take Zegerid without any noticeable side effects. Zegerid lasts longer than other types of antacids, so you may only need to take it once a day."

Answered by AI

What is Zegerid used for?

"Zegerid OTC is a heartburn medication that contains the proton pump inhibitor omeprazole. It is used to treat frequent heartburn, which is defined as heartburn occurring two or more days per week. Omeprazole works by reducing acid production, which relieves heartburn symptoms."

Answered by AI

Is Zegerid the same as Zantac?

"Zegerid and Zantac are both used to treat stomach problems, but they work in different ways. Zegerid is a combination of a proton-pump inhibitor (PPI) and an antacid, while Zantac is an H2 (histamine-2) receptor blocker. Both drugs can cause side effects such as headache, stomach or abdominal pain, nausea, and diarrhea."

Answered by AI

Clinical Trials for Zegerid

Image of Northwestern Medicine Rheumatology in Chicago, United States.

Patient-Reported Outcomes Dashboard for Inflammatory Arthritis

18+
All Sexes
Chicago, IL

The goal of this clinical trial is to learn whether showing patient-reported symptoms and personal treatment goals to rheumatology clinicians on a dashboard in the electronic health record improves shared decision-making for adults with rheumatoid arthritis or psoriatic arthritis. The main questions it aims to answer are: * Do patients whose clinicians use the dashboard report more shared decision-making during their rheumatology visits than patients who receive usual care? * Do patients in the dashboard group report greater progress toward their personal goals and more confidence in managing their symptoms after 6 months? Researchers will compare the dashboard group to a usual care group to see if the dashboard improves shared decision-making, goal attainment, and self-efficacy. Participants will: * Complete a routine symptom questionnaire before their rheumatology visits, as all clinic patients do * Choose personal treatment goals and rate their progress toward those goals 6 months later * Complete short surveys before and after two rheumatology visits about 6 months apart Participants in the dashboard group will also complete questionnaires in the patient portal about pain, fatigue, physical function, sleep, and morning stiffness before each visit. Their answers and goals will be shown to their clinician on a dashboard to guide the conversation during the visit.

Waitlist Available
Has No Placebo

Northwestern Medicine Rheumatology

Have you considered Zegerid clinical trials?

We made a collection of clinical trials featuring Zegerid, we think they might fit your search criteria.
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Image of Tidal Health in Salisbury, United States.

Fortiskap for Medication Adherence

18+
All Sexes
Salisbury, MD

Medication non-adherence is associated with greater morbidity and mortality in chronic disease, and has been estimated to increase healthcare costs by over $170 billion annually in the United States.1 Medication adherence is challenging for patients across the spectrum of medical disorders that are treated with long-term use of oral medications. Poor medication adherence can result in increased risk of complications, disease progression, increased healthcare utilization and poor therapeutic outcomes.2 Adherence is typically tracked using measures based on pharmacy fill data such as the medication possession ratio (MPR) and/or proportion of days covered (PDC).3 Although MPR and PDC are associated with a higher likelihood of using medication as prescribed at the population level, when compared to direct assessments or patient reports, they are not accurate enough for making individual management decisions and likely to underestimate non-adherence.4 However, real-time documentation methods using direct video observation are expensive and cumbersome for patients and providers. Gastroesophageal reflux disease (GERD) is among the most prevalent gastrointestinal conditions in the United States, affecting an estimated 20-30% of the adult population.5 Proton pump inhibitors (PPIs) are the cornerstone of pharmacologic management for GERD forming the standard of care for erosive esophagitis, Barrett's esophagus, and symptomatic non-erosive reflux disease.6 Despite their established efficacy, suboptimal medication adherence remains a significant clinical barrier: estimates of PPI adherence in real-world populations range from 50-70% at one year7, with non-adherence associated with symptom recurrence, mucosal injury, and increased healthcare utilization.8 FORTISKAP™ (Cosmos Rx, Inc.) is a digital adherence monitoring device consisting of a sensor-embedded cap that attaches to standard prescription medication bottles. The device records the date and time of each bottle opening event and transmits this data wirelessly to a paired smartphone application, which generates adherence metrics and patient-facing reminders. Prescribers may access aggregated adherence data through a connected provider portal. The goal of this study is to demonstrate that the Fortiskap™ prescription bottle-top, medication adherence device results in a higher detection rate of medication non-adherence compared to pharmacy fill-data assessment and/or compared to ARMS adherence self-assessment.

Waitlist Available
Has No Placebo

Tidal Health

Abraham N Morse, MD, MBA

Cosmos Rx, Inc

Image of Cleveland Clinic in Cleveland, United States.

Antireflux Surgery for Acid Reflux

18+
All Sexes
Cleveland, OH

The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia. Manometry measures the muscles of the food pipe using a thin tube passed through the nose. The test can be uncomfortable and can delay surgery. The main questions this study aims to answer are whether people can skip manometry and still have good swallowing one year after surgery, and whether skipping the test lowers discomfort, shortens the wait for surgery, and lowers cost. To answer this, researchers will compare two groups. One group will have surgery without manometry. The other group will have manometry first, the way it is usually done. Everyone will get the same operation, a partial wrap called a Toupet fundoplication, so the study tests the value of the test and not the surgery. Participants will be placed by chance into one of the two groups, have the same standard operation, and fill out short questionnaires about their swallowing before surgery and again at 3, 6, and 12 months after surgery. Researchers want to find out if skipping manometry works just as well as the usual approach for people who do not have trouble swallowing before surgery.

Waitlist Available
Has No Placebo

Cleveland Clinic (+1 Sites)

Image of University of Oklahoma Health Campus in Oklahoma City, United States.

Disulfiram for Rheumatoid Arthritis

18 - 75
All Sexes
Oklahoma City, OK

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation. Obesity is common among individuals with RA and is associated with increased disease activity, reduced treatment response, and worse functional outcomes. Inflammation in adipose tissue, driven in part by activation of the NLRP3 inflammasome and downstream gasdermin D (GSDMD)-mediated pathways, may contribute to systemic inflammation and RA disease severity. Disulfiram (DSF), an FDA-approved medication for alcohol use disorder, has recently been identified as an inhibitor of GSDMD-mediated inflammatory signaling and pyroptosis. Preclinical studies suggest that DSF reduces inflammasome activation, inflammatory cytokine release, and metabolic dysfunction. This study is a 12-week, randomized, double-blind, placebo-controlled pilot trial designed to evaluate the safety, tolerability, and preliminary efficacy of DSF in overweight and obese adults with active RA despite stable disease-modifying antirheumatic drug (DMARD) therapy. Participants will be randomized to receive either DSF (250 mg daily) or placebo. The primary objective is to assess safety and tolerability. Secondary and exploratory objectives include evaluating the effects of DSF on systemic inflammation, RA disease activity, metabolic parameters, and adipose tissue inflammasome activation. Findings from this study will inform the feasibility and design of larger clinical trials targeting GSDMD-mediated inflammation in RA.

Phase 2
Waitlist Available

University of Oklahoma Health Campus

Beatriz Y Hanaoka, MD, MSc

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Ketogenic and Carnivore Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis

18 - 64
All Sexes
Charlottesville, VA

This study is a randomized controlled clinical trial evaluating whether two therapeutic dietary approaches - a ketogenic diet and a carnivore (lion) diet - can improve quality of life, reduce symptoms, and influence measures of disease activity in adults with inflammatory bowel disease \[ulcerative colitis and Crohn's disease\] (IBD) or rheumatoid arthritis (RA). Participants will be randomized into one of three groups: 1) Ketogenic Diet, 2) Carnivore (Lion) Diet or 3) Wait-List Control. Participants randomized to a dietary group (ketogenic diet or carnivore diet) will be provided guidance on their specific dietary therapy and answer questions about their symptoms and quality of life at different intervals over a 24 week period. Participants will also complete laboratory testing at different intervals to assess for changes in nutritional status, cardiometabolic health and markers of immune activation and inflammation. Participants initially placed on the wait-list group will be asked similar questions about their symptoms and quality of life and complete the same laboratory testing as participants in a dietary group. Participants on the wait list will then be compared to participants following a specific dietary pattern to assess for any differences between the 2 groups. After 12 weeks, participants on the wait list will be randomized to a dietary group (ketogenic diet or carnivore diet) and followed in a similar fashion for an additional 12 week period.

Recruiting
Has No Placebo

Resilient Roots: Functional Medicine

Robert D Abbott, MD

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