Cimetidine Excretion During Lactation

This trial aims to study how the drug cimetidine is processed and excreted in breast milk. Researchers seek to understand the activity of certain proteins in the mammary glands of healthy breastfeeding women. The study is recruiting healthy postpartum women who are not currently taking cimetidine or other medications that might interact with it. Participants will provide important insights into the safety and effects of drugs during lactation. As a Phase 4 trial, this research focuses on an FDA-approved treatment to understand its benefits for more patients, offering participants a chance to contribute to safer medication use during breastfeeding.

Yes, you may need to stop taking certain medications. The trial excludes participants taking medications that interact with cimetidine or affect specific drug transporters. It's best to discuss your current medications with the trial team to see if any need to be stopped.

Research has shown that cimetidine is generally safe for breastfeeding mothers and their babies. Studies have found that only a small amount of cimetidine passes into breast milk, and no side effects have been reported in breastfed babies, particularly those older than two months.

A breastfeeding baby would receive about 6.7% of the cimetidine dose taken by the mother. This small amount is not expected to cause harm. Among over-the-counter heartburn medications, cimetidine is considered safe for breastfeeding mothers.

Researchers are excited about studying cimetidine excretion during lactation because it aims to provide crucial insights into how this medication transfers into breast milk. Unlike other treatments that focus on the direct therapeutic effects of drugs, this study focuses on understanding drug safety and exposure for breastfeeding infants. By exploring how much cimetidine is excreted into breast milk, the trial can help guide safer medication use for nursing mothers, potentially impacting prescribing practices and enhancing infant safety.

Previous studies have shown that cimetidine effectively treats heartburn and ulcers by reducing stomach acid. Research indicates that cimetidine blocks certain signals in the stomach, lowering acid levels. Although this trial does not focus on treating a specific condition, it aims to understand how cimetidine enters breast milk and how the body processes it during breastfeeding. The study will involve healthy lactating women to help ensure the safe use of cimetidine for breastfeeding mothers. Overall, cimetidine has a proven history of effectively reducing stomach acid.