Vecuronium Bromide

Intubation (procedure), Intubation (procedure), General Anesthesia + 1 more

Treatment

4 FDA approvals

2 Active Studies for Vecuronium Bromide

What is Vecuronium Bromide

Vecuronium

The Generic name of this drug

Treatment Summary

Vecuronium is a muscle relaxant used to temporarily weaken muscles during surgery. It is a type of non-depolarizing neuromuscular blocking agent that has a shorter duration of action than other similar drugs. Vecuronium is preferred to other muscle relaxants due to its minimal cardiovascular side effects, short duration of action, and the fact that it does not need to be eliminated by the kidneys.

Norcuron

is the brand name

image of different drug pills on a surface

Vecuronium Bromide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Norcuron

Vecuronium

1984

38

Approved as Treatment by the FDA

Vecuronium, also known as Norcuron, is approved by the FDA for 4 uses such as Intubation (procedure) and Therapeutic procedure .

Intubation (procedure)

Therapeutic procedure

Intubation (procedure)

General Anesthesia

Used in combination with other therapies

Effectiveness

How Vecuronium Bromide Affects Patients

Vecuronium is used to relax muscles during medical procedures. It works by blocking certain nerve signals from reaching the muscles, which causes them to relax.

How Vecuronium Bromide works in the body

Vecuronium blocks the transmission of nerve signals to muscles, preventing them from contracting. It does this by competing with acetylcholine for binding to special receptors on the surface of nerve cells. When vecuronium binds to these receptors, it prevents the release of calcium ions, which are necessary for muscle contraction.

When to interrupt dosage

The amount of Vecuronium Bromide hinges on the indicated condition, such as Intubation (procedure), Intubation (procedure) and smooth muscle relaxation prior to radiological procedures. The dose also differs as per the technique of delivery (e.g. Intravenous or Powder, for solution) delineated in the table beneath.

Condition

Dosage

Administration

General Anesthesia

, 1.0 mg/mL, 2.0 mg/mL, 10.0 mg, 20.0 mg, 5.0 mg/mL

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Intubation (procedure)

, 1.0 mg/mL, 2.0 mg/mL, 10.0 mg, 20.0 mg, 5.0 mg/mL

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Intubation (procedure)

, 1.0 mg/mL, 2.0 mg/mL, 10.0 mg, 20.0 mg, 5.0 mg/mL

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Therapeutic procedure

, 1.0 mg/mL, 2.0 mg/mL, 10.0 mg, 20.0 mg, 5.0 mg/mL

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Warnings

There are 20 known major drug interactions with Vecuronium Bromide.

Common Vecuronium Bromide Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Vecuronium may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Eluxadoline

Major

The risk or severity of constipation can be increased when Vecuronium is combined with Eluxadoline.

Ethanol

Major

Vecuronium may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Vecuronium is combined with Oliceridine.

Secretin human

Major

The therapeutic efficacy of Secretin human can be decreased when used in combination with Vecuronium.

image of a doctor in a lab doing drug, clinical research

Vecuronium Bromide Novel Uses: Which Conditions Have a Clinical Trial Featuring Vecuronium Bromide?

4 active studies are currently assessing the potential of Vecuronium Bromide for providing smooth muscle relaxation prior to radiological procedures, General Anesthesia and Intubation.

Condition

Clinical Trials

Trial Phases

Intubation (procedure)

0 Actively Recruiting

Intubation (procedure)

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

General Anesthesia

2 Actively Recruiting

Phase 4, Not Applicable

Vecuronium Bromide Reviews: What are patients saying about Vecuronium Bromide?

1

Patient Review

10/22/2008

Vecuronium Bromide for Additional Agent to Induce General Anesthesia

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about vecuronium bromide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What would vecuronium be used for?

"This drug, which causes muscle paralysis, is often used to help with putting a tube down a patient's throat and making them relaxed during surgery when they are under general anesthesia."

Answered by AI

What is vecuronium made from?

"The vial contains 20 mg of Vecuronium bromide, 41.5 mg citric acid anhydrous, 32.5 mg dibasic sodium phosphate anhydrous, 194 mg mannitol, sodium hydroxide and/or phosphoric acid to buffer and adjust to a pH range of 3.5 to 4.5."

Answered by AI

What does vecuronium bromide do?

"Vecuronium bromide can be used to help with anesthesia, making it easier to put a tube down someone's throat and also providing muscle relaxation during surgery or when a machine is helping them breathe."

Answered by AI

What is another name for vecuronium?

"Vecuronium is a prescription medication that is used as general anesthesia. Vecuronium is available from various brands, such as Norcuron."

Answered by AI

Clinical Trials for Vecuronium Bromide

Image of Mount Sinai Hospital in Toronto, Canada.

Intubation Blades for C-Section

Any Age
Female
Toronto, Canada

Cesarean section under general anesthesia requires intubation (insertion of a tube through the mouth into the breathing pipe to support breathing during the surgery). A device called a video laryngoscope is used, which has a smooth, curved, or less curved component called 'a blade' that helps the doctor gently see the voice box and guide the breathing tube safely into place during anesthesia; it is not a sharp tool blade. There are two types of video laryngoscopes blades: a Macintosh- style blade with a gentle curve, approximately 90 degrees) and a hyperangulated blade (with a more pronounced curve). Although video laryngoscopes are safe and both types have been used for around 20 years, it is not known whether one type works better that the other in patients undergoing cesarean delivery under general anesthesia. Because general anesthesia is used in only a small proportion (about 5%) of all cesarean deliveries, research in this area is limited. The main purpose of the study is to assess if a study comparing these two types of blades in the obstetric population is feasible. This is also known as a feasibility study, which aims to test the study plan and determine whether enough participants will join a larger study and accept the study procedures. The results will be used as a guide for a larger study.

Waitlist Available
Has No Placebo

Mount Sinai Hospital