Protopic

Vitiligo, Pyoderma Gangrenosum, Kidney Transplantation + 12 more

Treatment

5 FDA approvals

20 Active Studies for Protopic

What is Protopic

Tacrolimus

The Generic name of this drug

Treatment Summary

Tacrolimus is a drug used to suppress the immune system in order to prevent organ rejection after transplant surgery. It can also be used to treat severe atopic dermatitis, a type of skin condition, and vitiligo, a condition where the skin loses its color. Tacrolimus works by binding to an immunophilin called FKBP-12, which switches off a protein called calcineurin and stops T-lymphocyte cells from sending signals that cause inflammation. Tacrolimus was discovered in 1984 from a Japanese soil sample containing the bacteria Streptomyces tsukubaensis.

Prograf

is the brand name

image of different drug pills on a surface

Protopic Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Prograf

Tacrolimus

1994

138

Approved as Treatment by the FDA

Tacrolimus, also called Prograf, is approved by the FDA for 5 uses such as Liver Transplant Rejection and Kidney Transplantation .

Liver Transplant Rejection

Kidney Transplantation

Kidney Transplant Rejection

Immunosuppressive Treatment

Kidney

Effectiveness

How Protopic Affects Patients

Tacrolimus works by attaching to a protein called FKBP-12, which stops the body from sending signals that cause inflammation. It is similar to another drug called cyclosporine, but has been shown to be more effective in preventing rejection of transplanted organs. Tacrolimus is also used to treat eczema, especially atopic eczema, as it suppresses inflammation like steroids but is not as strong. In addition, tacrolimus can be used directly on the face while topical steroids should not be used there since they can thin the skin. For other parts of the body though, topical steroids

How Protopic works in the body

We don't know exactly how tacrolimus works to treat atopic dermatitis. But, it appears to prevent cells from creating proteins that cause inflammation. Tacrolimus binds to a protein inside cells and stops them from producing molecules like interleukin-3, interleukin-4, interleukin-5, GM-CSF, and TNF-, which are all related to inflammation. Tacrolimus also stops mast cells and basophils from releasing substances that cause inflammation and it reduces the expression of a protein on Langerhans cells that helps cause inflammation.

When to interrupt dosage

The prescribed dosage of Protopic is contingent upon the confirmed affliction, including Vitiligo, Rejection; Transplant, Kidney and Pyoderma Gangrenosum. The measure of dosage is contingent upon the technique of delivery (e.g. Capsule, gelatin coated - Oral or Topical) as observed in the table underneath.

Condition

Dosage

Administration

Dermatitis, Atopic

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Rheumatoid Arthritis

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Lichen Planus, Oral

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Chronic Graft Versus Host Disease

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Lung

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Psoriasis

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Pyoderma Gangrenosum

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Liver

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Dermatitis, Atopic

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Immunocompromised

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Vitiligo

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Kidney Transplantation

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Prophylaxis against heart transplant rejection

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Kidney

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Immunosuppressive Treatment

0.5 mg, , 1.0 mg, 5.0 mg, 0.001 mg/mg, 0.0003 mg/mg, 4.0 mg, 0.75 mg, 3.0 mg, 0.2 mg, 0.03 %, 0.1 %, 5.0 mg/mL, 5.0 mg/mg, 0.00003 mg/mg, 0.003 mg/mg

Oral, Capsule, , Capsule - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Topical, Ointment - Topical, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Solution, Intravenous, Solution - Intravenous, Capsule, extended release - Oral, Granule, Granule - Oral, Ointment, Cutaneous, Ointment - Cutaneous, Injection, solution - Intravenous, Injection, solution, Capsule, extended release, Tablet, extended release - Oral, Tablet, extended release, Granule, for suspension, Granule, for suspension - Oral, Cream - Topical, Cream, Solution - Topical, Kit

Warnings

Protopic Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Tacrolimus may interact with Pulse Frequency

There are 20 known major drug interactions with Protopic.

Common Protopic Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Tacrolimus.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Tacrolimus.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Tacrolimus.

Axitinib

Major

The serum concentration of Axitinib can be increased when it is combined with Tacrolimus.

Bacillus calmette-guerin substrain russian BCG-I live antigen

Major

The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Tacrolimus.

Protopic Toxicity & Overdose Risk

Taking too much of this drug can lead to blurred vision, liver and kidney damage, seizures, shaking, high blood pressure, low magnesium levels, diabetes, high potassium levels, itching, difficulty sleeping, and disorientation. The lowest toxic dose in rats has been found to be between 134 and 194 mg/kg.

image of a doctor in a lab doing drug, clinical research

Protopic Novel Uses: Which Conditions Have a Clinical Trial Featuring Protopic?

147 active trials are currently being conducted to assess the potential of Protopic for Oral Lichen Planus, Pyoderma Gangrenosum and refractory Rheumatoid Arthritis management.

Condition

Clinical Trials

Trial Phases

Pyoderma Gangrenosum

4 Actively Recruiting

Phase 2, Phase 3

Rheumatoid Arthritis

63 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Immunocompromised

3 Actively Recruiting

Phase 1, Phase 3, Not Applicable

Lichen Planus, Oral

0 Actively Recruiting

Vitiligo

6 Actively Recruiting

Phase 2, Phase 3, Phase 1

Kidney Transplantation

0 Actively Recruiting

Kidney

0 Actively Recruiting

Liver

0 Actively Recruiting

Immunosuppressive Treatment

0 Actively Recruiting

Lung

0 Actively Recruiting

Dermatitis, Atopic

0 Actively Recruiting

Prophylaxis against heart transplant rejection

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

Chronic Graft Versus Host Disease

26 Actively Recruiting

Phase 4, Phase 1, Phase 2, Not Applicable, Phase 3

Dermatitis, Atopic

0 Actively Recruiting

Protopic Reviews: What are patients saying about Protopic?

5

Patient Review

4/20/2015

Protopic for Eczema Skin Condition Resisting Treatment

I had mixed results with this medication. At first, it seemed to help my eyelids, but then I developed large sores on my lips. This is a serious side effect that you should be aware of before using the medication.

5

Patient Review

9/1/2014

Protopic for Eczema Skin Condition Resisting Treatment

I haven't seen any benefits from using this medication.

5

Patient Review

1/5/2016

Protopic for Eczema Skin Condition Resisting Treatment

So far, this has worked great for my psoriasis. I was instructed to use it every night until my skin clears up and then twice a week for maintenance. After just two uses, the itchiness, flakiness, and redness were gone. I'm looking forward to seeing how well it works in the long term.

5

Patient Review

8/20/2020

Protopic for Atopic Dermatitis

This is the only medication that has ever helped clear up my skin issue on my eyelids.

4.3

Patient Review

1/25/2016

Protopic for Atopic Dermatitis

I started developing eczema around my eyes when I was fourteen. After trying a few different products, this one finally gave me the relief I needed. It burns a little bit at first, but it's definitely worth it!

4

Patient Review

6/2/2015

Protopic for Eczema Skin Condition Resisting Treatment

I had eczema as a kid and it started flaring up again around my nose, mouth, and eyelids when I turned 30. I tried everything from lanolin ointment to steroid ointments without any relief for months. But after just three days of using this treatment (twice a day), my eczema was completely gone! It burns a little bit when you first put it on, but the results are more than worth it.

3.3

Patient Review

1/13/2015

Protopic for Atopic Dermatitis

We tried this treatment for my son's chronic eczema at the doctor's suggestion. While it looked like it was working at first, things quickly took a turn for the worse. He started getting headaches and sore throats, and also developed stomach aches and pains. We're stopping the medication now, and hopefully there won't be any lasting effects from such a short course of treatment.

3.3

Patient Review

7/22/2015

Protopic for Eczema Skin Condition Resisting Treatment

I get flare-ups on my eyelids, so bad that my eyes will almost completely swell shut. The first time I used it on my eyelids it burned and itched like fire. Gradually that went away (after a few hours) and after a day or so my the eczema was mostly gone.

2

Patient Review

11/27/2014

Protopic for Eczema Skin Condition Resisting Treatment

My teenage son uses this only on flare ups and it clears it after just a few days. I only use it once a day before bed and he hasn't had any side effects. I am afraid to use it on his face though, but some of your review state that it's ok??

2

Patient Review

9/30/2017

Protopic for Atopic Dermatitis

I've had eczema for over 30 years and have tried everything on the market. Protopic was the first thing that worked long-term, especially for my face. It can burn a little bit when you put it on, but that goes away after a few uses. This medication has been a lifesaver for me.

1

Patient Review

10/22/2022

Protopic for Eczema Skin Condition Resisting Treatment

Do not use this cream! I have had psoriasis for 14 years and recently tried this new cream. After only four days, I broke out in painful blisters that are spreading. It's behaving similarly to a second degree burn. Avoid at all costs.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about protopic

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is PROTOPIC Ointment used for?

"PROTOPIC Ointment is a prescription medicine used topically to treat eczema. It belongs to a class of medicines called topical calcineurin inhibitors and is for use in adults and children aged 2 years and older who do not have a weakened immune system."

Answered by AI

What are the side effects of Protopic?

"The side effects of this medication include a mild burning or stinging sensation, skin redness, acne, cold or flu symptoms (stuffy nose, sneezing, sore throat), headache, and increased sensitivity to hot or cold temperatures."

Answered by AI

Is Protopic safe for face?

"This ointment can be applied to any area of the body, except for mucous membranes, including the face, neck, and areas where the skin bends. It shouldn't be applied with an occlusive dressing because this method hasn't been studied in patients."

Answered by AI

Is Protopic a steroid cream?

"There are many treatments for eczema, but Protopic is different because it does not contain steroids. This means that it will not cause any of the side effects of topical steroids."

Answered by AI

Clinical Trials for Protopic

Image of Northwestern Medicine Rheumatology in Chicago, United States.

Patient-Reported Outcomes Dashboard for Inflammatory Arthritis

18+
All Sexes
Chicago, IL

The goal of this clinical trial is to learn whether showing patient-reported symptoms and personal treatment goals to rheumatology clinicians on a dashboard in the electronic health record improves shared decision-making for adults with rheumatoid arthritis or psoriatic arthritis. The main questions it aims to answer are: * Do patients whose clinicians use the dashboard report more shared decision-making during their rheumatology visits than patients who receive usual care? * Do patients in the dashboard group report greater progress toward their personal goals and more confidence in managing their symptoms after 6 months? Researchers will compare the dashboard group to a usual care group to see if the dashboard improves shared decision-making, goal attainment, and self-efficacy. Participants will: * Complete a routine symptom questionnaire before their rheumatology visits, as all clinic patients do * Choose personal treatment goals and rate their progress toward those goals 6 months later * Complete short surveys before and after two rheumatology visits about 6 months apart Participants in the dashboard group will also complete questionnaires in the patient portal about pain, fatigue, physical function, sleep, and morning stiffness before each visit. Their answers and goals will be shown to their clinician on a dashboard to guide the conversation during the visit.

Waitlist Available
Has No Placebo

Northwestern Medicine Rheumatology

Have you considered Protopic clinical trials?

We made a collection of clinical trials featuring Protopic, we think they might fit your search criteria.
Go to Trials

Have you considered Protopic clinical trials?

We made a collection of clinical trials featuring Protopic, we think they might fit your search criteria.
Go to Trials
Image of University of Oklahoma Health Campus in Oklahoma City, United States.

Disulfiram for Rheumatoid Arthritis

18 - 75
All Sexes
Oklahoma City, OK

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation. Obesity is common among individuals with RA and is associated with increased disease activity, reduced treatment response, and worse functional outcomes. Inflammation in adipose tissue, driven in part by activation of the NLRP3 inflammasome and downstream gasdermin D (GSDMD)-mediated pathways, may contribute to systemic inflammation and RA disease severity. Disulfiram (DSF), an FDA-approved medication for alcohol use disorder, has recently been identified as an inhibitor of GSDMD-mediated inflammatory signaling and pyroptosis. Preclinical studies suggest that DSF reduces inflammasome activation, inflammatory cytokine release, and metabolic dysfunction. This study is a 12-week, randomized, double-blind, placebo-controlled pilot trial designed to evaluate the safety, tolerability, and preliminary efficacy of DSF in overweight and obese adults with active RA despite stable disease-modifying antirheumatic drug (DMARD) therapy. Participants will be randomized to receive either DSF (250 mg daily) or placebo. The primary objective is to assess safety and tolerability. Secondary and exploratory objectives include evaluating the effects of DSF on systemic inflammation, RA disease activity, metabolic parameters, and adipose tissue inflammasome activation. Findings from this study will inform the feasibility and design of larger clinical trials targeting GSDMD-mediated inflammation in RA.

Phase 2
Waitlist Available

University of Oklahoma Health Campus

Beatriz Y Hanaoka, MD, MSc

Image of Hopital general de Montreal in Montreal, Canada.

Nurse-led Telehealth for Rheumatoid Arthritis

18+
All Sexes
Montreal, Canada

Canada urgently needs new ways to provide rheumatology care that improve treatment and make it easier for people to get high-quality care. E-health technology is a new and promising way to do this, but it hasn't been studied much yet in rheumatology. The investigators will test a new way to help people with rheumatoid arthritis at four clinics in Quebec. This study will check if the new approach is easy to use, fits well into the clinics' daily routine, and if both patients and healthcare workers find it helpful and acceptable. This new approach involves nurses helping patients check their own health from home using an online platform. 104 adults who have rheumatoid arthritis and who have had a flare-up or a change in their medication in the last three months, will participate. Some will start using the online self-monitoring tool right away for 16 months, while others will continue with their usual care for 8 months before trying the tool. During the time they use the tool, they will fill out monthly online questionnaires to check their health. A rheumatology nurse will review their answers, suggest any needed care, provide personalized health information, and be available to answer questions through messages. This new way of care, where nurses help patients monitor their rheumatoid arthritis from home, helps make better use of limited specialist time. It's more convenient for patients, especially those who live far away, and helps meet their needs between regular doctor visits while keeping the quality of care high.

Waitlist Available
Has No Placebo

Hopital general de Montreal (+3 Sites)

Laetitia Michou, MD PhD

Image of Resilient Roots: Functional Medicine in Charlottesville, United States.

Ketogenic and Carnivore Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis

18 - 64
All Sexes
Charlottesville, VA

This study is a randomized controlled clinical trial evaluating whether two therapeutic dietary approaches - a ketogenic diet and a carnivore (lion) diet - can improve quality of life, reduce symptoms, and influence measures of disease activity in adults with inflammatory bowel disease \[ulcerative colitis and Crohn's disease\] (IBD) or rheumatoid arthritis (RA). Participants will be randomized into one of three groups: 1) Ketogenic Diet, 2) Carnivore (Lion) Diet or 3) Wait-List Control. Participants randomized to a dietary group (ketogenic diet or carnivore diet) will be provided guidance on their specific dietary therapy and answer questions about their symptoms and quality of life at different intervals over a 24 week period. Participants will also complete laboratory testing at different intervals to assess for changes in nutritional status, cardiometabolic health and markers of immune activation and inflammation. Participants initially placed on the wait-list group will be asked similar questions about their symptoms and quality of life and complete the same laboratory testing as participants in a dietary group. Participants on the wait list will then be compared to participants following a specific dietary pattern to assess for any differences between the 2 groups. After 12 weeks, participants on the wait list will be randomized to a dietary group (ketogenic diet or carnivore diet) and followed in a similar fashion for an additional 12 week period.

Recruiting
Has No Placebo

Resilient Roots: Functional Medicine

Robert D Abbott, MD

Have you considered Protopic clinical trials?

We made a collection of clinical trials featuring Protopic, we think they might fit your search criteria.
Go to Trials