Promethazine Dm

Anaphylaxis, Catarrh, Acute Bronchitis + 18 more

Treatment

6 FDA approvals

20 Active Studies for Promethazine Dm

What is Promethazine Dm

Promethazine

The Generic name of this drug

Treatment Summary

Dextromethorphan is a medication used to reduce coughing. It is a derivative of codeine but does not have the same effects on opioid receptors as other opioids. Dextromethorphan was approved by the FDA in 1957 and is sometimes abused as a recreational drug.

Phenergan

is the brand name

image of different drug pills on a surface

Promethazine Dm Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Phenergan

Promethazine

1951

473

Approved as Treatment by the FDA

Promethazine, otherwise called Phenergan, is approved by the FDA for 6 uses such as Nasal Congestion and Acute Bronchitis .

Nasal Congestion

Used to treat Nasal Congestion in combination with Phenylephrine

Acute Bronchitis

Used to treat Cough in combination with Dextromethorphan

Hypersensitivity

Used to treat Allergic Reaction in combination with Codeine

Anaphylaxis

Catarrh

Used to treat Common Cold in combination with Codeine

upper respiratory symptoms

Used to treat upper respiratory symptoms in combination with Codeine

Effectiveness

How Promethazine Dm Affects Patients

Dextromethorphan is used together with other medicines to treat coughing and pseudobulbar affect. It is important to be careful with this drug, as taking too much can cause intoxication. The effects of dextromethorphan generally last for a moderate amount of time. Patients should be warned about the risk of taking too much of this medication.

How Promethazine Dm works in the body

Dextromethorphan works by activating and blocking certain receptors in the body. It activates NMDA and sigma-1 receptors, as well as blocking α3/β4 nicotinic receptors. Although it is not fully understood, this action is thought to have a beneficial effect on the body.

When to interrupt dosage

The portion of Promethazine Dm is relative to the determined condition, such as Coughing, Fever and Antisepsis. The amount of dosage fluctuates, in line with the method of delivery listed in the table below.

Condition

Dosage

Administration

Hypersensitivity

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Allergic urticaria

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Sedative therapy

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Allergic Conjunctivitis (AC)

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Postoperative Pain

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

upper respiratory symptoms

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Analgesics

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Hay Fever

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Coughing

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Nasal Congestion

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Motion Sickness

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Acute Bronchitis

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Nausea

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Dermographism

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

perioperative nausea and vomiting

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Airsickness

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Rhinitis, Vasomotor

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Anaphylaxis

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Hypersensitivity

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Catarrh

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Syrup, Syrup - Oral, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid - Oral, Liquid, Solution - Oral, Solution, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Cream, Cream - Topical, Capsule, Capsule - Oral, Topical

Warnings

Promethazine Dm has one contraindication and should not be utilized if you experience any of the circumstances listed in the following table.

Promethazine Dm Contraindications

Condition

Risk Level

Notes

subcutaneous route of administration

Do Not Combine

Asthma

Do Not Combine

Pulse Frequency

Do Not Combine

intra-arterial route of administration

Do Not Combine

Coma

Do Not Combine

lower respiratory tract symptoms

Do Not Combine

There are 20 known major drug interactions with Promethazine Dm.

Common Promethazine Dm Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Promethazine.

Aclidinium

Major

The risk or severity of adverse effects can be increased when Promethazine is combined with Aclidinium.

Amisulpride

Major

Promethazine may increase the antipsychotic activities of Amisulpride.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Promethazine.

Azelastine

Major

Promethazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Promethazine Dm Toxicity & Overdose Risk

An overdose of dextromethorphan may cause nausea, vomiting, loss of consciousness, slowed breathing, seizures, rapid heartbeat, confusion, hallucinations, unsteadiness, jerky eye movements, changes in reflexes, and serotonin syndrome. Treatment for overdose includes providing supportive care and symptom relief.

Promethazine Dm Novel Uses: Which Conditions Have a Clinical Trial Featuring Promethazine Dm?

134 active studies are underway to assess the potential of Promethazine Dm in providing relief from Influenza, Pseudobulbar Affect (PBA) and Coughing.

Condition

Clinical Trials

Trial Phases

Anaphylaxis

2 Actively Recruiting

Phase 1, Phase 2

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Motion Sickness

0 Actively Recruiting

Analgesics

1 Actively Recruiting

Phase 4

Catarrh

1 Actively Recruiting

Not Applicable

Nausea

0 Actively Recruiting

Dermographism

0 Actively Recruiting

Acute Bronchitis

6 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 4

upper respiratory symptoms

0 Actively Recruiting

Postoperative Pain

21 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1, Phase 3

Allergic urticaria

0 Actively Recruiting

perioperative nausea and vomiting

0 Actively Recruiting

Sedative therapy

0 Actively Recruiting

Pain management

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Hypersensitivity

1 Actively Recruiting

Phase 4

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 3

Hay Fever

0 Actively Recruiting

Hypersensitivity

0 Actively Recruiting

Airsickness

3 Actively Recruiting

Not Applicable, Phase 3

Promethazine Dm Reviews: What are patients saying about Promethazine Dm?

5

Patient Review

5/1/2021

Promethazine Dm for Cough

This treatment was very effective for my bronchitis.

5

Patient Review

4/9/2022

Promethazine Dm for Cold Symptoms

This is the only treatment that has worked for me. I was sick for three weeks with upper respiratory problems, and the last doctor I saw at MD360 recommended this. I have finally had three full nights of sleep and feeling much better!

5

Patient Review

6/29/2022

Promethazine Dm for Cough

This treatment is highly effective for treating coughs related to Covid-19.

4.7

Patient Review

10/28/2022

Promethazine Dm for Cold Symptoms

This medication was very effective at helping me fight the flu. I would wake up drenched in sweat, but it meant that the fever had broken and I could finally get some sleep. I took another dose that night and had a similar experience.

4.3

Patient Review

12/28/2021

Promethazine Dm for Cough

This treatment has helped me immensely with my cough. I was really struggling before, to the point where I didn't want to leave my house or see anyone. The promethazine-DM has made a huge difference and I'm now only coughing 10% of the time. However, I have experienced some weird dreams while taking it. Other than that, though, it's been great!

4.3

Patient Review

3/18/2020

Promethazine Dm for Cough

I didn't find this to be helpful for my cough at all. If anything, I think it made it worse.

4

Patient Review

1/14/2022

Promethazine Dm for Cough

I've been taking this for years and it's really helped me sleep. I'm a little frustrated that I wasn't prescribed the Prometh VC version, which has codeine in it, but overall this treatment has been great.

2.3

Patient Review

11/13/2019

Promethazine Dm for Cough

Unfortunately, this medicine didn't work for me at all. In fact, it made things worse as I coughed for five minutes every time I took it.

2.3

Patient Review

4/19/2019

Promethazine Dm for Cough

This medicine was prescribed to me for my cough, but it only made things worse. Not only did I not sleep at all, but my coughing fits kept me up all night.

2

Patient Review

11/10/2019

Promethazine Dm for Cough

Unfortunately, this medication made me cough more. I had to sleep upright and was still waking up coughing. The headaches from all the coughing were terrible, and I was always exhausted.

2

Patient Review

1/3/2020

Promethazine Dm for Cough

The article was great, but I'm still unclear on what an overdose looks like. It says to call 911, but what are the specific symptoms one should be looking for?

2

Patient Review

2/18/2020

Promethazine Dm for Cough

I was extremely disappointed with this product. I originally bought it to help control my cough from the flu, but it ended up keeping me awake all night long.

2

Patient Review

3/29/2019

Promethazine Dm for Cough

1.7

Patient Review

5/9/2022

Promethazine Dm for Cough

Unfortunately, this medication did not help me when I needed it most. I coughed continuously and couldn't get any rest. After a few days of usage, I decided to stop taking the medicine and thankfully started feeling better soon after.

1.7

Patient Review

10/22/2022

Promethazine Dm for Cough

NyQuil is better than this. Don't waste your time or money.

1

Patient Review

5/9/2021

Promethazine Dm for Cough

This drug has always worked wonders for me in the past, reducing cough and sinus congestion. I take two teaspoons before bed and it allows me to sleep soundly through the night.

1

Patient Review

1/7/2020

Promethazine Dm for Cough

This didn't help my cough at all. I'm going back to the doctor to ask for something else!

Patient Q&A Section about promethazine dm

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Promethazine DM?

"Promethazine DM is a combination medication that temporarily relieves symptoms related to allergies and the common cold. It is made of two ingredients, promethazine and dextromethorphan."

Answered by AI

Is promethazine a narcotic?

"Promethazine has the potential to be abused, although it is not a controlled substance. The risk of abuse is increased when it is combined with codeine, which is a combination used as a prescription medication for cough and upper respiratory symptoms accompanying allergies or a cold."

Answered by AI

Does promethazine make you sleepy?

"Promethazine is a sedating antihistamine, which means it may cause drowsiness. Non-drowsy antihistamines are less likely to have this effect."

Answered by AI

Is Promethazine DM the same as?

"Promethazine-Dm is a prescription cough syrup that helps with coughs and upper respiratory symptoms caused by colds or allergies. Promethazine is an antihistamine that eases allergy symptoms. Dextromethorphan is an opioid-like drug that stops the cough reflex in the brain's cough center."

Answered by AI

Clinical Trials for Promethazine Dm

Image of CenExel in Marlton, United States.

Epinephrine Nasal Spray for Allergy

2 - 17
All Sexes
Marlton, NJ

This Phase 2, open-label, single-arm study will evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of a single dose of epinephrine nasal spray (ENS) in children and adolescents 2 to 17 years of age with a diagnosed Type I allergy. Approximately 44 participants will be enrolled in two body-weight cohorts. * Participants weighing \>30 kg will receive a single 5.25 mg dose of ENS, and * Participants weighing ≥15 kg to ≤30 kg will receive a single 2.5 mg dose of ENS. The study will assess plasma epinephrine concentrations, changes in blood pressure and pulse rate, and safety and tolerability following administration of ENS. Participants will be monitored for 4 hours after dosing and will complete safety follow-up through approximately Day 15.

Phase 2
Waitlist Available

CenExel (+1 Sites)

Nageshwar Thudi, PhD

Hikma Pharmaceuticals USA Inc.

Image of UPMC Children's Community Pediatrics in Pittsburgh, United States.

Enhanced Telemedicine for Acute Respiratory Tract Infections

6 months - 24 months
All Sexes
Pittsburgh, PA

Young children often receive antibiotics for pediatric acute respiratory tract infections (ARTIs) - common childhood diagnoses like ear infections, strep throat, sinusitis, and colds - but many of these antibiotics are prescribed unnecessarily for viral infections, where antibiotics will not help. Helping families and pediatricians to evaluate children with ARTIs through primary care telemedicine visits using at-home tele-otoscopes vs. at-home eBooks could help reduce unnecessary antibiotic exposure in children. In this clinical trial, we will assess the impact of at-home tele-otoscope vs. eBook enabled primary care telemedicine on antibiotic use, healthcare utilization, and healthcare costs for young children.

Waitlist Available
New This Month

UPMC Children's Community Pediatrics (+1 Sites)

Kristin Ray, MD, MS

Image of Andover Eye Associates in Andover, United States.

Fel d 1 Monoclonal Antibodies for Allergic Eye

Any Age
All Sexes
Andover, MA

This study is researching two experimental medicines, freneslerbart and mevonlerbart. Freneslerbart and mevonlerbart can be given alone or together. When given together, the medicine is called "REGN-2Cat". These medicines are also known as the "study drugs". The aim of the study is to see what side effects freneslerbart, mevonlerbart, and REGN-2Cat may have and if they help reduce eye allergy symptoms caused by cat hair/dander compared with a placebo. The study is looking at several other research questions, including: * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) * How long the study drug effect lasts

Phase 3
Recruiting

Andover Eye Associates

Clinical Trial Management

Regeneron Pharmaceuticals

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Infusion Pump for Postoperative Pain

18+
All Sexes
Somerset, NJ

This study will be a pragmatic, prospective cluster randomized trial, where clusters will formed based on sequential 2 week time increments across the study recruitment period.. Patients 18 years or older undergoing ACL reconstruction, open shoulder labrum or rotator cuff surgery, arthroscopic rotator cuff repair, proximal or distal patellar realignment surgery, open knee arthrotomy cases (i.e. inside out meniscus repair, osteochondral allograft transplantation (OCA), meniscal allograft transplantation (MAT)) at University Center for Ambulatory Surgery, LLC (UOA) will be reviewed for eligibility. Once identified, potential study subjects will be asked whether they are interested in participating in the project. If the patient agrees, the subject will be given the informed consent to read and sign. Objectives: The primary objective is to compare the effectiveness of postoperative infusion pain pump versus preoperative nerve block in reducing visual analog pain scores/numerical pain rating scale (VAS/NPRS) in the postoperative period. The second objective is to evaluate the requirement of narcotic and non-narcotic analgesic medications between the two groups. Hypotheses: Use of continuous infusion pain pump or single shot peripheral block will result in similar post-operative pain control after outpatient sports medicine surgical cases.

Phase 4
Recruiting

University Center for Ambulatory Surgery

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We made a collection of clinical trials featuring Promethazine Dm, we think they might fit your search criteria.
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Image of UI Health Care Center for Advanced Reproductive Care in Iowa City, United States.

Ketorolac for Infertility Treatment

18 - 37
Female
Iowa City, IA

Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days later). The concern was that ketorolac might increase the risk of bleeding or reduce the chances of the embryo implanting in the uterus. This concern comes from how ketorolac works-it blocks certain chemicals in the body (like prostaglandins and thromboxane) that help with blood clotting and play a role in early pregnancy. However, a large review of past studies found no real evidence that ketorolac increases bleeding risk. In fact, ketorolac is now routinely used for pain relief in IVF cycles where embryos are frozen and not transferred right away. More recent studies from Boston and Chapel Hill have shown that ketorolac provides better pain control and does not appear to harm IVF outcomes, even when embryos are transferred fresh (within the same cycle). Despite these encouraging findings, many IVF clinics still avoid using ketorolac during fresh cycles because of the theoretical concerns. That's why we need stronger, higher-quality research. This study aims to fill that gap by conducting a double-blind randomized controlled trial to find out whether giving ketorolac through an IV after egg retrieval affects important IVF outcomes-especially the chance of implantation and live birth-in patients undergoing fresh embryo transfers. Patients who choose to join the study will randomly be placed into one of two groups. One group will get ketorolac (a pain medicine) after an IVF egg retrieval. The other group will not get ketorolac after egg retrieval. Everything else in their IVF care will stay the same as it normally would. Primary outcome will be implantation rate following fresh embryo transfers in patients receiving ketorolac (30mg IV) vs no ketorolac for post-retrieval analgesia. Secondary outcomes will include pain scale, narcotics required, time to discharge, need for evaluation w/in 24 hours for pain/bleeding, clinical pregnancy rates, miscarriage rates, and live birth rates following fresh embryo transfers in patients receiving ketorolac vs no ketorolac for post-retrieval analgesia.

Phase 4
Recruiting

UI Health Care Center for Advanced Reproductive Care

Image of Thomas Jefferson University in Philadelphia, United States.

Physical Therapy for Ventral Hernia

18 - 75
All Sexes
Philadelphia, PA

Ventral hernia repair is among the most common operations performed in the United States each year, yet the great majority of patients receive no structured rehabilitation for the persistent pain, weakness, and functional loss that can follow surgery. This project will establish whether a tailored, mind-and-body physical therapy program can be feasibly and equitably delivered within a novel trial design embedded in routine surgical care, generating the operational evidence needed to design a definitive efficacy trial. The results will directly inform post-operative care pathways, clinical practice guidelines, and payer coverage decisions for a surgical population exceeding 600,000 patients annually.

Waitlist Available
Has No Placebo

Thomas Jefferson University

Christopher Keating

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