36 Participants NeededMy employer runs this trial

Anti-Inflammatory Diet for Lupus

MG
Overseen ByMonica Guma, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, San Diego
Must be taking: Cellcept, Myfortic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how an anti-inflammatory diet might help people with lupus, a condition where the immune system attacks the body. Researchers aim to determine if changing eating habits can improve health and reduce symptoms. Participants must have lupus, take medication like Cellcept or Myfortic for at least three months, and frequently experience pain that disrupts daily life.

As an unphased trial, this study offers a unique opportunity to contribute to understanding how dietary changes can impact lupus symptoms.

What prior data suggests that this diet is safe for lupus patients?

Research has shown that anti-inflammatory diets are usually easy for people to follow. These diets include foods that help reduce swelling in the body, such as fruits, vegetables, and whole grains. No specific evidence indicates serious side effects from this type of diet. Many people who try it report feeling better overall. Since this study focuses on diet rather than medicine, the risk of harmful effects is low. However, consulting a doctor before making significant dietary changes is always important, especially for those with health conditions like lupus.12345

Why are researchers excited about this trial?

Unlike the standard treatments for lupus, which often include medications like corticosteroids and immunosuppressants, the anti-inflammatory diet offers a non-drug approach to managing the condition. This diet is unique because it focuses on reducing inflammation through food choices, potentially minimizing side effects associated with long-term medication use. Researchers are excited about this approach as it could empower patients to manage lupus symptoms through lifestyle changes, helping to improve their quality of life naturally.

What evidence suggests that an anti-inflammatory diet might be an effective treatment for lupus?

Studies have shown that an anti-inflammatory diet can help people with lupus by reducing symptoms and inflammation. For example, the Mediterranean diet, rich in anti-inflammatory foods, has been linked to less lupus activity. Research suggests that omega-3 fatty acids, found in fish, can lower inflammation and improve symptoms in people with lupus. Additionally, avoiding highly processed foods, which can cause inflammation, may also help those with lupus. While no cure exists for lupus, dietary changes might help manage symptoms and improve quality of life. Participants in this trial will follow an anti-inflammatory diet to evaluate its effects on lupus symptoms.678910

Who Is on the Research Team?

MG

Monica Guma, MD, PhD

Principal Investigator

UC San Diego

Are You a Good Fit for This Trial?

This trial is for people diagnosed with lupus. Specific inclusion and exclusion criteria are not listed, but generally participants should have lupus and be able to follow a special diet.

Inclusion Criteria

I have been taking Cellcept or Myfortic for at least 3 months.
Patients with a score of ≥55 on the Patient Reported Outcomes Measurement Information System (PROMIS) Pain interference scale
I have been diagnosed with lupus based on the 2019 EULAR/ACR criteria.

Exclusion Criteria

Pregnant or lactating patients
Patients with food allergy
I have taken antibiotics in the past 4 weeks.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants follow an anti-inflammatory diet for 6 weeks to study its effects on clinical and biological outcomes in lupus

6 weeks

Follow-up

Participants are monitored for safety and effectiveness after dietary intervention

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Anti-inflammatory Diet

Trial Overview

The study is testing whether following an anti-inflammatory diet can improve health outcomes in people with lupus. Participants will eat foods designed to reduce inflammation.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: anti-inflammatory dietExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, San Diego

Lead Sponsor

Trials
1,215
Recruited
1,593,000+

Citations

Should we recommend an anti-inflammatory diet for lupus?

Lupus has no known cure, but symptom management through diet and supplementation can be helpful to reduce comorbidity risk, inflammation and ...

Immunomodulatory Effects of Diet and Nutrients in ...

As a broad range of evidence has demonstrated that some diets and nutrients have antioxidant, anti-inflammatory and immunomodulatory effects on ...

Study Finds Mediterranean Diet Beneficial for People with ...

The diet includes many anti-inflammatory foods, which also reduced lupus disease activity in study participants. most closely saw lower lupus ...

An update on diet and nutritional factors in systemic lupus ...

CLA has shown beneficial effects in SLE mouse models, reducing splenomegaly, autoantibody and cytokine production, NF-κB activity (independent ...

Diet and Systemic Lupus Erythematosus (SLE)

Trials of omega-3 fatty acid supplementation presented significant reductions in ESR, CRP, disease activity, inflammatory markers, and oxidative ...

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Data.gov Home - Data.gov

Here you will find data, tools, and resources to conduct research, develop web and mobile applications, design data visualizations, and more.

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The OECD data pillar gathers all OECD data outputs from trusted statistics or indicators. It offers aggregate statistics, test the safety of chemicals for ...

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data.un.org/

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The UN System Data Commons platform integrates authoritative SDG data from across the UN System into a public repository with a user-friendly interface

Data | Open Access Journal

This Data Descriptor presents an evidence-graded database of reported tunnel failures and severe-loss events. Corpus Release 3.1 contains 78 incidents