Vagal Nerve Stimulation for Stroke

This trial tests a device that clips onto the ear to determine its effectiveness in improving sleep for people recovering from a stroke. Researchers aim to discover whether this device, which provides transauricular Vagal Nerve Stimulation, aids with insomnia and impacts stroke recovery, such as mobility or cognitive skills. Participants will use the device for 30 minutes each evening for at least 10 days. The trial seeks individuals who have experienced an ischemic stroke, are currently in a rehabilitation hospital, and have difficulty sleeping. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance stroke recovery and improve sleep.

Research has shown that vagal nerve stimulation (VNS) is generally safe and well-tolerated. Studies indicate that when used properly, complications are rare, and most side effects are mild. For example, some people might feel tingling or experience skin irritation where the device is placed. This is reassuring, especially since the device used in this trial is non-invasive and applied only to the ear.

Unlike traditional stroke rehabilitation treatments that focus on physical therapy and medications, transauricular Vagal Nerve Stimulation (taVNS) is unique because it uses a non-invasive device to stimulate the vagus nerve through the ear. This method potentially enhances cognitive function and improves sleep quality, which are critical aspects of stroke recovery. Researchers are excited about this approach as it offers a novel mechanism of action, tapping into the body's natural communication pathways to promote healing and recovery, possibly offering quicker and more integrated improvements than conventional therapies.

Research has shown that stimulating the vagus nerve through the ear (taVNS) can aid stroke recovery. In this trial, participants will receive either transauricular Vagal Nerve Stimulation (taVNS) or a Sham taVNS as part of their rehabilitation. Studies have found that combining taVNS with rehabilitation exercises leads to better recovery than rehabilitation alone. For example, some studies observed improved arm strength and movement in stroke patients using taVNS. Additionally, research on animals suggested that taVNS might reduce brain damage after a stroke. Overall, these findings indicate that taVNS could support stroke recovery, including enhancing sleep and mental function.⁶⁷⁸⁹¹⁰