Cognitive Processing Therapy for PTSD
(mCPT+CRP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if combining a brief strategy called Crisis Response Planning (CRP) with Cognitive Processing Therapy (CPT, a type of talk therapy) can reduce suicidal thoughts and behaviors in people with PTSD (posttraumatic stress disorder). The study will compare two groups: one receiving the usual safety planning treatment and the other trying the experimental CRP method. It seeks active duty service members or veterans with PTSD symptoms who have recently experienced suicidal thoughts or attempts. Participants should also regularly use a smartphone. As an unphased trial, this study offers participants the chance to contribute to innovative research that could lead to new, effective treatments for PTSD.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that these methods are safe for reducing suicidal thoughts and behaviors?
Research has shown that Cognitive Processing Therapy (CPT) is generally safe for treating post-traumatic stress disorder (PTSD). Studies have found significant improvements in PTSD symptoms, depression, and anxiety among those who received CPT. Importantly, no major safety concerns have been reported with the therapy itself.
Participants also experienced better social interactions and reduced feelings of guilt. While some may feel uncomfortable when working through difficult memories, these feelings are usually manageable. Overall, the therapy is well-tolerated, with evidence supporting its effectiveness in reducing PTSD symptoms without serious side effects.12345Why are researchers excited about this trial?
Researchers are excited about Cognitive Processing Therapy (CPT) for PTSD because it offers a structured, evidence-based approach specifically targeting the thoughts and beliefs associated with trauma. Unlike standard treatments like medication or general talk therapy, CPT focuses on helping individuals process their traumatic experiences to reduce distressing symptoms. It involves actively challenging and modifying unhelpful beliefs related to trauma, leading to long-term cognitive and emotional shifts. This approach not only addresses the symptoms but also empowers individuals by equipping them with practical tools to manage their PTSD more effectively.
What evidence suggests that this trial's treatments could be effective for PTSD?
Studies have shown that Cognitive Processing Therapy (CPT) effectively treats posttraumatic stress disorder (PTSD). Research indicates that CPT significantly improves symptoms of PTSD, depression, and anxiety. In various studies, patients experienced noticeable relief from their symptoms. Some data also show that CPT can help reduce suicidal thoughts and feelings of being a burden to others. These benefits appear both in the short term and over longer periods, suggesting lasting positive effects. Participants in this trial will receive either Safety Planning Treatment as Usual (TAU) or Crisis Response Planning (CRP) as part of the study's treatment arms.12346
Who Is on the Research Team?
Craig J Bryan
Principal Investigator
University of Vermont
Are You a Good Fit for This Trial?
This trial is for active duty service members or veterans aged 18+ who can read and speak English, have PTSD or nearly meet its criteria, have had recent suicidal thoughts or a suicide attempt in the past month, and regularly use a smartphone.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 10 daily sessions of massed Cognitive Processing Therapy (CPT) over two consecutive weeks, with either Crisis Response Planning (CRP) or usual care safety planning introduced during the intake session.
Ecological Momentary Assessment (EMA)
Participants complete EMA surveys to monitor symptoms and treatment response.
Follow-up
Participants are monitored for safety and effectiveness after treatment with follow-up assessments at 1, 3, 6, 9, and 12 months.
Optional Booster Sessions
Participants may receive optional booster sessions to reinforce treatment effects.
What Are the Treatments Tested in This Trial?
Interventions
- Cognitive Processing Therapy
Trial Overview
The study tests if adding Crisis Response Planning (CRP) to Cognitive Processing Therapy (CPT)—a talk therapy for PTSD—can better reduce suicidal thoughts and behaviors compared to CPT alone.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants assigned to this arm will receive Crisis Response Planning (CRP), a structured intervention designed to help individuals identify and manage suicidal thoughts and behaviors through a collaborative, personalized plan. CRP uses a procedural format distinct from standard safety planning.
Participants assigned to this arm will receive Safety Planning Treatment as Usual (TAU), a brief, structured intervention commonly used by mental health professionals to help individuals identify warning signs, coping strategies, and sources of support to reduce suicide risk.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor
The University of Texas Health Science Center at San Antonio
Collaborator
C.R.Darnall Army Medical Center
Collaborator
University of Vermont Medical Center
Collaborator
Citations
A meta-analytic review of cognitive processing therapy for ...
These meta-analytic findings indicate that CPT is an effective PTSD treatment with lasting benefits across a range of outcomes.
Effectiveness of Cognitive Processing Therapy for PTSD in ...
This study provides promising data on the outcomes associated with a modified CPT protocol for treating PTSD in a high need but under-treated SMI population.
Cognitive Processing Therapy for PTSD
Participants in the active treatment conditions (both CPT and PE) demonstrated significant improvement in PTSD and depression over the course of treatment as ...
Cognitive Processing Therapy for Posttraumatic Stress ...
The CPT-TAU group maintained improvements in all outcomes from 17 to 34 weeks. Sensitivity analyses controlling for the types of traumatic ...
Long-Term Outcomes of Cognitive–Behavioral Treatments for ...
CPT and PE resulted in lasting changes in PTSD and related symptoms over an extended period of time for female rape victims with extensive histories of trauma.
6.
profiles.wustl.edu
profiles.wustl.edu/en/publications/effectiveness-of-cognitive-processing-therapy-for-ptsd-in-serious/Effectiveness of Cognitive Processing Therapy for PTSD in ...
Results: The results demonstrated statistically significant changes in PTSD and depression symptoms and improvement in end-state functioning. Conclusion: ...
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