190 Participants NeededMy employer runs this trial

Cognitive Processing Therapy for PTSD

(mCPT+CRP Trial)

CR
AC
Overseen ByAnna Crouser, MSW
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Ohio State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if combining a brief strategy called Crisis Response Planning (CRP) with Cognitive Processing Therapy (CPT, a type of talk therapy) can reduce suicidal thoughts and behaviors in people with PTSD (posttraumatic stress disorder). The study will compare two groups: one receiving the usual safety planning treatment and the other trying the experimental CRP method. It seeks active duty service members or veterans with PTSD symptoms who have recently experienced suicidal thoughts or attempts. Participants should also regularly use a smartphone. As an unphased trial, this study offers participants the chance to contribute to innovative research that could lead to new, effective treatments for PTSD.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that these methods are safe for reducing suicidal thoughts and behaviors?

Research has shown that Cognitive Processing Therapy (CPT) is generally safe for treating post-traumatic stress disorder (PTSD). Studies have found significant improvements in PTSD symptoms, depression, and anxiety among those who received CPT. Importantly, no major safety concerns have been reported with the therapy itself.

Participants also experienced better social interactions and reduced feelings of guilt. While some may feel uncomfortable when working through difficult memories, these feelings are usually manageable. Overall, the therapy is well-tolerated, with evidence supporting its effectiveness in reducing PTSD symptoms without serious side effects.12345

Why are researchers excited about this trial?

Researchers are excited about Cognitive Processing Therapy (CPT) for PTSD because it offers a structured, evidence-based approach specifically targeting the thoughts and beliefs associated with trauma. Unlike standard treatments like medication or general talk therapy, CPT focuses on helping individuals process their traumatic experiences to reduce distressing symptoms. It involves actively challenging and modifying unhelpful beliefs related to trauma, leading to long-term cognitive and emotional shifts. This approach not only addresses the symptoms but also empowers individuals by equipping them with practical tools to manage their PTSD more effectively.

What evidence suggests that this trial's treatments could be effective for PTSD?

Studies have shown that Cognitive Processing Therapy (CPT) effectively treats posttraumatic stress disorder (PTSD). Research indicates that CPT significantly improves symptoms of PTSD, depression, and anxiety. In various studies, patients experienced noticeable relief from their symptoms. Some data also show that CPT can help reduce suicidal thoughts and feelings of being a burden to others. These benefits appear both in the short term and over longer periods, suggesting lasting positive effects. Participants in this trial will receive either Safety Planning Treatment as Usual (TAU) or Crisis Response Planning (CRP) as part of the study's treatment arms.12346

Who Is on the Research Team?

CJ

Craig J Bryan

Principal Investigator

University of Vermont

Are You a Good Fit for This Trial?

This trial is for active duty service members or veterans aged 18+ who can read and speak English, have PTSD or nearly meet its criteria, have had recent suicidal thoughts or a suicide attempt in the past month, and regularly use a smartphone.

Inclusion Criteria

I can read, write, and speak English.
I am a military member or veteran over 18 eligible for military medical care.
I have been diagnosed with PTSD or have symptoms of PTSD.
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive 10 daily sessions of massed Cognitive Processing Therapy (CPT) over two consecutive weeks, with either Crisis Response Planning (CRP) or usual care safety planning introduced during the intake session.

2 weeks
10 visits (in-person)

Ecological Momentary Assessment (EMA)

Participants complete EMA surveys to monitor symptoms and treatment response.

4 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment with follow-up assessments at 1, 3, 6, 9, and 12 months.

12 months
5 visits (in-person)

Optional Booster Sessions

Participants may receive optional booster sessions to reinforce treatment effects.

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive Processing Therapy

Trial Overview

The study tests if adding Crisis Response Planning (CRP) to Cognitive Processing Therapy (CPT)—a talk therapy for PTSD—can better reduce suicidal thoughts and behaviors compared to CPT alone.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Crisis Response Plan (CRP)Experimental Treatment1 Intervention
Group II: Safety Plan (TAU)Active Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Ohio State University

Lead Sponsor

Trials
891
Recruited
2,659,000+

The University of Texas Health Science Center at San Antonio

Collaborator

Trials
486
Recruited
92,500+

C.R.Darnall Army Medical Center

Collaborator

Trials
17
Recruited
5,800+

University of Vermont Medical Center

Collaborator

Trials
46
Recruited
25,900+

Citations

1.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/30332919/

A meta-analytic review of cognitive processing therapy for ...

These meta-analytic findings indicate that CPT is an effective PTSD treatment with lasting benefits across a range of outcomes.

Effectiveness of Cognitive Processing Therapy for PTSD in ...

This study provides promising data on the outcomes associated with a modified CPT protocol for treating PTSD in a high need but under-treated SMI population.

Cognitive Processing Therapy for PTSD

Participants in the active treatment conditions (both CPT and PE) demonstrated significant improvement in PTSD and depression over the course of treatment as ...

Cognitive Processing Therapy for Posttraumatic Stress ...

The CPT-TAU group maintained improvements in all outcomes from 17 to 34 weeks. Sensitivity analyses controlling for the types of traumatic ...

Long-Term Outcomes of Cognitive–Behavioral Treatments for ...

CPT and PE resulted in lasting changes in PTSD and related symptoms over an extended period of time for female rape victims with extensive histories of trauma.

Effectiveness of Cognitive Processing Therapy for PTSD in ...

Results: The results demonstrated statistically significant changes in PTSD and depression symptoms and improvement in end-state functioning. Conclusion: ...