ENDS Flavors for Smoking
What You Need to Know Before You Apply
What is the purpose of this trial?
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine delivery system (ENDS) power unit (2) and varying levels of access to tobacco-flavored, menthol-flavored, mint, or non-tobacco/non-menthol/non-mint-flavored cartridge-based e-liquids (collectively referred to as the investigational product) within their assigned study arm over a three-month (ninety-day) period.
Who Is on the Research Team?
Melissa Tapia, Ph.D.
Principal Investigator
RAIS Company
Are You a Good Fit for This Trial?
This trial is for adults aged 21-65 who are generally healthy, currently smoke at least 5 cigarettes on most days, have smoked at least 100 cigarettes in their life, are willing to try e-cigarettes (ENDS), and can use a smartphone. Pregnant individuals or those planning pregnancy cannot join.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Trial Period
Participants sample available flavors within their Study Arm for one week
Treatment
Participants use ENDS and complete surveys; flavor changes allowed at specified visits
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Trial Overview
The study tests if giving smokers different flavors of e-cigarette cartridges (tobacco, menthol, mint, or other) affects whether they quit regular cigarette smoking over three months. Participants are randomly assigned to groups with varying flavor access.
How Is the Trial Designed?
3
Treatment groups
Active Control
Participants can choose between tobacco and two non-tobacco/non-menthol/mint flavor variants at one nicotine level (5%).
Participants can choose between tobacco, mint, and menthol flavor variants at one nicotine level (5%).
Participants can use a tobacco flavor variant at one nicotine level (5%).
Find a Clinic Near You
Who Is Running the Clinical Trial?
RAI Services Company
Lead Sponsor
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