PrEP Decisional Aid for HIV Prevention

(DASH Trial)

Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Michigan
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new app designed to help individuals using HIV self-test kits learn about PrEP, a medication that prevents HIV, and decide if it suits them. By integrating this tool with self-testing, the trial aims to simplify understanding of options and access to PrEP if needed. Participants will be divided into two groups: one using the app and one not, to evaluate the app's effectiveness. This trial may suit those comfortable with English, with internet access, who are HIV negative, and have never used PrEP. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could simplify access to HIV prevention methods.

Do I have to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It focuses on people who have never used PrEP before.

What prior data suggests that the PrEP Decisional Aid is safe for users?

Research has shown that the PrEP Decisional Aid (DASH app) helps people make informed decisions about using PrEP, a proven method to prevent HIV. Studies have demonstrated that PrEP is safe and effective, reducing the risk of contracting HIV by up to 99% when taken as directed. This makes it a well-accepted option for those at risk of HIV.

Regarding the DASH app, no safety concerns exist because it is a digital tool that provides information and aids decision-making. It is not a medicine or treatment; instead, it helps users understand and access PrEP. Since the app assists with decisions rather than directly impacting health, it is considered safe to use.12345

Why are researchers excited about this trial?

Researchers are excited about the PrEP Decisional Aid for dissemination with Self-administered HIV test kits (DASH) because it offers a novel approach to HIV prevention. Unlike traditional methods that rely on in-person consultations and guidance, DASH provides a digital tool that can be easily accessed through an app. This approach empowers individuals by offering them information and reminders in a user-friendly way, potentially increasing adherence to PrEP usage. The convenience and accessibility of this method could significantly enhance the reach and effectiveness of HIV prevention strategies, especially among populations that face barriers to accessing healthcare services.

What evidence suggests that the DASH app is effective for increasing PrEP uptake among HIV self-test users?

Research shows that PrEP (pre-exposure prophylaxis) effectively prevents HIV when taken correctly. Studies indicate that daily PrEP use can reduce the risk of contracting HIV from sex by 99% and from injecting drugs by at least 74%. In this trial, participants in the DASH Intervention Arm will access the DASH app, which helps individuals decide if PrEP suits them by guiding them through the process and considering their personal needs and values. Previous research has shown that tools like this can increase PrEP use by identifying those at risk and encouraging them to start treatment. This method empowers users to take charge of their health and lower their risk of HIV infection.23678

Who Is on the Research Team?

KR

K Rivet Amico, PhD

Principal Investigator

University of Michigan

Are You a Good Fit for This Trial?

This trial is for people who are using at-home HIV self-test kits through the CDC's Together TakeMeHome program. Participants should be interested in learning more about HIV prevention and considering PrEP as an option.

Inclusion Criteria

Comfort with English material and communication (oral and written)
Access to internet
HIV negative (self-report)
See 2 more

Exclusion Criteria

I have used PrEP before.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pilot Study

Participants are recruited and randomly assigned to either the DASH intervention arm or the comparison condition. They complete online surveys assessing PrEP awareness, knowledge, intentions, and use.

3 months
Online surveys at baseline, 1 month, and 3 months

Follow-up

Participants are monitored for changes in PrEP uptake, knowledge, and other related factors. Additional qualitative interviews are conducted with a subset of participants.

3 months
Online surveys and virtual interviews

What Are the Treatments Tested in This Trial?

Interventions

  • PrEP Decisional Aid for dissemination with Self-administered HIV test kits (DASH)

Trial Overview

The study is testing a new, interactive website (DASH app) designed to help users of HIV self-test kits learn about PrEP, decide if it's right for them, and connect with local or online resources. Participants will be randomly assigned to use this tool or not.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: DASH Intervention ArmExperimental Treatment1 Intervention
Group II: Comparison conditionActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Michigan

Lead Sponsor

Trials
1,891
Recruited
6,458,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Citations

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