Resistance Training for Muscle Weakness

(MiND Trial)

This trial aims to understand how muscle weakness develops when an arm is immobilized and whether exercising the opposite arm can help maintain strength. Researchers will study women who wear a wrist cast on one arm for a week, comparing those who perform resistance training (a type of strength exercise) with the opposite arm to those who do not. The trial targets right-handed women aged 40-65 with a grip strength over 20 kg and no recent upper-body injuries or surgeries. Participants will undergo non-invasive tests to assess how their muscles and nerves respond. As an unphased trial, this study allows participants to contribute to the scientific understanding of muscle maintenance strategies.

The trial requires that you do not use certain medications, like anticoagulants, muscle relaxants, benzodiazepines, or body composition-altering drugs. If you are taking any of these, you would need to stop before participating.

Research has shown that resistance training is generally safe for most people. It can enhance muscle strength and function in various groups, including older adults and young athletes. A review of studies found that traditional strength training is among the safest types, with a low risk of injury. Therefore, the exercises in the trial should be manageable. However, following the study's guidelines and instructions is crucial to minimize any potential risks.¹²³⁴⁵

Researchers are excited about resistance training for muscle weakness because it takes a physical, non-pharmaceutical approach to building strength. Unlike medications that target muscle weakness by addressing symptoms or underlying causes through chemical means, resistance training directly engages muscles, promoting growth and increased strength through physical activity. This method can be particularly appealing for individuals seeking natural and holistic approaches to improving muscle health, offering a direct and empowering way to combat weakness without relying on drugs.

Research has shown that strength training can combat muscle weakness and wasting due to inactivity. In this trial, participants in the Intervention Group (TRAIN) will receive resistance training as the experimental intervention. Studies have found that strength exercises can prevent muscles from weakening during periods of disuse, such as when an arm or leg is in a cast. Evidence also suggests that exercising one arm can help maintain the strength of the other, unused arm. This concept, known as cross-education, indicates that exercising the active arm might preserve the strength and function of the immobilized arm. Overall, strength training is a proven method to maintain muscle health and prevent weakness.⁶⁷⁸⁹¹⁰