Digital Weight Loss Intervention for Obesity and Type 2 Diabetes Risk

(mLIFE Trial)

This trial tests whether a digital app can aid in weight loss and reduce the risk of type 2 diabetes. The app, called mLIFE, uses engaging, game-like features to promote healthy habits, such as tracking food intake and obtaining social support. Researchers aim to determine if the gaming version of the app results in greater weight loss and improved social support compared to the non-gaming version. The trial seeks adults who are overweight, own a smartphone, and have three or more risk factors for type 2 diabetes. As an unphased trial, it offers participants the chance to contribute to innovative research that could lead to new, engaging methods for managing weight and preventing diabetes.

The trial requires that you do not use medications that may impact blood glucose. If you are taking such medications, you may need to stop them to participate.

Research has shown that the mLIFE app, tested for weight loss, may help people manage their weight and lower the risk of type 2 diabetes. The app allows users to track habits and receive support from others. Studies have found that mobile apps like mLIFE can improve self-care and diabetes control, suggesting they are generally safe.

The mLIFE app also uses social gaming to encourage weight loss by awarding points for social support. Previous research found this game-like approach effectively increases engagement without major safety concerns. Overall, these features are well-tolerated, with no significant reports of negative effects from using the app.

Researchers are excited about the mLIFE app treatments for obesity and Type 2 diabetes risk because they offer a unique approach by integrating digital tools for self-regulation and social support. Unlike traditional methods like diet plans and medications, the mLIFE app introduces a gamified experience, fostering healthy competition among users to encourage sustained engagement and motivation. This social gaming element aims to make weight loss efforts more interactive and enjoyable, potentially leading to better adherence and outcomes. Moreover, the app's self-regulation features empower users to track their progress and make informed decisions, distinguishing it from more passive treatment options.

Research has shown that the mLIFE app, which aids in self-control and support from others, can effectively assist with weight loss. In this trial, participants will be assigned to different groups using the mLIFE app. One group will use a gamified version of the app, which includes points to encourage support from friends, resulting in more weight loss than similar programs without this feature. This version allows users to send encouraging messages and "likes" to each other upon reaching goals, fostering a supportive community. Early results suggest that adding game-like features enhances effectiveness, leading to greater weight loss. Evidence indicates that these social features can help individuals with obesity or at risk for Type 2 diabetes lose weight over 12 months.³⁶⁷⁸⁹