Cognitive Training for Multiple Myeloma

This trial examines whether an online program can improve thinking and memory in people with specific types of cancer. It targets individuals with multiple myeloma or B-cell non-Hodgkin lymphoma that have recurred or are unresponsive to treatment. The program, called I-CAN (Intervention to enhance Cognitive Augmentation and Neuroplasticity), serves as a brain exercise to help patients manage the mental side effects of their cancer treatment. Participants should be comfortable reading English and plan to receive CAR-T therapy. As an unphased trial, this study provides patients the chance to contribute to innovative research that could enhance cognitive health during cancer treatment.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that cognitive training programs like I-CAN are generally safe. Studies have found that these programs can enhance brain function without harmful side effects. They help the brain form new connections, boosting memory, attention, and other mental skills.

While specific safety details about I-CAN are not provided, similar programs have been well-received by participants, with few, if any, negative effects reported. Participants in these programs usually experience improvements in thinking skills with minimal risk.

Unlike the standard treatments for multiple myeloma, which typically involve chemotherapy, stem cell transplants, or CAR-T therapy, I-CAN focuses on enhancing cognitive function through neuroplasticity. This approach is unique because it utilizes online cognitive training sessions to support brain health, potentially improving patients' mental sharpness before and after CAR-T therapy. Researchers are excited about I-CAN because it offers a non-invasive way to address cognitive challenges associated with multiple myeloma, providing a holistic boost to patients' overall treatment experience.

Research has shown that programs like I-CAN can improve brain function, particularly in attention and memory. In this trial, participants will engage in the I-CAN program, which aims to strengthen brain connections and enhance thinking skills by focusing on processing speed and accuracy. Studies indicate that such programs can significantly boost cognitive abilities and slow mental decline. Specifically, the I-CAN program has noticeably improved attention and slowed cognitive decline, as measured by tests like the Montreal Cognitive Assessment. Overall, this type of cognitive training appears promising in helping patients manage mental side effects from treatments like CAR-T therapy.¹⁶⁷⁸⁹