Supportive Care Delivery for Acute Myeloid Leukemia

(ACTIVE DEFAULT Trial)

The goal of this clinical trial is to test a way of delivering supportive care to adults 60 years and older who are starting venetoclax-based treatment for newly diagnosed acute myeloid leukemia (AML). Older adults with AML often have aging-related needs, such as problems with mobility, nutrition, mood, memory, or medications, that are not always addressed in a consistent way. In this study, a health questionnaire and short in-person checks (a geriatric assessment) are used to find these needs early, and matching supportive care orders are prepared in the electronic health record and sent to the treating doctor, who decides whether to place each one. This approach is called Active Default. The main questions the study aims to answer are:

* How often are the prepared supportive care orders signed by treating doctors (implementation fidelity)?

* Can each step of the process, from completing the assessment to receiving supportive care services, be carried out as planned?

Participants will:

* Complete questionnaires and short in-person checks of walking, balance, strength, memory, mood, and medications at the start of treatment

* Receive supportive care services (for example physical therapy, nutrition, or social work) if their doctor approves the prepared orders

* Answer phone check-ins over 90 days and repeat two short checks at about two months

* Be invited to one optional interview about their experience

Healthcare providers involved in participants' care will be invited to complete a one-time survey and an optional interview about the approach.