10 Participants NeededMy employer runs this trial

Cough Skill Training for Head and Neck Cancer

JB
Overseen ByJames Borders, PhD CCC-SLP
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Boston University Charles River Campus
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new method to help individuals with head and neck cancer improve their cough. The goal is to determine if practicing cough skills can make coughing stronger and more effective, particularly when food or drink is aspirated. Participants will use a special device to practice coughing over five sessions. Suitable candidates have had head and neck cancer, completed their cancer treatments, and can cough on command. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance the quality of life for future patients.

What prior data suggests that this cough skill training is safe for head and neck cancer patients?

In a previous study, all participants attended a cough skill training session without experiencing negative side effects. The training improved their cough strength, as evidenced by a 0.77-liter-per-second increase in peak expiratory flow rate (PEFR). Another study found that participants generally liked the treatment, giving it a usability score of 70 out of 100, indicating ease of use and satisfaction.

These findings suggest that cough skill training is well-tolerated and may be safe for people with head and neck cancer. Related studies have reported no major safety issues, supporting its safety.12345

Why are researchers excited about this trial?

Researchers are excited about the Cough Skill Training for head and neck cancer patients because it offers a non-invasive approach to improving cough reflex. Unlike standard treatments that may involve medications or surgeries to manage cough issues, this method uses a handheld device to help patients practice voluntary coughing. This technique could empower patients to manage their symptoms more effectively and potentially improve their quality of life without the need for additional medical interventions.

What evidence suggests that cough skill training is effective for head and neck cancer?

Research has shown that practicing cough skills can help people with head and neck cancer improve their coughing ability. One study found that participants increased their air expulsion speed by 0.77 liters per second. All participants completed the training without issues, indicating it is safe and feasible. In this trial, participants will engage in cough skill training using a handheld cough device during five one-hour treatment sessions. These findings suggest that practicing cough skills can help manage swallowing issues and prevent food or liquid from entering the airway.678910

Who Is on the Research Team?

JB

James Borders, PhD CCC-SLP

Principal Investigator

Boston University Charles River Campus

Are You a Good Fit for This Trial?

This trial is for adults who had head and neck cancer, finished their treatment at least 6 months ago, are medically stable, can understand instructions in English, and can cough on command. People with recent smoking history, certain lung or heart conditions, neurological diseases, or trouble following instructions cannot join.

Inclusion Criteria

I have finished all treatments for head and neck cancer.
I am medically stable and able to follow instructions and cough on command.
English speaking
See 1 more

Exclusion Criteria

Unable to follow study instructions
Smoking within the past five years
I have asthma or bronchitis.
See 9 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Evaluation

Participants complete an initial in-person baseline evaluation of voluntary cough function

1 day
1 visit (in-person)

Treatment

Participants undergo five weekly telehealth treatment sessions for cough skill training with home practice

5 weeks
5 visits (virtual)

Post-treatment Evaluation

Participants complete a post-treatment in-person evaluation

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Cough Skill Training

Trial Overview

The study tests if using a handheld device to practice coughing helps people with past head and neck cancer improve their ability to cough when needed. The main focus is whether this training approach is practical and shows immediate benefits.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Cough skill trainingExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Boston University Charles River Campus

Lead Sponsor

Trials
125
Recruited
14,100+

Citations

Efficacy of a novel swallowing exercise program for chronic ...

Results: Feasibility in terms of the program completion rate was 88%. Compliance with the exercises was 97%. After the training period, chin ...

Single-Session Feasibility of Cough Skill Training in ...

All participants completed every trial of CST in less than one hour without any adverse events. PEFR improved by 0.77 L/s (95% CI: 0.37, 1.09) on single and ...

Exercise and Nutrition Interventions in Patients with Head ...

The aim of this meta-analysis was to examine the effects of nutritional and physical exercise interventions and interventions combining these interventions ...

Award NIHR303061

It seems to work well and improves swallowing for people with head and neck cancer. However, this training programme requires expensive equipment and a lot of. ...

Feasibility of Cough Skill Training in Individuals With Head ...

The investigators hypothesize that the treatment will be feasible and will result in improvements to voluntary cough peak expiratory flow rate.

Treatment Acceptability and Satisfaction With Cough Skill ...

Results: While treatment demonstrated adequate acceptability with a System Usability Scale median score of 70/100 (scores ≥ 70 indicate acceptability), ...

This study by Manduchi et al. (2026) demonstrated ...

After an 8-week training protocol, expiratory muscle strength improved significantly, and swallowing function improved in a meaningful subset ...

Assessment of cough in head and neck cancer patients at ...

This article surveys the literature regarding the established cough assessment and stresses the need to implement innovative methods for ...

Swallowing Exercise During Head and Neck Cancer ...

The trial found no effect on swallowing safety in HNC undergoing radiotherapy, but several positive effects were found on secondary outcomes