Tear Fluid for Glioblastoma Detection
What You Need to Know Before You Apply
What is the purpose of this trial?
This clinical trial tests the impact of tear fluid in detecting tumor-associated extracellular vesicles (TEVs) in patients with glioblastoma. Brain tumors release small particles, called TEVs, that may provide information about the tumor, including how it responds to treatment. These particles can be found in cerebrospinal fluid (CSF), which is the fluid that surrounds the brain and spinal cord. Collecting CSF can be difficult and expensive, especially if samples are needed frequently to track these particles over time. Tear fluid is easier to collect than spinal fluid. If tears are found to contain similar tumor-related particles, changes in the tumor may be tracked by studying the particles found in tear fluid.
Who Is on the Research Team?
Lisa A Feldman
Principal Investigator
City of Hope Medical Center
Are You a Good Fit for This Trial?
This trial is for people diagnosed with glioblastoma, a type of brain tumor. There are no detailed inclusion or exclusion criteria listed, but participants must have this diagnosis.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Phase 1
Patients and healthy controls undergo collection of tears on study
Phase 2
Patients and healthy controls undergo collection of tears and blood samples, and patients undergo collection of standard of care CSF samples throughout the study
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Trial Overview
Researchers are studying whether tear fluid can be used to detect tumor-related particles in glioblastoma patients. The study involves collecting tears and reviewing health records and questionnaires—no new drugs or treatments are given.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Patients and healthy controls undergo collection of tears and blood samples and patients undergo collection of standard of care CSF samples throughout the study.
Patients and healthy controls undergo collection of tears on study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
City of Hope Medical Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
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