Exploration for Epilepsy
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand the relationship between certain brain activities and visual and physical exploration in people with epilepsy. Participants will either explore virtual environments using VR glasses or walk between rooms while researchers monitor brain signals. Suitable candidates include individuals with epilepsy who have specific brain implants and experience fewer than one debilitating seizure per week, as well as healthy individuals who can walk and wear research equipment without assistance. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research in understanding epilepsy and brain function.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that the treatments under study in this trial, Ambulatory Exploration and Visual Exploration, are generally safe.
For Ambulatory Exploration, studies have found that using devices to monitor seizures is usually well-tolerated. One long-term study lasting nine years showed that these brain devices reduced seizures by an average of 75%, with no major safety issues reported.
Regarding Visual Exploration, safety appears promising as well. Past research on visually sensitive seizures found that treatments involving visual tasks are safe for patients. Studies on pattern-sensitive epilepsy, a type of epilepsy triggered by visual patterns, have shown that patients handle these visual treatments well over long periods.
Overall, both treatments have been studied extensively, and the results suggest they are safe for people with epilepsy. This should provide some reassurance for those considering joining a trial testing these methods.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores innovative techniques to understand and potentially improve epilepsy management. Unlike traditional epilepsy treatments, which often rely on medications or surgeries to control seizures, this trial uses immersive virtual reality environments to study eye movements and brain activity. By analyzing how patients interact with different visual and physical spaces, the trial aims to uncover new insights into brain function and how it relates to epilepsy. These findings could open the door to more personalized and effective strategies for managing the condition.
What evidence suggests that this trial's treatments could be effective for epilepsy?
In this trial, participants will engage in various exploration tasks to manage epilepsy. Research has shown that walking around and monitoring for seizures can aid in epilepsy management. Studies have found that a portable brain wave test, known as ambulatory EEG, detects seizures 72% of the time, outperforming older methods. This improved detection helps doctors better understand and treat epilepsy.
Research has also explored the relationship between visual experiences and epilepsy. Some studies suggest that specific visual tasks can help predict seizures. These studies use advanced methods like machine learning to analyze brain activity patterns and foresee possible seizures, providing a valuable tool for managing epilepsy. Participants in this trial will engage in either ambulatory exploration or visual exploration tasks to further investigate these findings.14678Who Is on the Research Team?
Anli Liu, MD, MA
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
This trial is for individuals with epilepsy who are undergoing surgical treatment or have been implanted with RNS devices. It aims to understand the brain's activity during visual and physical exploration tasks.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Visual Exploration in Surgical Patients
Participants will view between 10-15 panoramic environments using Meta Quest AR/VR glasses while their eye movements and head turns are tracked.
Ambulatory Exploration in RNS Patients and Healthy Controls
Participants will walk through and explore visually distinct rooms while wearing synchronized high-density EEG (hdEEG), eye-tracking glasses, and body position sensors.
Follow-up
Participants are monitored for safety and effectiveness after exploration activities
What Are the Treatments Tested in This Trial?
Interventions
- Ambulatory Exploration
- Visual Exploration
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator