Intraoperative Oxygenation for Surgery

(IntraOp Ox Trial)

This trial explores how varying oxygen levels during surgery affect recovery and the risk of organ injury post-operation. It tests three oxygen strategies: lower, intermediate, and higher levels administered to patients under anesthesia. The goal is to determine which level aids recovery most effectively. It suits adults undergoing surgery that requires a breathing tube. As an unphased trial, this study provides a unique opportunity to contribute to important research that could enhance surgical outcomes for future patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that the amount of oxygen given during surgery can affect patient recovery. Lower oxygen levels (FiO2 0.21-0.40) might help prevent lung collapse but could increase other risks. Studies have found that higher oxygen levels (FiO2 0.80-1.00) might cause lung issues post-surgery, although some research suggests no significant harm from using more oxygen. Intermediate oxygen levels (FiO2 0.40-0.80) appear safe, without leading to serious problems like ICU admissions or deaths.

Researchers are excited about this trial because it explores different oxygenation practices during surgery, which could significantly impact patient outcomes. Unlike traditional methods that often use a standardized oxygen level, this trial investigates varying oxygen concentrations, specifically lower, intermediate, and higher fractions of inspired oxygen (FiO2). By understanding how different oxygen levels affect surgical patients, this research could pave the way for more personalized and potentially safer anesthesia protocols. This approach might reduce complications related to excessive or insufficient oxygenation, optimizing recovery and improving overall surgical success.

This trial will compare different intraoperative oxygenation practices—specifically lower, intermediate, and higher FiO2 levels—to determine their effects on health outcomes after surgery. Research has shown that the amount of oxygen given during surgery can affect health outcomes afterward. Studies have found that higher oxygen levels can reduce the risk of infections at the surgery site but might cause lung problems. Conversely, lower oxygen levels can decrease the chance of lung issues but might increase the risk of infection. Moderate oxygen levels fall between these two and may help balance the benefits and risks. The optimal oxygen level might depend on the type of surgery and the patient's health.¹³⁴⁶⁷