Magnesium Supplementation for Sleep
(Mg-Form Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized, double-blind, placebo-controlled trial will compare magnesium glycinate, magnesium L-threonate, and placebo in UCLA varsity athletes. Participants will complete a baseline monitoring period followed by 4 weeks of blinded nightly supplementation. WHOOP 4.0 data will be used to evaluate sleep efficiency, total sleep time, sleep consistency, heart rate variability, resting heart rate, and recovery metrics. Baseline and final testing will assess selected reaction and physical performance outcomes. The primary outcome is change in WHOOP-derived sleep efficiency from baseline week to final treatment week.
Who Is on the Research Team?
Jeremy Swisher, MD
Principal Investigator
University of California, Los Angeles
Joshua Goldman, MD
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for UCLA varsity athletes who want to improve their sleep, recovery, and athletic performance. Participants should be healthy enough to take part in a supplement study and able to wear a fitness tracker at night.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Monitoring
Participants undergo baseline assessments and wearable monitoring
Treatment
Participants receive blinded nightly supplementation with magnesium glycinate, magnesium L-threonate, or placebo
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Magnesium glycinate
- Magnesium L-threonate
Trial Overview
The study compares two types of magnesium supplements (magnesium glycinate and magnesium L-threonate) with a placebo. Athletes are randomly assigned to one group, taking the supplement nightly for 4 weeks while their sleep and performance are monitored.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Placebo Group
Participants randomized to this arm will take exactly two blinded capsules containing 1 g Magtein (magnesium L-threonate) each nightly for 4 weeks (28 days), for 2 g Magtein nightly. This corresponds to 156 mg elemental magnesium nightly based on the linked raw-ingredient certificate of analysis reporting 7.8% magnesium. The capsules are clear/natural size 00-EL HPMC capsules containing white powder. Take the two capsules approximately 1 hour before intended bedtime, with food, while upright, and with at least 8 oz water. There is no study product during the 1-week baseline period.
Participants randomized to this arm will take exactly two blinded magnesium glycinate capsules nightly for 4 weeks (28 days). Each capsule is labeled to provide 120 mg elemental magnesium, for 240 mg by label claim nightly; the lot-specific assay reports 144 mg per capsule, for 288 mg by assay nightly. The capsules are clear/natural size 00-EL HPMC capsules containing white powder. Take the two capsules approximately 1 hour before intended bedtime, with food, while upright, and with at least 8 oz water. There is no study product during the 1-week baseline period.
Participants randomized to this arm will take exactly two matched placebo capsules nightly for 4 weeks (28 days). Each capsule contains calcium laurate 300 mg plus silicified microcrystalline cellulose 440 mg and no active magnesium. The capsules are clear/natural size 00-EL HPMC capsules containing white powder. Take the two capsules approximately 1 hour before intended bedtime, with food, while upright, and with at least 8 oz water. There is no study product during the 1-week baseline period. The study uses one matched-placebo regimen and no double-dummy design.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor
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