Ferumoxytol for Heart Failure
What You Need to Know Before You Apply
What is the purpose of this trial?
Subjects undergo a gadolinium-based CMR followed by an iron infusion and then a repeat CMR in 72 hours
Who Is on the Research Team?
Ellen C Keeley, MD, MS
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
This trial is for people diagnosed with heart failure where the heart still pumps normally (preserved ejection fraction). Specific inclusion and exclusion criteria are not listed, but participants must be able to safely undergo MRI scans and iron infusions.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline CMR and Iron Infusion
Participants undergo a gadolinium-based cardiac MRI and receive an iron infusion on the same day
Follow-up CMR
Participants return for a follow-up cardiac MRI 72 hours after the iron infusion
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ferumoxytol infusion
Trial Overview
The study tests whether an iron infusion called ferumoxytol affects inflammation in the hearts of people with this type of heart failure. Participants get a special MRI scan before and after receiving the iron infusion.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Subjects with HFpEF undergo a baseline gadolinium based cardiac MRI and the same day they undergo an iron infusion. Three days later they return for a follow-up cardiac MRI and the iron that has been administered 72 hours ago serves as the contrast media
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
American Heart Association
Collaborator
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