Oral Minoxidil for Chemotherapy-Induced Alopecia

This trial aims to explore whether low-dose oral minoxidil can treat permanent hair loss caused by chemotherapy. The study will evaluate the treatment's effectiveness for individuals who completed chemotherapy at least six months ago. It seeks participants diagnosed with permanent chemotherapy-induced hair loss. Those who have experienced this type of hair loss and finished chemotherapy more than six months ago may find this trial suitable. As an Early Phase 1 trial, this research focuses on understanding how the treatment works in people, offering participants a chance to contribute to groundbreaking research.

The trial does not specify if you must stop all current medications, but you cannot participate if you are taking certain drugs that affect blood pressure or are on guanethidine without a 1-week break. If you're on any listed medications, further evaluation is needed to determine eligibility.

Previous studies have found low-dose oral minoxidil to be generally safe for treating hair loss. Research shows that side effects are rare, with only about 1.7% of patients discontinuing use due to them. This indicates that most people tolerate it well. However, while it is considered safe for hair loss, its safety during chemotherapy remains uncertain. Consulting a healthcare provider is important to understand the potential risks and benefits for each specific situation.¹²³⁴⁵

Oral minoxidil is unique because it offers a new approach to treating chemotherapy-induced alopecia by using an oral delivery method rather than topical applications. While most current treatments involve topical solutions or wigs to manage hair loss, oral minoxidil targets the problem systemically, potentially promoting hair growth from the inside out. Researchers are excited because this could mean more consistent and effective results for patients, offering a simpler and potentially more reliable solution to hair loss during chemotherapy.

Research has shown that oral minoxidil may help with hair loss caused by chemotherapy. Some patients have experienced positive results with hair regrowth. In this trial, participants will receive a low dose of oral minoxidil. Studies indicate that this can either promote hair regrowth or prevent further hair loss in individuals with this condition. Early reports suggest this treatment might be effective for both the front and back of the head. Although more research is needed, these initial findings offer promise for those experiencing hair loss from chemotherapy.¹²³⁶⁷