Dynacin

Rocky Mountain Spotted Fever, Relapsing Fever, Trachoma + 22 more

Treatment

7 Active Studies for Dynacin

What is Dynacin

Minocycline

The Generic name of this drug

Treatment Summary

Minocycline is an antibiotic used to treat bacterial infections. It was discovered in 1966 and approved by the FDA in 1971. Minocycline belongs to a group of drugs called tetracyclines and has been modified to make it more effective than other tetracyclines. It works against both gram-positive and gram-negative bacteria.

Minocin

is the brand name

image of different drug pills on a surface

Dynacin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Minocin

Minocycline

1990

305

Effectiveness

How Dynacin Affects Patients

Minocycline is an antibiotic used to treat bacterial infections. It is typically taken 2-4 times per day. Taking more than 400mg in a day can lead to serious side effects, so patients should be warned of the risks associated with minocycline use, such as tooth and bone development issues, colitis, side effects on the nervous system, and pseudotumor cerebri.

How Dynacin works in the body

Tetracyclines enter bacteria and stop protein synthesis by blocking the ribosomes. They do this by diffusing into the bacterial cytoplasm and attaching to cations like magnesium. This allows them to move into the periplasm and stop the binding of aminoacyl-tRNA to the ribosome. This prevents the bacteria from creating proteins, which is essential for survival.

When to interrupt dosage

The quantity of Dynacin is contingent upon the determined disorder, including Periodontitis, Rickettsialpox and Lymphogranuloma Venereum. The amount of dosage can be found in the table below, based on the technique of delivery (e.g. Capsule, extended release or Tablet, film coated, extended release).

Condition

Dosage

Administration

Gum Disease

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Psittacosis

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Campylobacter fetus

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Brucellosis

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Lymphogranuloma Venereum

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Granuloma Inguinale

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Respiratory Tract Infections

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Inflammation

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Urethritis

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Typhus, Endemic Flea-Borne

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Rickettsia Infections

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Cat-Scratch Disease

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Dental Root Planing

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Plague

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Acne Vulgaris

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Rickettsialpox

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Disease

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Rocky Mountain Spotted Fever

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Relapsing Fever

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Trachoma

, 75.0 mg, 45.0 mg, 90.0 mg, 135.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 1.0 mg, 65.0 mg, 115.0 mg, 55.0 mg, 105.0 mg, 67.5 mg, 112.5 mg, 0.04 mg/mg, 0.015 mg/mg, 1.0 mg/mg

, Oral, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Kit, Tablet - Oral, Tablet, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intravenous, Injection, Injection - Intravenous, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Powder, Topical, Aerosol, foam - Topical, Aerosol, foam

Warnings

Dynacin has two contraindications. It should not be utilized if you are encountering any of the conditions specified in the following table.

Dynacin Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Minocycline may interact with Pulse Frequency

There are 20 known major drug interactions with Dynacin.

Common Dynacin Drug Interactions

Drug Name

Risk Level

Description

Amdinocillin

Major

The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Minocycline.

Amoxicillin

Major

The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Minocycline.

Ampicillin

Major

The therapeutic efficacy of Ampicillin can be decreased when used in combination with Minocycline.

Aspoxicillin

Major

The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Minocycline.

Azidocillin

Major

The therapeutic efficacy of Azidocillin can be decreased when used in combination with Minocycline.

Dynacin Toxicity & Overdose Risk

The lowest toxic dose of minocycline in rats is 2380mg/kg and in mice is 3600mg/kg. The lowest toxic dose in rats when given by injection is 331mg/kg, and in mice is 299mg/kg. When given under the skin, the lowest toxic dose in rats is 1700mg/kg and in mice is 2290mg/kg.Those who overdose on minocycline may experience dizziness, nausea, and vomiting. If this occurs, it is important to stop taking minocycline and seek medical support.

image of a doctor in a lab doing drug, clinical research

Dynacin Novel Uses: Which Conditions Have a Clinical Trial Featuring Dynacin?

Ten ongoing investigations are examining the potential of Dynacin for the alleviation of Psittacosis, Tularemia and other Diseases.

Condition

Clinical Trials

Trial Phases

Gum Disease

4 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Trachoma

2 Actively Recruiting

Phase 4, Not Applicable

Lymphogranuloma Venereum

0 Actively Recruiting

Disease

0 Actively Recruiting

Psittacosis

0 Actively Recruiting

Respiratory Tract Infections

2 Actively Recruiting

Phase 3, Not Applicable

Dental Scaling

0 Actively Recruiting

Typhus, Endemic Flea-Borne

0 Actively Recruiting

Acne Vulgaris

0 Actively Recruiting

Relapsing Fever

0 Actively Recruiting

Plague

0 Actively Recruiting

Cat-Scratch Disease

0 Actively Recruiting

Rocky Mountain Spotted Fever

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Brucellosis

0 Actively Recruiting

Rickettsia Infections

0 Actively Recruiting

Chancroid

0 Actively Recruiting

Q Fever

0 Actively Recruiting

Conjunctivitis, Inclusion

0 Actively Recruiting

Rickettsialpox

0 Actively Recruiting

Dynacin Reviews: What are patients saying about Dynacin?

4.7

Patient Review

1/4/2010

Dynacin for Skin Infection

I had a bad case of Rosacea and this was the medication that helped me. I started seeing results immediately, which was great; however, the side effects were pretty tough to deal with. The constant nausea and dizziness made it hard to function at times. Thankfully, after four months of treatment, the Rosacea was gone for good.

4.3

Patient Review

9/6/2008

Dynacin for Acne

This is a great product and it works well. I would definitely recommend it to others.

4

Patient Review

1/18/2010

Dynacin for Acne

I unfortunately developed a debilitating yeast infection while taking this medication

3.7

Patient Review

9/24/2009

Dynacin for Bacterial Infection due to Deer Fly, Flea & Tick Bites

I have degenerated disc disease and Lyme Disease, both of which cause me a great deal of pain.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dynacin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug minocycline used for?

"Minocycline capsules are used to treat a variety of bacterial infections. They are also used to treat anthrax infection and other infections in patients who cannot receive penicillins. Minocycline belongs to a class of antibiotics called tetracyclines."

Answered by AI

What is dynacin used to treat?

"DYNACIN is an antibiotic medication that belongs to the tetracycline class. It is used to treat infections caused by bacteria, including skin infections, respiratory infections, urinary tract infections, some sexually transmitted diseases, and others. In severe cases of acne, DYNACIN may be used in combination with other treatments."

Answered by AI

What is Minocin 100mg used for?

"Minocin is an antibiotic that is used to treat many different bacterial infections. It is available in generic form."

Answered by AI

What infections is minocycline used for?

"Minocycline is an antibiotic used to treat various types of infections caused by bacteria. These infections include pneumonia, other respiratory tract infections, certain types of skin infections, eye infections, certain infections of the lymphatic system, intestinal infections, genital infections, and urinary infections. Additionally, minocycline can be used to treat certain infections that are spread by ticks, lice, mites, and infected animals."

Answered by AI

Clinical Trials for Dynacin

Image of Seattle Children's Hospital in Seattle, United States.

Follow-Up Strategies for Children With Medical Complexity

1 - 16
All Sexes
Seattle, WA

Children with medical complexity often receive a recommendation to see an outpatient clinician soon after leaving the hospital. It is uncertain whether every child needs this routine visit or whether follow-up can be guided by the family's concerns and the child's recovery. AFTERCARE is a multicenter pilot randomized trial comparing these two follow-up recommendations for children hospitalized with an acute infection. Families will be assigned by chance to receive either a recommendation to arrange follow-up with their usual outpatient clinician within seven days or a recommendation to seek follow-up if the child is not improving as expected or new concerns arise. Families in both groups may seek medical care whenever needed. The study will assess recruitment, follow-up data collection, delivery of the recommendations and acceptability. Caregiver surveys and medical record review will also describe outpatient visits and hospital returns. This pilot will inform the design of a larger trial, and is not designed to establish that the strategies are equally safe or effective.

Waitlist Available
Has No Placebo

Seattle Children's Hospital

Nassr Nama, MD, MSc

Image of University of Texas Health Science Center at San Antonio (Dental School) in San Antonio, United States.

Dexamethasone for Postoperative Pain

18+
All Sexes
San Antonio, TX

Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation. The researchers want to learn if taking dexamethasone by mouth works similarly to receiving dexamethasone through the participant's vein (intravenous, or IV) in reducing short-term pain, swelling, and pain medication after periodontal (gum) flap surgery. The periodontal evaluation, treatment planning, IV sedation, gum surgery, sutures, and usual postoperative care are part of standard care and would be done even if a participant does not join the study. After joining the study, participants will be randomly assigned to the order in which they receive dexamethasone. At one surgery, participants will receive IV dexamethasone plus oral placebo (an inactive substance that looks the same but does not contain dexamethasone). At the next surgery, participants will receive oral dexamethasone plus IV placebo. As part of the study, participants will be asked to record your pain, swelling and any other medication use.

Phase 1 & 2
Waitlist Available

University of Texas Health Science Center at San Antonio (Dental School)

Mostafa Shehabeldin, DDS, MS, PhD

Image of Kaye Edmonton Clinic - University of Alberta School of Dentistry in Edmonton, Canada.

Professional Dental Plaque Disruption for Tooth Decay

5 - 5
All Sexes
Edmonton, Canada

This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment. Families with children aged 5-12 years will be recruited from university dental clinics. Participants will be assigned to one of three treatment groups: treatment for the child only, treatment for the child and parents, or treatment for all family members. Researchers will collect oral bacterial samples from family members before and after treatment and will monitor close-contact interactions within the household using wearable proximity-tracking devices. The study will also collect information about oral health habits, family interactions, and environmental factors that may influence bacterial transmission. By combining bacterial DNA analysis with information about family contact patterns, researchers hope to better understand how oral bacteria are shared within households and whether family-based treatment approaches can reduce bacterial recolonization after dental therapy. The results of this study may help improve strategies for preventing childhood tooth decay and gum disease by addressing family-level sources of bacterial transmission.

Waitlist Available
Has No Placebo

Kaye Edmonton Clinic - University of Alberta School of Dentistry

Have you considered Dynacin clinical trials?

We made a collection of clinical trials featuring Dynacin, we think they might fit your search criteria.
Go to Trials