Dexchlorpheniramine Maleate

Catarrh, Angioedema, Hives + 4 more

Treatment

11 FDA approvals

5 Active Studies for Dexchlorpheniramine Maleate

What is Dexchlorpheniramine Maleate

Dexchlorpheniramine maleate

The Generic name of this drug

Treatment Summary

Dexchlorpheniramine is an antihistamine medication used to treat allergic reactions. It is more powerful than regular chlorpheniramine, since it contains only the active form of the drug.

Dexchlorpheniramine Maleate

is the brand name

image of different drug pills on a surface

Dexchlorpheniramine Maleate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Dexchlorpheniramine Maleate

Dexchlorpheniramine maleate

1984

4

Approved as Treatment by the FDA

Dexchlorpheniramine maleate, also known as Dexchlorpheniramine Maleate, is approved by the FDA for 11 uses which include Allergic Rhinitis (AR) and Vasomotor Rhinitis .

Allergic Rhinitis (AR)

Helps manage Allergic Rhinitis (AR)

Vasomotor Rhinitis

Helps manage Vasomotor Rhinitis

Angioedema

Helps manage Angioedema

Urticaria

Helps manage Urticaria

Catarrh

Rhinitis, Vasomotor

Helps manage Vasomotor Rhinitis

Hypersensitivity

Hives

Helps manage Urticaria

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Angioedema

Helps manage Angioedema

Dermographism

Helps manage Dermographism

Effectiveness

How Dexchlorpheniramine Maleate Affects Patients

Allergic reactions occur when an allergen (a substance that causes an allergic reaction) binds to IgE antibodies on mast cells and basophils. This causes the release of histamine, a chemical which can cause a range of symptoms like itching, redness, low blood pressure, headaches, and difficulty breathing. Dexchlorpheniramine is a medicine that helps block histamine from binding to cells and relieves symptoms of allergies such as hay fever, sneezing, itchy eyes, and a runny nose.

How Dexchlorpheniramine Maleate works in the body

Dexchlorpheniramine works by blocking the histamine receptors on cells responsible for digestion, blood flow and breathing. This drug is more effective than other forms of chlorpheniramine, as it is twice as active.

When to interrupt dosage

The suggested measure of Dexchlorpheniramine Maleate is contingent upon the determined state, such as Allergic Conjunctivitis (AC), Angioedema and Hay Fever. The quantity of dosage fluctuates, depending on the application technique specified in the table below.

Condition

Dosage

Administration

Catarrh

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Syrup

Angioedema

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Syrup

Hives

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Syrup

Dermographism

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Syrup

Rhinitis, Vasomotor

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Syrup

Hypersensitivity

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Syrup

Allergic Conjunctivitis (AC)

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Syrup

Warnings

There are 20 known major drug interactions with Dexchlorpheniramine Maleate.

Common Dexchlorpheniramine Maleate Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Dexchlorpheniramine maleate.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Dexchlorpheniramine maleate.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Artemether.

Dexchlorpheniramine Maleate Toxicity & Overdose Risk

Slowed or depressed brain activity.

image of a doctor in a lab doing drug, clinical research

Dexchlorpheniramine Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Dexchlorpheniramine Maleate?

150 active clinical trials are currently assessing the potential of Dexchlorpheniramine Maleate to provide relief from Allergy, Dermographism and Catarrhal Symptoms.

Condition

Clinical Trials

Trial Phases

Angioedema

1 Actively Recruiting

Phase 4

Hives

0 Actively Recruiting

Hypersensitivity

1 Actively Recruiting

Phase 4

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 3

Catarrh

1 Actively Recruiting

Not Applicable

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Dermographism

0 Actively Recruiting

Dexchlorpheniramine Maleate Reviews: What are patients saying about Dexchlorpheniramine Maleate?

4.7

Patient Review

3/11/2014

Dexchlorpheniramine Maleate for Itching

I was struggling with a skin issue that was only getting worse with my previous doctor's treatment. I decided to switch, and the new doctor put me on Atminic. It worked like a charm--I saw results within just three days! Plus, I didn't experience any negative side effects, which was great.

4.3

Patient Review

11/2/2014

Dexchlorpheniramine Maleate for Added Medication for Life Threatening Allergic Reaction

This medication was incredibly effective for me in addressing a chronic cough that I had been struggling with for some time. Nothing else on the market worked as well as this did to finally give me some relief and allow me to get a good night's sleep.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dexchlorpheniramine maleate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is dexchlorpheniramine maleate?

"Dexchlorpheniramine works by blocking histamine H1 receptors. Histamine is a chemical that is released by the body during an allergic reaction. When histamine binds to histamine H1 receptors, it causes symptoms such as sneezing, itching, and increased mucus production. By blocking histamine H1 receptors, dexchlorpheniramine reduces these symptoms."

Answered by AI

Is dexchlorpheniramine maleate a steroid?

"TheBetamethasone/dexchlorpheniramine drug contains both betamethasone (a steroid) and dexchlorpheniramine maleate (an antihistamine) to treat allergic conditions. The betamethasone component works to relieve itches and inflammation while the dexchlorpheniramine maleate component helps to treat urticaria (hives)."

Answered by AI

What is dexchlorpheniramine maleate used for?

"The medication dexchlorpheniramine is used to relieve symptoms that are commonly associated with allergies, hay fever, and the cold. These symptoms can manifest as a rash, watery eyes, itchiness in the eyes, nose, throat, or skin, a cough, a runny nose, or sneezing."

Answered by AI

Does dexchlorpheniramine make you sleepy?

"While taking dexchlorpheniramine, be cautious about using alcohol as it may increase drowsiness and dizziness. If you experience these effects, avoid activities that require alertness such as operating machinery or driving."

Answered by AI

Clinical Trials for Dexchlorpheniramine Maleate

Image of UPMC Children's Community Pediatrics in Pittsburgh, United States.

Enhanced Telemedicine for Acute Respiratory Tract Infections

6 months - 24 months
All Sexes
Pittsburgh, PA

Young children often receive antibiotics for pediatric acute respiratory tract infections (ARTIs) - common childhood diagnoses like ear infections, strep throat, sinusitis, and colds - but many of these antibiotics are prescribed unnecessarily for viral infections, where antibiotics will not help. Helping families and pediatricians to evaluate children with ARTIs through primary care telemedicine visits using at-home tele-otoscopes vs. at-home eBooks could help reduce unnecessary antibiotic exposure in children. In this clinical trial, we will assess the impact of at-home tele-otoscope vs. eBook enabled primary care telemedicine on antibiotic use, healthcare utilization, and healthcare costs for young children.

Waitlist Available
New This Month

UPMC Children's Community Pediatrics (+1 Sites)

Kristin Ray, MD, MS

Image of Andover Eye Associates in Andover, United States.

Fel d 1 Monoclonal Antibodies for Allergic Eye

Any Age
All Sexes
Andover, MA

This study is researching two experimental medicines, freneslerbart and mevonlerbart. Freneslerbart and mevonlerbart can be given alone or together. When given together, the medicine is called "REGN-2Cat". These medicines are also known as the "study drugs". The aim of the study is to see what side effects freneslerbart, mevonlerbart, and REGN-2Cat may have and if they help reduce eye allergy symptoms caused by cat hair/dander compared with a placebo. The study is looking at several other research questions, including: * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects) * How long the study drug effect lasts

Phase 3
Recruiting

Andover Eye Associates

Clinical Trial Management

Regeneron Pharmaceuticals

Image of Cedars-Sinai Medical Center Otolaryngology Clinics in Los Angeles, United States.

Lavender Aromatherapy for Anxiety and Pain During Otolaryngologic Procedures

18+
All Sexes
Los Angeles, CA

The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting. The main questions it aims to answer are: * Does lavender aromatherapy help reduce anxiety and/or pain, and improve patient comfort during awake otolaryngologic procedures in the clinic? * Do patients subjectively find aromatherapy relaxing and/or beneficial during the procedure? Researchers will compare lavender aromatherapy to placebo (an odorless liquid) to see if lavender aromatherapy helps improve patient comfort during their awake procedure Participants will: * Have their scheduled procedure performed with lavender aromatherapy or placebo during the duration of the procedure * Take a short, less than 1 minute questionnaire both before and after the procedure, describing their levels of anxiety, pain and subjective impressions of the aromatherapy

Recruiting
Paid Trial

Cedars-Sinai Medical Center Otolaryngology Clinics

Ankona Ghosh, MD

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