Cartia Xt

Angina Pectoris, Variant, Atrial Fibrillation, Proteinuria + 11 more

Treatment

6 FDA approvals

20 Active Studies for Cartia Xt

What is Cartia Xt

Diltiazem

The Generic name of this drug

Treatment Summary

Diltiazem is a medication used to lower blood pressure and treat various cardiovascular conditions. It was approved by the FDA in 1982 and is part of a class of drugs known as calcium channel blockers. Diltiazem works by reducing the amount of calcium that enters the heart and blood vessels, which leads to relaxed muscles and lower blood pressure. It is commonly used to treat hypertension, angina, atrial fibrillation and atrial flutter. Diltiazem can also be used for off-label indications such as anal fissures, migraine prevention, pulmonary hypertension, and leg cramps. It is available in extended-

Cardizem

is the brand name

image of different drug pills on a surface

Cartia Xt Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cardizem

Diltiazem

1982

656

Approved as Treatment by the FDA

Diltiazem, commonly known as Cardizem, is approved by the FDA for 6 uses which include Coronary Vasospasm and Coronary Artery Vasospasm .

Coronary Vasospasm

Helps manage Coronary Artery Vasospasm

Coronary Artery Vasospasm

Helps manage Coronary Artery Vasospasm

Anginal Pain

Helps manage Anginal Pain

Hypertensive disease

Helps manage High Blood Pressure (Hypertension)

Angina, Stable

Helps manage Chronic Stable Angina Pectoris

Angina Pectoris

Helps manage Anginal Pain

Effectiveness

How Cartia Xt Affects Patients

Diltiazem is a drug used to lower blood pressure and widen blood vessels. This helps lower the risk of stroke and heart attack. It works by blocking calcium absorption in the muscles of the heart and blood vessels. When taken, it causes the heart rate to slow down and the blood pressure to drop. People with high blood pressure will see the most benefit from taking diltiazem, with a decrease in diastolic blood pressure of up to 8.6 mmHg. It can also improve exercise tolerance in those with chronic stable angina. Studies have shown that diltiazem may help protect against stroke in people with

How Cartia Xt works in the body

Diltiazem works by blocking the slow calcium channels in the heart muscle. This reduces the amount of calcium entering the cells, which relaxes the heart muscle, lowers blood pressure and increases oxygen delivery to the heart. By preventing calcium from entering heart cells, diltiazem also reduces the contractile activity of the heart, resulting in a decrease in heart rate, blood pressure, and cardiac contractility. This helps to improve exercise tolerance in people with chronic stable angina.

When to interrupt dosage

The advised dosage of Cartia Xt is reliant upon the diagnosed affliction, for example prophylaxis of migraine headaches, Fissure;Anal and Anginal Pain. The amount of dosage fluctuates as per the mode of administration indicated in the table below.

Condition

Dosage

Administration

Atrial Fibrillation

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Coronary Vasospasm

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Hypertensive disease

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Angina Pectoris

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Angina Pectoris, Variant

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Proteinuria

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Angina, Stable

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Tachycardia, Supraventricular

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Cardiomyopathy, Dilated

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Migraine Disorders

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Diabetic Neuropathy

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Pulmonary Hypertension

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Fissure in Ano

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Muscle Cramp

, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL

, Tablet, extended release, Oral, Tablet, extended release - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Powder, for solution - Intravenous, Capsule - Oral, Capsule, Tablet - Oral, Tablet, Tablet, coated, Tablet, coated - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Injection, powder, lyophilized, for solution, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution - Intravenous

Warnings

Cartia Xt has ten contraindications and should not be employed in combination with any of the conditions indicated in the following table.

Cartia Xt Contraindications

Condition

Risk Level

Notes

Heart Attack

Do Not Combine

accessory bypass tract

Do Not Combine

accessory bypass tract

Do Not Combine

Bradycardia

Do Not Combine

Ventricular Tachycardia

Do Not Combine

Bradycardia

Do Not Combine

Atrioventricular Block

Do Not Combine

Pulmonary Congestion

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Hypotension

Do Not Combine

There are 20 known major drug interactions with Cartia Xt.

Common Cartia Xt Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Diltiazem.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Diltiazem.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Diltiazem.

Alfentanil

Major

The metabolism of Alfentanil can be decreased when combined with Diltiazem.

Amifostine

Major

Diltiazem may increase the hypotensive activities of Amifostine.

Cartia Xt Toxicity & Overdose Risk

The toxic dose of diltiazem in mice is between 415-740mg/kg and 560-810mg/kg in rats. The toxic dose in dogs is greater than 50mg/kg and in monkeys, a dose of 360mg/kg was lethal. People who overdose on diltiazem may experience a slow heartbeat, low blood pressure, heart blockage, or heart failure, which can cause dizziness, lightheadedness, and fatigue. Treatment may involve administering atropine, fluids, and vasopressors. Gastric lavage, activated charcoal, and intravenous calcium may also be used. Long-

image of a doctor in a lab doing drug, clinical research

Cartia Xt Novel Uses: Which Conditions Have a Clinical Trial Featuring Cartia Xt?

Currently, 228 active clinical trials are assessing the effectiveness of Cartia Xt in managing Atrial Fibrillation, Coronary Artery Spasm and Paroxysmal Supraventricular Tachycardia (PSVT).

Condition

Clinical Trials

Trial Phases

Atrial Fibrillation

103 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 3, Phase 2, Early Phase 1

Diabetic Neuropathy

6 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Pulmonary Hypertension

36 Actively Recruiting

Phase 2, Phase 3, Phase 1, Not Applicable, Early Phase 1

Tachycardia, Supraventricular

1 Actively Recruiting

Phase 2

Angina, Stable

0 Actively Recruiting

Angina Pectoris, Variant

0 Actively Recruiting

Angina Pectoris

2 Actively Recruiting

Not Applicable, Phase 4

Cardiomyopathy, Dilated

0 Actively Recruiting

Proteinuria

6 Actively Recruiting

Phase 2, Phase 3, Phase 4, Phase 1, Not Applicable

Muscle Cramp

0 Actively Recruiting

Hypertensive disease

41 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2

Coronary Vasospasm

0 Actively Recruiting

Migraine Disorders

1 Actively Recruiting

Phase 3

Fissure in Ano

0 Actively Recruiting

Cartia Xt Reviews: What are patients saying about Cartia Xt?

5

Patient Review

5/18/2021

Cartia Xt for Rapid Ventricular Heartbeat

I've been on this medication for over a decade and it has completely controlled my irregular heartbeat. I'm so thankful that I found this before having to resort to surgery. There are a few generics out there, but the white/orange pill is the best one for me.

5

Patient Review

5/5/2014

Cartia Xt for Angina

5

Patient Review

10/24/2017

Cartia Xt for Angina

I had angina when jogging, but after being diagnosed with endothelial dysfunction and put on Cartia XT, I was able to jog with no problem the very next day! No side effects either, which is great.

4.3

Patient Review

6/14/2016

Cartia Xt for High Blood Pressure

My cardiologist recommended this to help with my extreme hand pain during winter from the cold. Not only does it take care of my high blood pressure, but also my high heart rate.

4.3

Patient Review

5/30/2016

Cartia Xt for Ventricular Rate Control in Atrial Fibrillation

I've been noticing that I'm losing more hair than usual. Has anyone else experienced this side effect?

4

Patient Review

4/13/2016

Cartia Xt for High Blood Pressure

My blood pressure was lowered by this medication, however I experienced bad swelling of my ankles and hands. Additionally, it caused nightmares. The swelling became too much so I had to switch to a new drug.

4

Patient Review

6/2/2019

Cartia Xt for High Blood Pressure

I was a little worried about the drowsiness at first, but it's gone away as I've continued taking the medication. There's also a brief period of high-pitched ringing in my ears, but that dissipates quickly too. On the plus side, my blood sugar and blood pressure have both improved.

4

Patient Review

7/23/2014

Cartia Xt for Ventricular Rate Control in Atrial Fibrillation

Unfortunately, I didn't see any change in my blood pressure after a month of taking this medication. My readings were 140/80 before and they remained the same while on the drug.

3.7

Patient Review

9/23/2015

Cartia Xt for High Blood Pressure

My blood pressure has normalized since taking this medication, but I've been experiencing weird heart palpitations and chest tightness. The dry mouth and headaches are also pretty unpleasant side effects.

3

Patient Review

8/22/2020

Cartia Xt for High Blood Pressure

I am taking 120 mg daily along with Olemarsartan 40 mg. The blood pressure seems to have gone down some but I am very lethargic and don't have the enery I had before started taking this medicine. My hair also has thinned out all of a sudden.

3

Patient Review

5/9/2016

Cartia Xt for Ventricular Rate Control in Atrial Fibrillation

I've been on this medication for just under a month, and it seems to be helping. The biggest issue I have is fatigue, but that could improve with time.

2.7

Patient Review

12/14/2015

Cartia Xt for High Blood Pressure

I'm not sure if this is working as intended. I've been on it for eight days now with no change in heart rate.

2.3

Patient Review

9/24/2015

Cartia Xt for High Blood Pressure

I experienced some very unpleasant side effects while taking this medication, including cold chills around my torso. Once I stopped taking the medication, those symptoms resolved within a few days.

2.3

Patient Review

4/9/2016

Cartia Xt for High Blood Pressure

I was prescribed this to help with my enlarged heart. I only took one pill and it made me feel incredibly weak, depressed, and almost unable to function. Needless to say, I didn't take the second pill.

2

Patient Review

6/4/2014

Cartia Xt for High Blood Pressure

This medication is working well for my SVT.

1.7

Patient Review

6/16/2017

Cartia Xt for High Blood Pressure

I was prescribed this medication for high blood pressure, but I stopped taking it after eight months because of the negative side effects I experienced. These included palpitations, fatigue, nightmares, and a rash.

1.3

Patient Review

2/7/2017

Cartia Xt for Ventricular Rate Control in Atrial Fibrillation

Unfortunately, I had an allergic reaction to this medication.

1

Patient Review

12/15/2018

Cartia Xt for High Blood Pressure

This drug is terrible. I've only been taking it for a couple weeks and I'm already done with it. It's given me headaches, dry mouth, ringing in my ears, rage, dizziness, and lightheadedness. There's also a spot on my foot that I have no idea what it is. If you're considering this treatment, please reconsider.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cartia xt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When is the best time to take Cartia XT?

"The suggested dose for adults is 30 mg, four times a day, before meals and at bedtime. The doctor may change the amount as necessary. The dose for children depends on what the doctor prescribes."

Answered by AI

What are the side effects of Cartia XT?

"The following effects may occur: dizziness, lightheadedness, weakness, nausea, flushing, constipation, and headache. If you experience any of these effects, talk to your doctor or pharmacist. To reduce the risk of dizziness and lightheadedness, stand up slowly when you get up from a sitting or lying position."

Answered by AI

Is Cartia XT the same as diltiazem?

"Cartia XT (diltiazem hydrochloride) is a drug used to treat hypertension, angina and certain heart rhythm disorders. It is available in generic form."

Answered by AI

When is the best time to take Cartia?

"-The recommended dose is one Cartia 100 mg low dose aspirin tablet taken at the same time every day. -Take Cartia with a glass of water. Cartia should be swallowed whole, without crushing, chewing or breaking the tablet. -Cartia can be taken with or without food."

Answered by AI

Clinical Trials for Cartia Xt

Image of Caridad Center, Inc. in Boynton Beach, United States.

CHW Nutrition Support for Type 2 Diabetes

18+
All Sexes
Boynton Beach, FL

This study tests whether adding CHW support to usual nutrition care helps adults with type 2 diabetes, hypertension, or chronic kidney disease manage their diet and health. At Caridad Center, a free clinic in Palm Beach County, Florida, usual care includes medical nutrition therapy from a registered dietitian and medically tailored groceries. Many patients find it hard to keep up dietary changes because of limited nutrition knowledge, cooking skills, food costs, and cultural fit. Two hundred adults will be randomly assigned to usual care or usual care plus INTEGRATE-CHW, a 12-week program of six sessions with a trained CHW. In each session the participant selects one or two goals from the dietitian's plan and builds an action plan with the CHW. The dietitian remains responsible for the nutrition plan. The study will compare nutrition self-efficacy, nutrition literacy, diet quality, food security, and clinical measures between groups at baseline and Week 12. It will also evaluate how well the program fits into routine clinic care.

Waitlist Available
Has No Placebo

Caridad Center, Inc.

Janet Diaz Martinez

Image of Satellite Healthcare - Daly City in San Francisco, United States.

Blood Pressure Management for Kidney Failure

18+
All Sexes
San Francisco, CA

The GOAL-BP pilot study will help determine whether a study comparing two blood pressure goals can be carried out in adults with end-stage kidney disease and high blood pressure who receive peritoneal dialysis. The main questions it aims to answer are whether eligible patients can be recruited for the study. Researchers will compare two goals for the top blood pressure number (systolic blood pressure): below 120 mmHg versus below 140 mmHg.This pilot study will help plan a larger trial in the future. Participants will: * Be assigned by chance to one of the two blood pressure goals. * Have their blood pressure measured at clinic visits about every two weeks. * Work with their kidney doctor on recommended changes to fluid management, peritoneal dialysis treatment, or blood pressure medicines to reach their assigned goal. * Be part of the study for about four and a half months.

Recruiting
Has No Placebo

Satellite Healthcare - Daly City (+2 Sites)

Chi-yuan Hsu, MD, MS

Image of Huntsman Cancer Institute, University of Utah in Salt Lake City, United States.

Belzutifan for Polycythemia

18+
All Sexes
Salt Lake City, UT

Some people develop erythrocytosis, a condition characterized by having too many red blood cells, because of inherited changes (mutations) in genes such as EPAS1, EGLN1, or VHL. These genes are involved in the body's oxygen-sensing pathway and can cause the body to produce excess red blood cells. High red blood cell counts can increase the risk of symptoms and complications, including headaches, blood clots, and cardiovascular problems. This study will evaluate whether belzutifan, a medication that blocks the activity of HIF-2α, can reduce red blood cell production and improve blood counts in patients with erythrocytosis caused by these genetic mutations. Participants will receive belzutifan and undergo regular clinical assessments and laboratory testing to monitor treatment response and safety. The results of this study may provide a new targeted treatment option for patients with hereditary erythrocytosis caused by abnormalities in the oxygen-sensing pathway.

Phase 2
Waitlist Available

Huntsman Cancer Institute, University of Utah

Josef T. Prchal, MD

Image of Allegheny General Hospital in Pittsburgh, United States.

Bachmann's Bundle vs Right Atrial Appendage Pacing for Atrial Fibrillation

18+
All Sexes
Pittsburgh, PA

Participants will be randomly assigned to one of two clinical treatment Arms, both of which are standard care procedures performed in the right atrium (RA): Arm A: Pacing from the Bachmann's Bundle (BB) in the right atrium (upper right chamber of the heart) Arm B: Pacing from the right atrial appendage (RAA - a sac attached to the right atrium) Neither of these treatments are experimental; both are routinely performed by Electrophysiologists in the clinical setting. The purpose of this study is to compare side by side these two treatments and evaluate if one is better than the other. After the procedure, participants will be followed for one year. Medical record data will be collected, and a blood sample will be collected upon enrollment and at one year after implantation. Research-related surveys will be completed at the standard-care 3-, 6-, and 12-month visits.

Recruiting
Has No Placebo

Allegheny General Hospital

Joshua Silverstein, MD

Medtronic

Have you considered Cartia Xt clinical trials?

We made a collection of clinical trials featuring Cartia Xt, we think they might fit your search criteria.
Go to Trials
Image of Foothills Medical Center in Calgary, Canada.

Spinal Cord Stimulation for High Blood Pressure

18+
All Sexes
Calgary, Canada

High blood pressure, also called hypertension, raises the risk of heart disease, stroke, and kidney disease. Medications work well for many people, but some people still have blood pressure that stays too high, or they have side effects from their medications. Researchers are looking for treatments that do not involve taking more medication. Nerves help control blood pressure by changing how blood vessels tighten and how hard the heart pumps. Because of this, treatments that act on nerves may be able to lower blood pressure. Spinal cord stimulation is a treatment already used to manage long-term pain. It uses a small device, placed under the skin during a standard operation, that sends mild electrical signals to the spine. Laboratory studies suggest that stimulating the lower part of the mid-back may also lower blood pressure, but this has not been carefully studied in people who already use these devices. This study will look at whether changing the settings on a spinal cord stimulator affects blood pressure. About 11 adults who have high blood pressure and who already have a spinal cord stimulator for long-term pain. No new device will be placed, and no surgery or other invasive procedure will be done for this study. Participants attend a series of study visits. At each visit, trained staff record blood pressure and heart rate while the stimulator is turned on, turned off, and set to other settings that the person's care team has approved and that the person finds comfortable. There are rest breaks between each setting. Over successive visits, the study team works to identify the settings that best lower blood pressure. Participants can stop at any time, and their usual settings are restored at the end of each visit. The study will also look at whether this kind of testing is practical and comfortable for participants. The results will help researchers decide whether larger studies of spinal cord stimulation for blood pressure control are worth doing.

Waitlist Available
Has No Placebo

Foothills Medical Center

Aaron Phillips, PhD

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Image of Science and Engineering Innovation and Research Building (SEIR), University of Texas at Arlington in Arlington, United States.

Alcohol Abstinence for High Blood Pressure

26 - 49
All Sexes
Arlington, TX

The purpose of this study is to learn whether avoiding alcohol can improve heart and blood vessel health in adults who regularly drink alcohol and have high blood pressure. High blood pressure is a major risk factor for cardiovascular disease (CVD), including heart attack and stroke. In this randomized, controlled trial, men and women aged 26 to 49 years who regularly consume alcohol and have high blood pressure will be assigned by chance to either stop drinking alcohol or continue their usual drinking habits for 8 weeks. Researchers will compare changes in blood pressure and other cardiovascular disease risk factors between the two groups. The information gained from this study may help researchers and health care providers better understand the effects of alcohol consumption on cardiovascular health and whether alcohol abstinence can reduce heart disease risk, especially in adults with high blood pressure.

Recruiting
Has No Placebo

Science and Engineering Innovation and Research Building (SEIR), University of Texas at Arlington

Image of Department of Family & Community Medicine; University of Alabama at Birmingham in Birmingham, United States.

Treatment for High Blood Pressure

18+
All Sexes
Birmingham, AL

The researchers will invite 30 patients in primary care who have high blood pressure to participate in this health program with a supportive partner of their choosing (these will be the "participant pairs"). Participant pairs will be invited to complete the Heart Care Pairs health program that will include up to six sessions each including 1) some education on a health habit like physical activity and heart healthy foods, 2) goal setting together, and 3) talk about healthy communication to support one another with heart healthy habits. The researchers will work with participants to address things that get in the way of coming for visits like offering transportation and offering telehealth visits. The researchers are seeing how this program works in real life so participants will be asked to complete as many sessions as they want to and can attend. The researchers will be interested in what participants think about the sessions, if they were satisfied with the visits, and if they would recommend the program to others in their community. The researchers will ask these questions in interviews with participants. The researchers will also ask up to 25 primary care workers about how they view the program as helpful to their work with patients with high blood pressure and whether they would refer more patients to the program in the future.

Waitlist Available
Has No Placebo

Department of Family & Community Medicine; University of Alabama at Birmingham

Image of London Health Sciences Centre (LHSC) in London, Canada.

BASIC-S Intervention for Cardiovascular Risk

18+
All Sexes
London, Canada

Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging. To address this, we developed BASIC-S (Blood Pressure, Activity, Sleep, Interaction, Consumption, and Support), a framework targeting Blood pressure, Activity, Sleep, Interaction (socially), Consumption (nutrition), and Support using partner support and motivational interviewing. This individual-focused approach bypasses the logistical and financial barriers of complex clinical interventions by using sustained behavioral science to support gradual lifestyle changes. This study is a single-center, mixed-methods, cluster-randomized pilot trial evaluating the feasibility of the BASIC-S protocol in an occupational setting. A maximum of 60 households (120 participants) will be randomized 1:1 to either the BASIC-S intervention (motivational coaching, secure video check-ins, automated text messages, and a digital workbook) or standard care. Outcomes will assess feasibility, acceptability, and the validity of new tracking metrics to inform a future full-scale trial.

Waitlist Available
Has No Placebo

London Health Sciences Centre (LHSC)

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