Supplement Combination for Healthy Subjects

This trial aims to evaluate how a combination of supplements affects sleep quality and stress levels in healthy adults. Participants will test different supplement combinations in the morning (AM Active Supplement Combination) and evening (PM Active Supplement Combination) to identify the most effective one. Ideal candidates are healthy individuals who exercise regularly and have not recently changed their supplement routine. Participants must own an Apple device with the latest iOS software.

As an unphased trial, this study provides a unique opportunity to explore personalized supplement combinations for improved well-being.

The trial does not specify if you need to stop taking your current medications, but if you are taking medication to manage sleep or cortisol levels, you cannot participate. If you started a new supplement in the past month, you'll need to stop it and wait for 2 weeks before joining the study.

Research has shown that the safety of the AM Active Supplement Combination, which includes Ashwagandha and Rhodiola rosea, has been studied in various settings. These ingredients are common in dietary supplements and are usually well-tolerated. However, some studies, such as those involving military personnel, have reported unexpected negative effects with similar products.

For the PM Active Supplement Combination, specific safety information remains limited. While dietary supplements are generally considered safe, less is known about their long-term effects. Participants should also be aware of potential interactions with other medications or supplements.

Researchers are excited about these supplement combinations because they offer a fresh approach to enhancing overall health in healthy individuals. Unlike traditional supplements that may target single nutrients, these combinations feature a blend of active ingredients tailored for morning or evening use, potentially optimizing the body's natural rhythms. This tailored approach could lead to more effective nutrient absorption and better support for the body's daily functions, setting this trial apart from existing one-size-fits-all supplements. Additionally, the use of both active and placebo comparisons helps to thoroughly assess the true impact of these combinations, providing clearer insights into their potential benefits.

This trial will evaluate different supplement combinations for their effects on sleep and stress in healthy subjects. Participants will join one of several treatment arms, which include combinations of active supplements and placebos. Studies have shown that some supplements can improve sleep quality and reduce stress. For example, one study found that a mix of S-adenosyl methionine (SAMe) and probiotics improved mood, potentially aiding stress relief. Another study showed that a supplement with multiple nutrients reduced inflammation, which can indirectly enhance sleep and stress levels. While research on these specific combinations continues, the potential benefits are based on how these ingredients function in the body. Scientists are exploring how these supplements might aid sleep and stress, and early results are promising.¹²⁶⁷⁸