42 Participants Needed

Physical Rehabilitation for Ankle Injury

AB
Overseen ByAdam B Rosen, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to improve treatments for individuals with chronic ankle instability (CAI), a condition where the ankle often feels unstable and can easily give way. Researchers seek to understand the different types of CAI and their effects on balance and brain function. Participants will engage in a 4-week balance training program, a form of physical rehabilitation, to determine its impact on stability and performance. Ideal candidates for this trial are physically active, have a history of ankle sprains, and experience frequent ankle instability. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to better treatments for CAI.

Will I have to stop taking my current medications?

The trial excludes participants who are currently taking medications that may affect cognitive function, such as narcotics, anti-depressants, anti-anxiety agents, or stimulants. If you are taking any of these, you may need to stop them to participate.

What prior data suggests that this rehabilitation protocol is safe for ankle injury recovery?

Research shows that balance training is generally safe and well-tolerated. Studies have found that athletes who perform balance exercises experience fewer ankle sprains. One study found that balance training lowered the risk of ankle injuries by 46%. Another study showed a 36% drop in ankle injury rates when balance exercises were included in injury prevention programs.

Balance training not only helps prevent injuries but also improves ankle function. Participants reported feeling more stable in their ankles after these exercises. Additionally, engaging in balance training for at least six weeks after an ankle sprain significantly reduced the chance of future sprains.

Overall, balance training exercises are considered safe and effective for improving ankle stability and preventing injuries.12345

Why are researchers excited about this trial?

Researchers are excited about this rehabilitation method because it takes a fresh approach to ankle injury recovery. Unlike traditional treatments that often focus solely on rest or simple exercises, this method emphasizes dynamic balance training. By incorporating exercises like single-limb hops to stabilization and unanticipated hops, it aims to enhance both stability and reaction time. This could lead to faster and more comprehensive recovery, allowing patients to regain full function more effectively.

What evidence suggests that this physical rehabilitation is effective for chronic ankle instability?

Research has shown that balance training, which participants in this trial will receive, helps manage chronic ankle instability (CAI). Studies have found that balance exercises improve ankle mobility and reduce the risk of future ankle sprains. For example, one review found that including balance training in an exercise program reduced the chance of lower limb injuries by 39%. Another study demonstrated that performing balance exercises for at least six weeks after an ankle sprain significantly decreased the risk of another sprain. These findings suggest that balance training is an important part of recovery for those with CAI.25678

Who Is on the Research Team?

AB

Adam B Rosen, PhD

Principal Investigator

University of Nebraska

Are You a Good Fit for This Trial?

This trial is for individuals with chronic ankle instability (CAI) who are looking to improve their condition. The study aims to understand functional and neurophysiological differences in CAI subgroups, which will help tailor more effective rehabilitation programs.

Inclusion Criteria

Coper participants: a history of lateral ankle sprain, but no episodes of giving way in previous 12 months, CAIT score greater than 28
I have a history of ankle sprains and my ankle often gives way.
All participants must be physically active (participation in at least 90 total minutes of activity/week including running, walking, lifting weights, or playing a sport, etc.)
See 1 more

Exclusion Criteria

I have had surgery or a fracture in my leg.
I have a history of conditions like concussion that affected my thinking.
I have been diagnosed with a nerve or connective tissue disorder.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo baseline assessments including side-hop test, choice-reaction hop test, and inversion-eversion force control

1 week
1 visit (in-person)

Treatment

Participants engage in a 4-week neurocognitively enhanced balance training protocol

4 weeks
Weekly visits (in-person)

Post-rehabilitation Assessment

Participants are reassessed using the same tests as baseline to evaluate changes post-rehabilitation

1 week
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Physical Rehabilitation
Trial Overview The study tests the effects of a specialized 4-week balance training program on people with different types of chronic ankle instability. It measures performance on physical tasks and assesses changes in nerve system function and muscle control.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Balance TrainingExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Nebraska

Lead Sponsor

Trials
563
Recruited
1,147,000+

Published Research Related to This Trial

Effective rehabilitation of foot and ankle injuries is crucial for full recovery and preventing chronic issues, involving both physical therapy modalities and rehabilitative exercises.
Rehabilitation strategies, including the use of thermal, mechanical, and electrical agents, aim to reduce pain and swelling while enhancing strength and proprioception, particularly for common injuries like lateral ankle sprains.
Rehabilitation of foot and ankle injuries.Losito, JM., O'Neil, J.[2005]
A systematic review of 21 studies found that training programs are more effective than conservative treatments for improving pain and function in patients with chronic complaints after ankle sprains.
There is limited evidence suggesting that proprioceptive training can reduce the recurrence of ankle sprains, while the effectiveness of surgical treatments remains unclear due to a lack of comparative studies.
Chronic complaints after ankle sprains: a systematic review on effectiveness of treatments.van Ochten, JM., van Middelkoop, M., Meuffels, D., et al.[2022]

Citations

A systematic review and meta-analysis of balance training ...Previous studies [9, 10] have shown that early and standardized rehabilitation after CAI can avoid and improve ankle joint range of motion ...
Effectiveness of exercise therapy on chronic ankle instabilityA systematic review has indicated that balance training has a notable therapeutic effect on CAI; however, it did not evaluate the efficacy of ...
Meta-analysis of the dosage of balance training on ankle ...A review concluded that balance training effectively reduces the risk of ankle sprain in sports participants [10]. Previous studies also showed ...
Injury prevention programs that include balance training ...The pooled result of multi-intervention programs that included balance training showed reductions in lower limb injuries by 39% (RR 0.61, 95% CI 0.49 to 0.77) ...
Systematic Review of Postural Control and Lateral Ankle ...Completing at least 6 weeks of balance training after an acute ankle sprain substantially reduced the risk of recurrent ankle sprains; however, consistent ...
THE EFFECT OF BRACING AND BALANCE TRAINING ON ...Athletes performing balance training had fewer ankle sprains (p=0.0057) and reduced their risk by 46% (RR=0.54) compared to controls, based on analysis of 3,577 ...
Effects of combination of strength and balance training on ...Balance training may help to improve ankle function and reduce incidence rate, and the effect is similar to that of strength training. The ...
Comparing virtual reality and balance training effects on ...The results of this study indicated that both the VR games and balance training groups effectively improved perceived ankle instability and ...
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