66 Participants NeededMy employer runs this trial

Catheter Infusions for Pain Management in Broken Ribs

HM
LK
Overseen ByLilia Kaustov, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Sunnybrook Health Sciences Centre
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Rib fractures happen in about 10-20% of patients with blunt trauma and can be serious, with higher death rates in older adults. These injuries often lead to lung problems like pneumonia, collapsed lung areas (atelectasis), fluid buildup, or even respiratory failure. A major reason for this is pain-patients avoid deep breathing and coughing, which worsens lung function. Good pain control helps prevent these complications.

Opioids are commonly used for pain but can cause problems such as slowed breathing, delirium, nausea, and longer time on a ventilator. Because of this, regional anesthesia (nerve blocks) is increasingly used to control pain while reducing opioid use. Common options include epidurals, paravertebral blocks, and newer techniques like erector spinae plane (ESP) and serratus anterior plane (SAP) blocks. Continuous catheter techniques are especially useful in trauma patients because they can provide ongoing pain relief and have fewer contraindications than epidurals.

The SAP block is done at the side of the chest and works well for rib fractures in the front and side. It may not work as well for fractures in the back, although trauma may sometimes allow the anesthetic to spread further than expected.

The ESP block is done near the spine and may cover a broader area, including both front and back of the chest. It is relatively easy to perform at the bedside and is considered safe. Studies suggest it provides pain relief similar to epidurals in some patients.

There is still limited evidence directly comparing continuous SAP and ESP catheters. Only one study (using single injections) suggests ESP may provide better pain relief. It is unclear whether that difference holds true with continuous infusions, or whether SAP might be preferable because it is easier and quicker to perform.

We propose a randomized trial comparing continuous ESP and SAP catheters in patients with rib fractures to determine which provides better pain control, reduces opioid use, improves breathing outcomes, and is easier to perform in routine practice.

Our hypotheses are that ESP will provide better pain relief, SAP will be easier and safer to place, and both techniques will reduce opioid use while maintaining good patient comfort and breathing.

Are You a Good Fit for This Trial?

This trial is for adults (over 18) hospitalized within 72 hours after having at least 3 rib fractures on one or both sides, who have significant chest pain. People can't join if they have blood clotting problems, are pregnant, have severe brain injury, allergies to anesthetics, certain infections or surgeries planned soon, need a ventilator right away, or use high-dose opioids regularly.

Inclusion Criteria

I am over 18 years old.
I have had broken ribs from an injury.
I have at least three broken ribs on each side of my chest.
See 2 more

Exclusion Criteria

I have a bleeding disorder that is not under control.
Pregnancy
I have had a severe traumatic brain injury.
See 8 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive either erector spinae plane catheter or serratus anterior plane catheter for pain management

72 hours
Continuous monitoring during hospital stay

Follow-up

Participants are monitored for safety, effectiveness, and complications after catheter placement

7 days
Daily assessments during hospital admission

Hospital Stay

Participants remain in the hospital for observation and management of rib fractures and associated complications

Average of 7 days

What Are the Treatments Tested in This Trial?

Interventions

  • Erector Spinae Plane Catheter Infusion
  • Serratus Anterior Plane Catheter Infusion

Trial Overview

The study compares two types of nerve block catheters—erector spinae plane (ESP) and serratus anterior plane (SAP)—to see which provides better ongoing pain relief for patients with traumatic rib fractures. Patients are randomly assigned to receive either ESP or SAP catheter infusions.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Serratus plane catheterExperimental Treatment1 Intervention
Group II: Erector spinae plane catheterActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Sunnybrook Health Sciences Centre

Lead Sponsor

Trials
693
Recruited
1,569,000+